Sailing in @biorxivpreprint.bsky.social ready for summer, our study on the iconic Portuguese man o' war 🪼 is out: www.biorxiv.org/content/10.6.... We use (epi)genomics to understand a critter that fascinates me since childhood. Massive team effort with @obog.bsky.social, Cummins and Neely groups. 🧵

🫵🏼 If you want to do a PhD studying this wonderful creature of the pic, WE ARE NOW HIRING 💰!! Go to our profile for more info ℹ️. Postdocs are also welcome to get in touch!! 👇🏼👇🏼👇🏼👇🏼

Genetics UB@geneticsub.bsky.social · 7d ago

🎨 We merge science and art in our #PicOfTheMonth at @geneticsub.bsky.social 🔬 The image shows a lateral view of the trunk of an adult Oikopleura dioica, the closest living invertebrate relative to humans and other vertebrates. 📸 by @alfonso233.bsky.social @evodevogenomeub.bsky.social

Thank you @natgenet.nature.com for this nice Research Briefing www.nature.com/articles/s41... on our recent paper reporting live-cell measurements of Sox2 promoter bursting kinetics when varying its genomic distance from the SCR enhancer 👉 www.nature.com/articles/s41...

The genomic position of an enhancer modulates bursting dynamics of the cognate promoter - Nature Genetics

We show that, in a genomic locus with minimal complexity, the distance between promoter and enhancer modulates the frequency of clustered transcriptional bursts. Thus, besides the nucleotide sequence,...

nature.com

The third chapter in our coral single-cell trilogy is here. After mapping cell type diversity in Stylophora (Levy 2021) and exploring facultative symbiosis in Oculina (Levy 2025), we now uncover cell type-specific responses to heat stress. Find out more in @xgrau.bsky.social's thread below.

Cell-resolved transcriptional responses during heat-induced coral bleaching and recovery

Coral reefs depend on an intracellular symbiosis between cnidarian hosts and photosynthetic dinoflagellates that is disrupted by ocean warming, causing coral bleaching. Yet how these responses are dis...

biorxiv.org

Xavier Grau-Bové 🌾@xgrau.bsky.social · 2w ago

I'm happy to share our latest on #coral single-cell biology: a transcriptomic timecourse of heat stress in Stylophora pistillata, from bleaching to recovery 🪸🌊 This project was spearheaded by Shani Levy and carried through in @arnausebe.bsky.social's lab at @crg.eu. www.biorxiv.org/content/10.6...

Our latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells. www.nature.com/articles/s43...

Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program - Nature Aging

Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

nature.com

🚨 Job Alert - Please share 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! ✅ 4 years fully funded PhD position 💻🧪 Experimental or computational backgrounds welcome 👇 Details below #PhDPosition #PhDOpportunity #AcademicJobs

Beautiful

Oisín McGann@oisinmcgann.bsky.social · 3w ago

I don’t know why this post doesn’t give his name, but it’s Jo Nagai. This is a true story. medium.com/@zehraanjum2...

Our new paper is out in @nature.com! We uncovered how a naked mole-rat queen 👑 controls an entire colony: a natural contraceptive scent that suppresses reproduction in other females! A remarkable mammalian parallel to bees and ants! 🐝🐜 @garyrlewin.bsky.social youtu.be/enfv3zJrWKM?...

Naked mole-rats are ruled by a queen: this chemical puts her in power

YouTube video by nature video

youtu.be

🚨 Early Bird registration and abstract submission deadline for #SEBD2026 extended!! 📅 Early registration and abstract submission deadline: 10th July 📅 Scholarship application deadline: 29th June www.sebd2026.com #SEBD #DevBio @sebioldev.bsky.social 👇👇👇

Dislocating the shoulders of giants… 😒

Oded Rechavi@odedrechavi.bsky.social · last mo.

Gloves are off! TODAY WE RELEASE THE 1% A list of the year’s very best papers 👇 (see thread)

Epigenetics means different things for different people. In this workshop we will discuss two major views anchored on transcriptional memory: chromatin vs networks. Come and share with us our excitement for the topic and the magnificent place, the Andalusian Baeza. urldefense.com/v3/__https:/...

Workshop Transcriptional memory in health and disease

The idea that cells remember past states to prepare their future endeavors has split into two parallel languages that rarely converse. On one side, chromatin epigenetics defines inheritance through th...

urldefense.com

Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...

🚨Preprint🚨 An unexpected source of sex hormones in mammalian gonads: Supporting-like cells (SLCs) 🐇 SLCs have latent steroidogenic potential and may be an ancestral lineage conserved beyond mammals Led by @ivan-barbera-aura.bsky.social & V Chung Bluetorial 1/15👇 www.biorxiv.org/content/10.6...

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity

What should Europe do when demand for #ERC funding keeps rising? Restrict access or invest in excellence? Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness Consider to share & sign - see below 🧪

#erc | Johanna Joyce

What should Europe do when demand for its most successful frontier research programme keeps rising? Restrict access, or invest in the excellence it has created? A new open letter, spearheaded by Sara...

linkedin.com

Join us at the Mammalian Reproduction GRC conference next August in Maine! We have a fantastic line of speakers and free slots for talks selected from abstracts. Don't miss it! www.grc.org/mammalian-re...

CREsted is finally out! You can find the article, together with a summarizing Research Briefing, in thread. 🦎

Nature Methods@natmethods.nature.com · 4mo ago

CREsted: an efficient and user-friendly toolbox for analysis, modeling and design of cell-type-specific enhancers. www.nature.com/articles/s41...

👩‍🔬Conoce a Patricia Altea investigadora del @cabimer.bsky.social , Premio Nacional de Investigación para Jóvenes en Medicina y Ciencias de la Salud 🔬 Destacada por sus trabajos sobre traslación de mecanismos moleculares en dianas farmacológicas

Patricia Altea Manzano, PNI para Jóvenes Gabriella Morreale en Medicina y Ciencias de la Salud

Patricia Altea es investigadora Ramón y Cajal y ERC Starting Grant en el Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER en Sevilla (cen...

youtube.com

Registration for the 19th meeting of the #SEBD is now open! Please join us at El Rompido for 3 days full of excellent #DevBio and plenty of opportunities to present your work at #SEBD2026 share.google/2llY3VlS5fQA...

Do you do a PhD on Chromatin in this cool critter? Work with @jordisolana.bsky.social @seanflynn.bsky.social, Magda Strauss and myself @lsiexeter.bsky.social on developing #singlecell #chromatin analyses to better understand pluripotency #planarians. www.exeter.ac.uk/research/ins...

The 2026 call for the José Luis Gomez-Skarmeta award of excellence in #DevBio is now open! If you’d like to join the previous awardees @dariloops.bsky.social 2024 and @mirimiam.bsky.social and @radaiglesiaslab.bsky.social 2022, please don’t hesitate to apply to #JLGS2026

📢📢 join us for this edition of the “Quantitative biology to molecular mechanisms” EMBO workshop Gene regulation, cell dynamics & systems biology 17th - 20th November More info: s.embl.org/omx26-01-bl

Quantitative biology to molecular mechanisms

s.embl.org

Mike Dorrity@mwdorr.bsky.social · 5mo ago

The time has come for another round of QBMM - we have a fantastic lineup of speakers in genomics, systems biology, and modeling cell dynamics. Check it out! Co-orgs @elowitzlab.bsky.social @tinekelenstra.bsky.social @trayon.bsky.social @savitski-lab.bsky.social and I look forward to seeing you

Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS 🧬 🧪 To learn about ➡️ Dynamics of immunological tissue architecture in the human gut ⬅️ by ⭐ professor Simon Koplev ⭐ from KTH @scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social REGISTER NOW! www.trippus.net/summerschool...

Summer School 2026

Come to this beautiful Swedish inland scenario to learn the most advanced technologies to study transcriptional regulation.

trippus.net

Claudio Cantù@claudiocantu81.bsky.social · 4mo ago

Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS To learn Enhancer dynamics in living Drosophila embryos by ⭐ prof Takashi Fukaya⭐ @fukayalab.bsky.social @utokyoofficial.bsky.social @kawresearch.bsky.social @scilifelab.se @remeseiro-lab.bsky.social REGISTER www.trippus.net/summerschool...

🏝️ In Crete island, enjoying the iconic Vertebrate Sex Determination Synposium @biol-vsd.bsky.social Thanks to the organizers for the invitation and especially to @nitzan-gonen.bsky.social & Humphrey Yao for making this meeting a reality

Come and join us at Karolinska Institutet! We are recruiting computational/wet-lab postdocs to the Kragesteen lab to decipher gene regulation of oxygen homeostasis using organoids/hypoxia mouse models coupled with CRISPR and sc/st omic readouts 🏔️🩸🧬🧫 Apply by 7th April: ki.varbi.com/what:job/job...

Two postdoc postions - one computational and one wet lab – in Hypoxia Biology and Genome Regulation

Vill du bidra till medicinsk forskning av toppkvalitet? Kom och bli en del av Kragesteens grupp vid institutionen för Medicinsk Biokemi och Biofysik (MBB) på Karolinska Institutet /Biomedicum och va

ki.varbi.com

🤓 Important work from @dewitlab.bsky.social showing distinct functions of CTCF during development. Congrats to all authors!

Elzo de Wit lab @ NKI@dewitlab.bsky.social · 5mo ago

🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...

👇We continue accepting applications for open PhD and Postdoc positions in our lab @cabd-upo-csic.bsky.social ✉️ Get in touch if you are interested in joining our lab in the beautiful city of Seville @csic.es @pablodeolavide.upo.es

Darío Lupiáñez@dariloops.bsky.social · 5mo ago

🚨 Job Alert - Please share! 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! We’re recruiting: ✅ PhD students ✅ Postdocs 💻🧪 Experimental or computational backgrounds welcome 👇 Details below

✉️ Research Briefing by @mamartirenom.bsky.social and I on our recent study, where we employ a new method, METALoci, to explore the 3D regulatory landscape of sex determination. 👏Thanks to @mcgambetta.bsky.social & @dimitristypas.bsky.social for their insights. 👉 Full manuscript: rdcu.be/e5sm2

Nature Structural & Molecular Biology@natsmb.nature.com · 5mo ago

ICYMI: New online: Charting the 3D regulatory landscape of sex determination with geostatistics

Ever wondered how a eukaryotic transcription factor finds its specific DNA motif in the vast genome? In this preprint, we directly measured the dynamics of this search process in living cells, revealing a cooperative mechanism mediated by disordered regions. 1/10 doi.org/10.64898/202...