Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n

Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science. Today @nature.com, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/

Brain vascular aging isn’t a single path. Our new work shows that the aging brain diverges into two states: 🧠 Hypovascular (expected) 🧠 Hypervascular (surprising), with BBB leakage, inflammation and cognitive decline. Our study👇🏻: www.biorxiv.org/content/10.6...

Now online in Cancer Discovery @aacrjournals.bsky.social: LPL-Positive Endothelial Cells Control T-cell Homing in Liver Metastasis - by Xiaowen Zhang, Mahak Singhal, @hellmutaugustin.bsky.social, and colleagues doi.org/10.1158/2159... @dkfz.bsky.social @uniheidelberg.bsky.social

Congratulations to Xiaowen Zhang for her spectacular publication in Cancer Discovery identifying a subpopulation of LPL-expressing intratumoral endothelial cells that decisively controls the anti-tumor immune response in liver metastases. See: aacrjournals.org/cancerdiscov...

1/ My PhD work is finally out in @natgenet.nature.com ! 🎉 We introduce SelectSim and map co-mutations across >70,000 tumors and 100+ cancer types and subtypes. Cancer mutations do not act in isolation; their combinations can shape tumor evolution. www.nature.com/articles/s41...

Evolving patterns of co-mutations from tumor initiation to metastatic progression - Nature Genetics

SelectSim uses cancer and healthy tissue sequencing datasets to identify co-mutations that occur more or less frequently than would be expected by chance. Differences in co-mutation patterns observed ...

nature.com

Sensory neurons encode long-term inflammatory memory that promotes gastric regeneration and tumorigenesis https://www.biorxiv.org/content/10.64898/2026.06.15.732199v1

Sex-Dimorphic Neural Memory Shapes Pancreatic Tissue Resilience https://www.biorxiv.org/content/10.64898/2026.06.15.732370v1

Incredible to see our work out today in Cell: "Plasma signals of lung tumor promotion for molecular cancer prevention." www.cell.com/cell/fulltex...

Plasma signals of lung tumor promotion for molecular cancer prevention

A 14-protein plasma signature identifies individuals benefiting from anti-IL-1β-based lung cancer risk reduction and demonstrates how diverse tumor-promoting factors converge on the induction of an al...

cell.com

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://nej.md/4nWaxvM #ASCO26

Thrilled to share our new paper out today in @NatureCancer:A single dose of RT makes CAR T cells work against extensive metastatic lung cancer — even when the target antigen is also on normal tissues. (1/14) nature.com/articles/s43018-026-01167-6

Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases - Nature Cancer

Ahmed and colleagues show that, by promoting ‘dressing’ of intact tumor target antigens onto dendritic cells, tumor irradiation enhances chimeric antigen receptor T cell persistence and efficacy in lu...

nature.com

Researchers at the Crick have uncovered how lung tumours can hijack the activity of nearby nerves to weaken the body’s immune response. This research was led by Ya-Hsuan Ho and Giacomo Bregni, with corresponding author Leanne Li. www.crick.ac.uk/news/2026-05...

Nerve signals disrupt immune response to lung cancer

Sensory nerve activity disrupts how immune cells are organised within lung tumours, weakening the immune response.

crick.ac.uk

Happy #FluorescenceFriday! Gap junction inhibition disconnects tumour networks in brain metastases and silences Ca²⁺ oscillations that drive proliferation. More in our recent preprint : www.biorxiv.org/content/10.6...

Our new preprint on calcium signaling in brain metastases is now on bioRxiv! Thrilled to share the core work of my doctoral thesis in the @winklerlab.bsky.social, together with @nielsolshausen.bsky.social, @matthiakarreman.bsky.social and many more!

Matthia Karreman@matthiakarreman.bsky.social · 3mo ago

What if brain metastatic cells do not act alone, but form #networks to help them grow? In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling. www.biorxiv.org/content/10.6... 🧵👇

Excited to share our ‘Evolutionary characterization of lung cancer metastasis’ in #TRACERx & #PEACE, published today in @nature.com in collaboration with @charlesswanton.bsky.social @nickymcgranahan.bsky.social @zaccasimo.bsky.social at @ucl.ac.uk & @crick.ac.uk. www.nature.com/articles/s41...

Evolutionary characterization of lung cancer metastasis - Nature

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

nature.com

How does the nervous system influence cancer ... and vice versa? Now online @cp-cell.bsky.social our newest review on current and emerging topics in Cancer Neuroscience 🧠, and many new exciting directions ahead. www.sciencedirect.com/science/arti...

The UK rejoining Erasmus is the best science news for a while! #AcademicSky www.gov.uk/government/n...

UK and EU finalise agreement to bring UK into Erasmus+ in 2027

Thousands across the UK set to benefit from re-opening of the historic Erasmus+ programme

gov.uk

Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression @cellcellpress.bsky.social www.cell.com/cell/fulltex...

Here are a couple of examples. Lung cancer survival rates for EGFR+ mutated Lung cancer.

It’s well known that inflammation increases cancer risk, but how? The answer: the epigenome "remembers" inflammation and primes stem cells for cancer. Here is our paper: nature.com/articles/s41... And a special shoutout to the lead author @snaga13.bsky.social A 🧵

Epigenetic memory of colitis promotes tumour growth - Nature

Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

nature.com

🔬 Watch how cancer and immune cells interact in a living system. Scientists at BCI have developed mini lab-grown ovarian tumours that recreate the complex neighbourhood of cells in patients. Published today in @natcomms.nature.com. Read more: bit.ly/4bMCrVg 🧪 #medsky #oncosky @qmul.bsky.social

AP-1 mediates cellular adaptation and memory formation @natcomms.nature.com @pennmedicine.bsky.social @arjunraj.bsky.social @penngenetics.bsky.social www.nature.com/articles/s41...

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis

Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

science.org

Humanity is notorious for leaving problems for the next generations, but animals reveal the biology: C. elegans develop germline tumors if THEIR GRAND GRANDPARENTS’ cells fail to clear garbage from their body cavity… What the hell, you ask? Read our new preprint! 👇 www.biorxiv.org/content/10.6...

Two Crick group leaders are joining Cancer Grand Challenges teams to tackle big questions in cancer research. Leanne Li leads a team studying how tumours interact with the nervous system, and Vivian Li joins a @ucl.ac.uk-led team working to rewire cancer cells. 🔗 www.crick.ac.uk/news/2026-03...

@simoncleary.bsky.social, Longhui Qiu, Mark Looney et al. developed a new #intravital technique for imaging pulmonary lymphatics. rupress.org/jem/article/... 📘 In our #Lymphatics collection: rupress.org/jem/collecti...

This week, we're joined by @drwilliamhill.bsky.social from @cruk-mi.bsky.social for the next in our @britsocimm.bsky.social MIG Seminar series: "Signals and Mechanisms of Lung Cancer Promotion by Air Pollutants” 📆 Thursday 19th Feb 🕛 12:00 PM 📍 Michael Smith Lecture Theatre #ImmunoSky

“Trust in scientists is gone!” Maria Leptin points to USA, adding: “To be resilient we must trust that the best researchers know where the scientific frontiers lie and keep diversity in research now for our future. Blue sky science is key to be prepared.” BMW Foundation Energy Security Hub

European Research Council (ERC)@erc.europa.eu · 6mo ago

Live from Munich! At 17:50, watch topical session at BMW Foundation Energy Security Hub - ahead of Munich Security Conference. 🎥 www.bmw-foundation.org/events/Energ... #MSC2026

The February issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features work by @danielazorin.bsky.social, Dirk Hoffmann, Sophie Heuer, Frank Winkler, et al. on targeting tumor microtubes to disrupt GBM cell networks. Read that & more: aacrjournals.org/cancerdiscov...

Roychoudhuri Lab@roychoudhurilab.bsky.social · 6mo ago

Absolutely remarkable: striking effects of infusion time-of-day on immunochemotherapy efficacy in nonsmall cell lung cancer in a randomized phase 3 trial www.nature.com/articles/s41...