📢 #CancerNeuroscience Online Seminar with Manuel Valiente from CNIO, Madrid, Spain. Title: Molecular and cellular rationale underlying the heterogeneous impact of metastases on brain activity June 9, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...

Happy #FluorescenceFriday! Gap junction inhibition disconnects tumour networks in brain metastases and silences Ca²⁺ oscillations that drive proliferation. More in our recent preprint : www.biorxiv.org/content/10.6...

Super excited to see our new preprint on calcium signalling in brain metastases now out on bioRxiv! Very thankful to be part of @winklerlab.bsky.social and working so closely with @nilshebach.bsky.social under the guidance of @matthiakarreman.bsky.social and Frank Winkler and all our collaborators.

Matthia Karreman@matthiakarreman.bsky.social · 3mo ago

What if brain metastatic cells do not act alone, but form #networks to help them grow? In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling. www.biorxiv.org/content/10.6... 🧵👇

Our new preprint on calcium signaling in brain metastases is now on bioRxiv! Thrilled to share the core work of my doctoral thesis in the @winklerlab.bsky.social, together with @nielsolshausen.bsky.social, @matthiakarreman.bsky.social and many more!

Matthia Karreman@matthiakarreman.bsky.social · 3mo ago

What if brain metastatic cells do not act alone, but form #networks to help them grow? In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling. www.biorxiv.org/content/10.6... 🧵👇

What if brain metastatic cells do not act alone, but form #networks to help them grow? In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling. www.biorxiv.org/content/10.6... 🧵👇

Enjoy! This is such a great program, and a game changer in so many ways. Looking forward to seeing what is next!

Hertie Network (Hamburg site)@hertieneurosci.bsky.social · 4mo ago

🚀 A fantastic start to our 3rd funding period! Inspiring #HertieNetwork Symposium in Berlin during the last two days. So many opportunities for exchange, collaboration, and fresh ideas 🤝🧠 Scientific excellence across diverse disciplines in brain research - excited for what’s ahead! ✨

What are the current and emerging topics in Cancer Neuroscience, and what comes next for the field? In our new review, now online @cp-cell.bsky.social, we discuss previous and ongoing research from leading laboratories and propose future directions for research. 🧠🔬 Curious? See link below 😀👇

Cancer neuroscience: The past, the present, and the road ahead

Both the nervous system and cancer-intrinsic neural features can govern cancer initiation, growth, progression, metastasis, and treatment resistance, …

sciencedirect.com

How does the nervous system influence cancer ... and vice versa? Now online @cp-cell.bsky.social our newest review on current and emerging topics in Cancer Neuroscience 🧠, and many new exciting directions ahead. www.sciencedirect.com/science/arti...

📢 Registration (free!) for the NCI webinar series 'Fueling Cancer Progression by the Nervous System' is open! 🧠🔬 Amongst many excellent speakers, Frank Winkler and @venkatesh-lab.bsky.social discuss #cancerneuroscience of #brainmetastasis 📅 6 exciting topics are covered by leaders in the field 💡!

Thank you for the amazing #CancerNeuroscience conference @helloeacr.bsky.social! We had a great time in Bilbao @winklerlab.bsky.social🧠.

Very much looking forward to presenting our work on the #cancerneuroscience of #brainmetastasis in session OS10 later today #EANO2025 ! #preclinical #NeuroOncology

EANO@eanoassociation.bsky.social · 10mo ago

The second day of EANO 2025 in Prague begins – featuring a full schedule of high-level science, clinical innovation, and exchange across all disciplines in #NeuroOncology. See what’s on today 👉 eano.eu/eano2025/pro... #Immuntherapy #Gliom #Neurosurgery #Youngsters #Radiotherapy #FamilyFocusedCare

We want to say a huge thank you to all who attended and helped organise Cancer Neuroscience this week in Bilbao 🎉 The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...

We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature

Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...

nature.com

My main PhD project is out in #CancerDiscovery @theaacr.bsky.social We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy. Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!

Winkler Laboratory@winklerlab.bsky.social · 10mo ago

How to disconnect therapy-resistant tumor networks in glioblastoma? In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy. doi.org/10.1158/2159...

A new step towards targeting #tumornetworks in #glioblastoma ! Very happy to have made a small contribution to this exciting work led by @danielazorin.bsky.social and @dirkchoffmann.bsky.social 💐 #cancerneuroscience #GBM #braintumors 🧠 For a #Bluetorial see 👇

Winkler Laboratory@winklerlab.bsky.social · 10mo ago

How to disconnect therapy-resistant tumor networks in glioblastoma? In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy. doi.org/10.1158/2159...

How to disconnect therapy-resistant tumor networks in glioblastoma? In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy. doi.org/10.1158/2159...

Cancer cells hijack neurons to promote their growth. Here (and how) neurons form pseudo-synapses to promote pancreatic cancer's growth cell.com/cancer-cell/...

and last but not least two cancer neuroscience papers on small cell lung cancer. 1. www.nature.com/articles/s41...

Functional synapses between neurons and small cell lung cancer - Nature

Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

nature.com

2. www.nature.com/articles/s41...

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature

Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...

nature.com

Wow congratulations, Mahak 🎊 , this is so well deserved !!!

Hellmut Augustin@hellmutaugustin.bsky.social · 11mo ago

Congratulations to Mahak Singhal @uniheidelberg.bsky.social on being awarded an @erc.europa.eu Starting Grant for his project "Vascular-Rhythm" focussing on "DeClocking the vascular rhythmic control of tissue homeostasis and disease initiation". Pioneering a new branch of vascular research!

Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨

Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth

Anastasaki and colleagues establish a previously unknown glutamate growth dependency in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial molecular circuits present d...

cell.com

How do #metastases survive (and thrive!) in the #brain microenvironment? In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases: Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠

Neuron@cp-neuron.bsky.social · 11mo ago

A Review by Frank Winkler & @matthiakarreman.bsky.social on how neural-cancer interactions shape metastasis and tumor evolution www.cell.com/neuron/fullt...

Shameless self promotion of our new paper. So very excited to share our new work uncovering coupling of glutamate receptors ⚡️and RTKs to enable growth of low-grade gliomas 🧠 @gutmannlab.bsky.social @washuneurology.bsky.social

Neuron@cp-neuron.bsky.social · 11mo ago

Online now:

How can we reawaken the body’s own anti-viral defenses to fight brain cancer? Delighted to share our new study where we now answer this question, led by the brilliant @alvarezprado.bsky.social who is now an independent PI at LIH Luxembourg 👏👏 #BrainTIME 🧠🦠🧪 🧵 www.sciencedirect.com/science/arti...

A Review by Frank Winkler & @matthiakarreman.bsky.social on how neural-cancer interactions shape metastasis and tumor evolution www.cell.com/neuron/fullt...

Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do

In this comprehensive review, Karreman & Winkler explore how neural influences on the brain’s metastatic process govern brain tropism, colonization, and growth. Conversely, metastatic cancer has disti...

cell.com

Very much looking forward to this meeting! Thank you for the invite to present our work here 🔬🐁🧠

German BioImaging@gerbi-gmb.de · 11mo ago

Check out the detailed program for the 5th Day of Intravital Microscopy (18–19 Sept, Tübingen)! Our keynote: @matthiakarreman.bsky.social‬: "Imaging cancer networks in brain metastases in vivo." Full details 👉 bit.ly/3IOlJtJ #IVMIC25

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

HER3-targeted patritumab deruxtecan showed efficacy in leptomeningeal metastases from solid tumors in the Phase II TUXEDO-3 trial 📉 65% 3-month survival 🧬 Activity in intracranial lesions 🔷 From Matthias Preusser, MD, et al 🔗 ascopost.com/news/july-20...

Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis https://go.nature.com/46c474I

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature

A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.

go.nature.com

‼️Good news! Deadline for late breaking abstract submission extended until July 1, 2025! Don't miss this opportunity to present your very latest reasearch breakthrough to the #NeuroOncology community at #EANO2025. Submit your abstract👉https://eano.eu/eano2025/abstracts/ #btsm #braintumor