It's been 30 years (!!!) since the conceptualization of GWAS. GWAS has driven tons of discoveries, but with recent experimental developments (CRISPR, single-cell omics), we thought it was time to think about how to drive the next 30 years of human genetics. doi.org/10.5281/zeno...

I've complained on here a few times about synteny plots that are harder to read than they need to be. I decided it was time to actaully do something about it: introducing SynTangle, a tool for untangling whole-genome synteny plots github.com/Hanliconius/... 1/

GitHub - Hanliconius/SynTangle: On synteny plots, intrinsic tangledness is real, layout tangledness is noise. This tool is for removing layout tangledness.

On synteny plots, intrinsic tangledness is real, layout tangledness is noise. This tool is for removing layout tangledness. - Hanliconius/SynTangle

github.com

Joe Hanly@hanliconius.bsky.social · last mo.

I hate to do this with real data, but this is a persistent data vis issue in chromosome synteny riparian plots that we Need to get better at. Left, a synteny plot published today. Right, a rearranged version with exactly the same gross arrangement but with reordered chromosomes:

Aujourd'hui, on quitte l'époque contemporaine, mais rappelons-nous du 17 octobre 1961 et du massacre mené par la police des Algérien·nes qui manifestaient pacifiquement. Invisible pendant longtemps, le film "Octobre à Paris" de Jacques Panijel constitue un document précieux de cette répression

Christian Robert reviews Bayesian Workflow, suggests the abbreviation BaWoFlow. xianblog.fr/2026/10/08/b...

Bayesian workflow [book review]

“This original, thought-provoking, and transforming, book is much much more than an implementation manual for Bayesian Data Analysis, even though it shares almost the same perspective. (The f…

xianblog.fr

A population genetics study investigates how genetic variation is maintained in a polygenic trait under stabilizing selection in a subdivided population. Learn more in #GENETICS 🔗 buff.ly/cDuTqm4

I hate to do this with real data, but this is a persistent data vis issue in chromosome synteny riparian plots that we Need to get better at. Left, a synteny plot published today. Right, a rearranged version with exactly the same gross arrangement but with reordered chromosomes:

This must be the place: deep learning local adaptation https://www.biorxiv.org/content/10.64898/2026.09.16.752190v1

Congratulations to @rpianezza.bsky.social @rokofler.bsky.social, Matt Beaumont and Sarah Saadain! We found an endogenous retro virus currently invading D. melanogaster!

super proud - my very first review is online www.annualreviews.org/content/jour... many thanks to @signor-molevol.bsky.social @rpianezza.bsky.social @almoroscarpa.bsky.social for the fun collaboration

The History of Transposable Element Invasions in Drosophila melanogaster

As a fundamental biological principle, genomic information is typically transmitted vertically from parent to offspring. Occasionally, however, genetic material is transferred horizontally between spe...

annualreviews.org

All four books I've co-authored are freely available online for non-commercial use: - Bayesian Workflow at avehtari.github.io/Bayesian-Wor... Links to other three books are in the quoted post 👇 (too many books to fit in one post!)

Bayesian Workflow book: Website – Bayesian Workflow book

Website for the Bayesian Workflow book by Gelman, Vehtari, McElreath, et al. — case studies, code, and exercises in R and Stan.

avehtari.github.io

Aki Vehtari@avehtari.bsky.social · 2y ago

All three books I've co-authored are freely available online for non-commercial use: - #Bayesian Data Analysis, 3rd ed (aka BDA3) at stat.columbia.edu/~gelman/book/ - #Regression and Other Stories at avehtari.github.io/ROS-Examples/ - Active Statistics at avehtari.github.io/ActiveStatis...

Working with minimal genomic samples from two species? I’ve put together DemogFit, a small R package for fitting IM models and estimating gene flow parameters from a single whole-genome sample per species, plus a Snakemake pipeline to generate the input files. github.com/LeebanY/Demo...

Nice. watchgen.readthedocs.io/en/latest/ph...

For those interested in invasion biology, this review discusses new approaches for testing the Anthropogenically Induced Adaptation to Invade (AIAI) hypothesis using population genomics and environmental genomic analyses. doi.org/10.1016/j.tr...

Can habitat modification in the native range promote invasion?

The anthropogenically induced adaptation to invade (AIAI) hypothesis posits that selection in human-modified habitats within native ranges can adapt p…

sciencedirect.com

I'm not sure if video is your thing, but this really helped me get a sense of it youtu.be/z64a7USuGX0?...

What the Books Get Wrong about AI [Double Descent]

YouTube video by Welch Labs

youtu.be

How good is MiniBWA, the successor to BWA? To test it, I ran MiniBWA on sequencing from 76 different species, comparing mapping speed, rate and accuracy with BWA MEM. In short, it's really good. If you map short reads, it's well worth your time. andrewcarroll.github.io/2026/06/30/t...

A short, informal intro to Drosophila genetics (with a French accent 🇫🇷): key concepts & techniques for new lab members. www.epfl.ch/labs/lemaitr...

Short Introduction to Drosophila_Engl

If you like French accent:A short and informal introduction to Drosophila genetics, covering the basic knowledge and techniques that may be helpful when working with Drosophila. This series of short l...

epfl.ch

Current bwa-mem users are encouraged to try minibwa as minibwa is planned to replace bwa-mem (but not minimap2). Source code: * minibwa in C: github.com/lh3/minibwa * minibwa-rs (Rust rewrite by AI): github.com/henriksson-l...

GitHub - lh3/minibwa: Successor of bwa-mem for short-read alignment

Successor of bwa-mem for short-read alignment. Contribute to lh3/minibwa development by creating an account on GitHub.

github.com

Minibwa is a hybrid of bwa-mem and minimap2 and the successor of bwa-mem for short-read mapping. ~4X/2.5X as fast as bwa-mem/bwa-mem2 for WGS reads at comparable accuracy. Native support of directional bisulfite-seq. Applicable to long reads. Preprint at arxiv.org/abs/2606.15357

Recipe for a Good π. How to Properly Estimate Population Genetics Summary Statistics and Why we Should Systematically Report Them academic.oup.com/gbe/article/...

A Recipe for a Good π. How to Properly Estimate Population Genetics Summary Statistics and Why we Should Systematically Report Them

Abstract. Many long-standing questions in population genomics can now be addressed through comparative analyses and by leveraging the vast amount of genomi

academic.oup.com

Pine Processionary Moth chromosome-level #genome Assembly by @mgda76.bsky.social, @prrnhd.bsky.social et al. in Journal of Heredity @theaga.bsky.social. 615.9 Mb 50 pseudochromosomes 12,898 annotated genes @cbgpmontpellier.bsky.social academic.oup.com/jhered/artic...

The concise history of modeling character evolution. Handy timeline. academic.oup.com/sysbio/advan... 🧪 #EvoBio #Paleobio

Save the date! The 17th DrosEU workshop will be held in České Budějovice on the 24th to 26th May 2027. Thanks to @janhreck.bsky.social for hosting us! #Drosophila #genomics

Rammap: github.com/jwanglab/ram... Minimap2 v2.31: github.com/lh3/minimap2...

GitHub - jwanglab/rammap: An extensible and performant aligner and read mapper

An extensible and performant aligner and read mapper - jwanglab/rammap

github.com

The Drosophila melanogaster Genetic Reference Panel, Version 3 (DGRP3) https://www.biorxiv.org/content/10.64898/2026.05.29.728783v1

David Reich – Why the Bronze Age was an inflection point in human evolution • "Instead of being quiescent, natural selection is everywhere."

David Reich – Why the Bronze Age was an inflection point in human evolution

"Instead of being quiescent, natural selection is everywhere."

dwarkesh.com

This is really big (if it works!)—a big limitation for the use of R in simulation up to this point has been memory bloat. I’ve had to turn off parallel processing/reduce the number of workers many times in my {targets} workflows due to OOM errors. Hopefully this will solve that problem #RStats

Charlie Gao@shikokuchuo.net · 7mo ago

Just released mori 0.1.0 on CRAN — a new R package for shared memory across processes. Parallel R no longer has to mean duplicating your dataset in every worker's RAM. opensource.posit.co/blog/2026-04... 🧵 1/3

Johnson et al. analyse the genomic signatures of fluctuating selection and introduce statistical strategies for distinguishing it from other modes of selection in population genetic studies. 🔗 doi.org/10.1093/gbe/evag082 #genome #evolution

Genetic Footprints of Seasonal Fluctuating Selection: A Comparison With Established Selection Forms

Abstract. Fluctuating selection is frequently studied in natural populations by observing allele frequency trajectories over evolutionarily brief timeframe

doi.org

Reposting this old thread on the "Pervasive findings of directional selection" from ancient DNA. While the authors extended their results in various ways, I think many of these points still stand.

Graham Coop@gcbias.bsky.social · 2y ago

My lab read this paper www.biorxiv.org/content/10.1... for journal club, and had some thoughts on the strong claims made about the number of signals of selection found.

The 16th DrosEU Meeting kicks off this Monday, April 13! 🧬 A great scientific program and discussions await: droseusuz.sciencesconf.org #DrosEU2026 @droseu.bsky.social With support from @occitanie.bsky.social, @umontpellier.bsky.social, GIS Fruit, IGH, GenoPolys, and @sfgenetique.bsky.social

🪰 🧬16th #DrosEU2026 Workshop & Satellite #DrosophilaSuzukii Meeting Conference will take place 13–17 April 2026 in #Montpellier, France 🇫🇷. We look forward to connecting with colleagues across Europe to discuss new research in #Drosophila #genomics #evolution & #CitizenScience +info 👉 droseu.net