NEW PREPRINT FROM THE LAB IS OUT — DON’T MISS IT! www.biorxiv.org/content/10.6... We asked whether the 3D architecture of the inactive X -  and in particular CTCF and cohesin -  is what keeps escapee genes active. Spoiler: it isn’t.

X-inactivation escapee domains are CTCF-cohesin independent chromatin compartments

X-chromosome inactivation involves chromosome-wide gene silencing accompanied by extensive chromatin changes, as well the loss of topologically associating domains. Yet discrete regions of the inactiv...

biorxiv.org

Have you ever wondered why developmental genes are often regulated by enhancers located at long distances? In this @natgenet.nature.com perspective, we speculate that long-range enhancer positioning may provide regulatory properties essential for proper gene expression www.nature.com/articles/s41...

Mechanisms and functional implications of long-range enhancer-dependent gene regulation - Nature Genetics

Development depends on gene regulation by enhancers across long genomic distances. This Perspective discusses mechanisms enabling long-range enhancer–promoter communication and the potential advantage...

nature.com

Newest from the lab - and the only of our manuscripts since the introduction of bioRxiv that we did not preprint (it will become obvious why). "Targeting addiction to HMGB2-driven transcriptional programs in pancreatic cancer" A thread...

🔬 Metástasis: ¿su punto débil? @alteamanzanolab.bsky.social  @eleconomista.es 

La científica española que busca el punto débil de la metástasis del cáncer: "El gran reto es entender qué hace que estas células tengan superpoderes"

Tener 'superpoderes' no siempre es positivo y tampoco se asocia siempre a héroes que salvan el mundo. Se define como una habilidad o facultad extraordinaria, es decir, fuera de lo común, y es lo que ocurre con las células tumorales capaces de iniciar la metástasis. Patricia Altea (Sevilla, 1988), directora del grupo de Regulación Metabólica y Señalización en Cáncer del Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) quiere descubrir porqué estas unidades concretas tienen dicha cualidad y junto con su equipo en el CABIMER investiga cómo funciona este proceso para cambiar el pronóstico de las pacientes con cáncer de mama. Ella fue la ganadora del premio a la mejor investigadora joven de los Premios Hipatia de elEconomista.es en su última edición.

eleconomista.es

Sign up now for the EMBO meeting 'quantitative biology to molecular mechanisms'. Fantastic speaker lineup and plenty of speakers slots selected from abstracts. Submit your abstract before Sept 11!

EMBL Events@events.embl.org · last mo.

You only have until 11 Sep to submit your abstract for #EMBOomics! ➡️ s.embl.org/omx26-01-bl Join us to discuss the latest developments in the field with leaders in genomics, dynamic proteomics, quantitative imaging, and synthetic biology.

📣 Preprint alert! We developed a method to analyze concurrent interactions between multiple chromatin regions at single alleles at sub-nucleosome resolution (multi-way Micro-Capture-C, mwMCC) & used this to study structural synergy within super-enhancers. 1/14 www.biorxiv.org/content/10.6...

Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation

Developmental Cell@cp-devcell.bsky.social · last mo.

Online now: Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors #biology #science

How many TFs to you need to open chromatin at enhancers? Very excited to see this one out! Check out the augmented version with combinatorial motif mutant libraries in Figure 5! Very proud of @guidobarzaghi.bsky.social @valentinabaderna.bsky.social @embl.org

Guido Barzaghi@guidobarzaghi.bsky.social · last mo.

📄 That's a wrap 📄 we're excited to share that the latest from @arnaudkr.bsky.social 's lab and Judith Zaugg's lab is at last online at doi.org/10.1038/s415.... Many thanks to my co-first @valentinabaderna.bsky.social and to @embl.org for the wonderful research environment.

🚨the latest from the lab! 😃👇🏻 www.science.org/doi/10.1126/...

3D genome organization in tissue regeneration involves long-range chromatin loops

Chromosome conformation analysis in Drosophila wing discs reveals the requirement of specific meta-loops during regeneration.

science.org

Sailing in @biorxivpreprint.bsky.social ready for summer, our study on the iconic Portuguese man o' war 🪼 is out: www.biorxiv.org/content/10.6.... We use (epi)genomics to understand a critter that fascinates me since childhood. Massive team effort with @obog.bsky.social, Cummins and Neely groups. 🧵

🫵🏼 If you want to do a PhD studying this wonderful creature of the pic, WE ARE NOW HIRING 💰!! Go to our profile for more info ℹ️. Postdocs are also welcome to get in touch!! 👇🏼👇🏼👇🏼👇🏼

Genetics UB@geneticsub.bsky.social · 2mo ago

🎨 We merge science and art in our #PicOfTheMonth at @geneticsub.bsky.social 🔬 The image shows a lateral view of the trunk of an adult Oikopleura dioica, the closest living invertebrate relative to humans and other vertebrates. 📸 by @alfonso233.bsky.social @evodevogenomeub.bsky.social

Thank you @natgenet.nature.com for this nice Research Briefing www.nature.com/articles/s41... on our recent paper reporting live-cell measurements of Sox2 promoter bursting kinetics when varying its genomic distance from the SCR enhancer 👉 www.nature.com/articles/s41...

The genomic position of an enhancer modulates bursting dynamics of the cognate promoter - Nature Genetics

We show that, in a genomic locus with minimal complexity, the distance between promoter and enhancer modulates the frequency of clustered transcriptional bursts. Thus, besides the nucleotide sequence,...

nature.com

The third chapter in our coral single-cell trilogy is here. After mapping cell type diversity in Stylophora (Levy 2021) and exploring facultative symbiosis in Oculina (Levy 2025), we now uncover cell type-specific responses to heat stress. Find out more in @xgrau.bsky.social's thread below.

Cell-resolved transcriptional responses during heat-induced coral bleaching and recovery

Coral reefs depend on an intracellular symbiosis between cnidarian hosts and photosynthetic dinoflagellates that is disrupted by ocean warming, causing coral bleaching. Yet how these responses are dis...

biorxiv.org

Xavier Grau-Bové 🌾@xgrau.bsky.social · 2mo ago

I'm happy to share our latest on #coral single-cell biology: a transcriptomic timecourse of heat stress in Stylophora pistillata, from bleaching to recovery 🪸🌊 This project was spearheaded by Shani Levy and carried through in @arnausebe.bsky.social's lab at @crg.eu. www.biorxiv.org/content/10.6...

Our latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells. www.nature.com/articles/s43...

Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program - Nature Aging

Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

nature.com

🚨 Job Alert - Please share 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! ✅ 4 years fully funded PhD position 💻🧪 Experimental or computational backgrounds welcome 👇 Details below #PhDPosition #PhDOpportunity #AcademicJobs

Beautiful

Oisín McGann@oisinmcgann.bsky.social · 2mo ago

I don’t know why this post doesn’t give his name, but it’s Jo Nagai. This is a true story. medium.com/@zehraanjum2...

Our new paper is out in @nature.com! We uncovered how a naked mole-rat queen 👑 controls an entire colony: a natural contraceptive scent that suppresses reproduction in other females! A remarkable mammalian parallel to bees and ants! 🐝🐜 @garyrlewin.bsky.social youtu.be/enfv3zJrWKM?...

Naked mole-rats are ruled by a queen: this chemical puts her in power

YouTube video by nature video

youtu.be

🚨 Early Bird registration and abstract submission deadline for #SEBD2026 extended!! 📅 Early registration and abstract submission deadline: 10th July 📅 Scholarship application deadline: 29th June www.sebd2026.com #SEBD #DevBio @sebioldev.bsky.social 👇👇👇

Dislocating the shoulders of giants… 😒

Oded Rechavi@odedrechavi.bsky.social · 3mo ago

Gloves are off! TODAY WE RELEASE THE 1% A list of the year’s very best papers 👇 (see thread)

Epigenetics means different things for different people. In this workshop we will discuss two major views anchored on transcriptional memory: chromatin vs networks. Come and share with us our excitement for the topic and the magnificent place, the Andalusian Baeza. urldefense.com/v3/__https:/...

Workshop Transcriptional memory in health and disease

The idea that cells remember past states to prepare their future endeavors has split into two parallel languages that rarely converse. On one side, chromatin epigenetics defines inheritance through th...

urldefense.com

Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...

🚨Preprint🚨 An unexpected source of sex hormones in mammalian gonads: Supporting-like cells (SLCs) 🐇 SLCs have latent steroidogenic potential and may be an ancestral lineage conserved beyond mammals Led by @ivan-barbera-aura.bsky.social & V Chung Bluetorial 1/15👇 www.biorxiv.org/content/10.6...

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity

What should Europe do when demand for #ERC funding keeps rising? Restrict access or invest in excellence? Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness Consider to share & sign - see below 🧪

#erc | Johanna Joyce

What should Europe do when demand for its most successful frontier research programme keeps rising? Restrict access, or invest in the excellence it has created? A new open letter, spearheaded by Sara...

linkedin.com

Join us at the Mammalian Reproduction GRC conference next August in Maine! We have a fantastic line of speakers and free slots for talks selected from abstracts. Don't miss it! www.grc.org/mammalian-re...

CREsted is finally out! You can find the article, together with a summarizing Research Briefing, in thread. 🦎

Nature Methods@natmethods.nature.com · 6mo ago

CREsted: an efficient and user-friendly toolbox for analysis, modeling and design of cell-type-specific enhancers. www.nature.com/articles/s41...

👩‍🔬Conoce a Patricia Altea investigadora del @cabimer.bsky.social , Premio Nacional de Investigación para Jóvenes en Medicina y Ciencias de la Salud 🔬 Destacada por sus trabajos sobre traslación de mecanismos moleculares en dianas farmacológicas

Patricia Altea Manzano, PNI para Jóvenes Gabriella Morreale en Medicina y Ciencias de la Salud

Patricia Altea es investigadora Ramón y Cajal y ERC Starting Grant en el Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER en Sevilla (cen...

youtube.com

Registration for the 19th meeting of the #SEBD is now open! Please join us at El Rompido for 3 days full of excellent #DevBio and plenty of opportunities to present your work at #SEBD2026 share.google/2llY3VlS5fQA...

Do you do a PhD on Chromatin in this cool critter? Work with @jordisolana.bsky.social @seanflynn.bsky.social, Magda Strauss and myself @lsiexeter.bsky.social on developing #singlecell #chromatin analyses to better understand pluripotency #planarians. www.exeter.ac.uk/research/ins...