The medial entorhinal spatial map is built on excitatory-inhibitory network motifs defined by their functional cell type and theta modulation https://www.biorxiv.org/content/10.64898/2026.07.02.735850v1
Wolf De Wulf
@wulfdewolf.bsky.social
PhD student @edinburgh-uni.bsky.social NeuroRSE intern @flatironinstitute.org NeuroAI intern @cshlnews.bsky.social Trying to understand spatial computation and memory in biological neural networks. I run a lot. wulfdewolf.github.io
It was an eager crowd! Many got to decoding head direction from population activity, some without having used Python before. Thanks for having me, and thanks as well to the @simonsfoundation.org for funding the development of packages like Pynapple (@guillaumeviejo.bsky.social & Sarah Jo Venditto)
Adrian Duszkiewicz@adrian-du.bsky.social · 2mo agoFantastic turnout at the @dns-uom.bsky.social's inaugural Neural Data Analysis Workshop, over 20 ECRs attending the talks and hands-on sessions 🧠💻⚡ Huge thanks to @wulfdewolf.bsky.social, @ennyvb.bsky.social and Chris Halcrow for walking us through their cutting-edge tools! Links in the comments👇
What happens when 18 teams of expert neuroscientists analyze the exact same neurophysiology dataset? You might expect convergence, but that is not what we found. Very grateful for the opportunity to write with Gaëlle Chapuis about one of my favorite projects since I started working in science! 1/n
The Transmitter @thetransmitter.bsky.social · 2mo agoA hackathon reveals that disagreement in neuroscience runs deeper than most researchers suspect—even in electrophysiology, a field that prides itself on hard data, write @mattiachini.bsky.social and Gaelle Chapuis. #neuroskyence www.thetransmitter.org/reproducibil...
Calling all fans of neuronal spikes at @manchester.ac.uk 🚨 Don't miss out on our first workshop on open-source tools for neural data analysis ⚡🧠 Speakers: @ennyvb.bsky.social (UCL), @wulfdewolf.bsky.social & Chris Halcrow (University of Edinburgh) Many thanks to @dns-uom.bsky.social for support!
🧠💻 Join the Brainhack satellite at #FENS2026 (July 5)! ✨ Open to all - no FENS registration required 📆 Registration opens April 9 ⚠️ Limited to 100 spots (first come, first served) Learn more: pre-fens-brainhack.github.io/brainhack2026/ #Brainhack #OpenScience #Neuroscience
If you analyse ephys/calcium in Python (or want to) this will be super useful for you! We remade our entire pipeline to use Pynapple (and NeMoS), and it was shockingly easy. I'll be TAing, and happy to discuss your specific analysis needs. bonus: le Tour de France starts in Barcelona that week!!!
Flatiron Institute@flatironinstitute.org · 4mo agoApply for #FlatironCCN's Neural Data Analysis workshop at #FENS2026 before April 10! Learn more: https://www.simonsfoundation.org/event/ccn_fens2026/ #science #neuroscience
Our new preprint on parallelizing training of temporally precise spiking neural networks is out! We show up to 44x speedups over a conventional sequential baseline. 1/N
1/7 🧠 My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! 🧵
Edvard I Moser@edvardmoser.bsky.social · 5mo agoIs spatial navigation innate 🧠? Using #NeuroPixels we show that the #torus 🍩 underlying the #GridCell map exists already on day 10 in rats — before pups open eyes and ears and before they start upright walking. 🧵1:4 👇 www.biorxiv.org/content/10.6...
The Cowley Group at CSHL has an opening for a bioAI PhD student to start Fall 2026 to work on closed-loop AI models for visual processing (see below). You *must* have a Master's degree in a quant/eng/cs field. www.cshl.edu/phd-program/... Please reach out to me if interested! I'll be at Cosyne.
BioAI PhD Program | Cold Spring Harbor Laboratory
Since 1890, Cold Spring Harbor Laboratory (CSHL) has been a global leader in research and education. The international scientific community at CSHL provides a unique and stimulating atmosphere for doc...
cshl.edu
Benjamin Cowley@benjocowley.bsky.social · 5mo agoDNN models of the brain are getting bigger. Are we replacing one complicated system in vivo with another in silico? In new work, we seek the *smallest* DNN models of visual cortex, balancing prediction with parsimony. It turns out these compact models are surprisingly small! rdcu.be/e5H8G
Join us at TENSS 2026 to open black boxes, explain how things/brains work and debate the impact (or lack or it) of various new technologies on understanding of the brain and on society. tenss.ro Apply by: March 15th!
DNN models of the brain are getting bigger. Are we replacing one complicated system in vivo with another in silico? In new work, we seek the *smallest* DNN models of visual cortex, balancing prediction with parsimony. It turns out these compact models are surprisingly small! rdcu.be/e5H8G
Compact deep neural network models of the visual cortex
Nature - Parsimonious deep neural network models can be used for prediction of visual neuron responses.
rdcu.be
Mission: record hippocampal place cells in zero gravity Crew: 3 rats with electrode arrays Vehicle: Space Shuttle Columbia Status: data now publicly available on DANDI, 28 years later The ratstronauts' mission is finally complete. 🐀🚀 h/t NASA about.dandiarchive.org/blog/2026/02...
Applications are now open for the summer school: 𝐌𝐚𝐭𝐡𝐞𝐦𝐚𝐭𝐢𝐜𝐚𝐥 𝐌𝐞𝐭𝐡𝐨𝐝𝐬 𝐢𝐧 𝐂𝐨𝐦𝐩𝐮𝐭𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 🧠 Apply before March 15: www.compneuronrsn.org 📍 Located in beautiful Eresfjord 🇳🇴 🗓️ Between July 6-24 Supported by the @kavlifoundation.org In collaboration with @kavlintnu.bsky.social
Mathematical Methods in Computational Neuroscience
Summer school in Eresfjord, Norway (July 8th - 26th, 2024)
compneuronrsn.org
Go fit some neural models!! JAX, Pynapple, Poisson GLMs; what more can you ever wish for...
Pynapple @pynapple.bsky.social · 6mo agoNeMoS 0.2.6 is out! ✅ ClassificationGLM for multi-class problems ✅ Gaussian & categorical observation models ✅ JIT-compiled bases for major speedups Full release notes: github.com/flatironinst...
Pre-COSYNE Brainhack 2026 – Join Us in Lisbon! March 10–11, 2026 • Lisbon, Portugal pre-cosyne-brainhack.github.io/hackathon2026/ Kick off COSYNE week with two days of hands-on, team-based hacking around real electrophysiology data, open tools, and reproducible workflows. #brainhack #cosyne2026
Pre-COSYNE Brainhack 2026
The 2026 edition of the Pre-COSYNE Brainhack in Lisbon, Portugal.
pre-cosyne-brainhack.github.io
Three weeks left to apply for the Neuroinformatics Unit Open Software Summer School, August 17-28 2026 in London, UK! Bringing together researchers and open source developers of ephys, behaviour and image analysis tools. neuroinformatics.dev/open-softwar... Deadline January 31st. Apply now!
Can humans & animals really use internal maps to take shortcuts? Tolman famously said yes - based largely on his Sunburst maze. Our new review & meta-analysis suggests evidence is far weaker than you might think. 🧵👇 doi.org/10.1111/ejn.... @uofgpsychneuro.bsky.social @ejneuroscience.bsky.social
Tolman's Sunburst Maze 80 Years on: A Meta‐Analysis Reveals Poor Replicability and Little Evidence for Shortcutting
In 1946, Tolman et al. reported that rats could take a novel shortcut to a goal after training on an indirect route, supporting the Cognitive Map theory. However, a review of subsequent Sunburst maze...
doi.org
Just published my review of neuroscience in 2025, on The Spike. The 10th of these, would you believe? This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more Enjoy! medium.com/the-spike/20...
2025: A Review of the Year in Neuroscience
Enlightening the brain
medium.com
A 🍍 spotted in the wild at @edinburgh-uni.bsky.social! Great crash course on neuro data processing with @pynapple.bsky.social and @spikeinterface.bsky.social delivered by @matthiashennig6.bsky.social, @wulfdewolf.bsky.social and Chris Halcrow. So nice to see both libraries working so well together
Really excited to share this Opinion piece we've been working on with fellow head-direction cell geeks @apeyrache.bsky.social @desdemonafricker.bsky.social and (bsky-less?) Andrea Burgalossi! While head-direction cells pop up in many cortical regions, we think that one of them is quite unique (1/8)
The postsubiculum as a head-direction cortex
The organisation of thalamocortical networks follows a conserved structure. Traditionally, these are divided into primary sensory systems that receive…
sciencedirect.com
We present our preprint on ViV1T, a transformer for dynamic mouse V1 response prediction. We reveal novel response properties and confirm them in vivo. With @wulfdewolf.bsky.social, Danai Katsanevaki, @arnoonken.bsky.social, @rochefortlab.bsky.social. Paper and code at the end of the thread! 🧵1/7
Finally preprinted! TL;DR: thalamic head-direction neurons can shape their activity regardless of input. Big thanks to @apeyrache.bsky.social and master experimentalist @sskromne.bsky.social .
Adrien Peyrache@apeyrache.bsky.social · 11mo ago🚨New preprint alert! The thalamus has long been seen as a relay of sensory signals to cortex. But could it also generate its own structured activity? Our study explores this question in the head-direction (HD) system. Some explanation 🧵👇 1/13 www.biorxiv.org/content/10.1...
New workshop! Just before SFN, join the Flatiron Institute Center for Computational Neuroscience of the Simons Foundation for a workshop on pynapple and NeMoS. Learn how to use these open-source packages to analyze and model neural data! Accommodation & meals provided. Link ⬇️
Excited to share our new pre-print on bioRxiv, in which we reveal that feedback-driven motor corrections are encoded in small, previously missed neural signals.
New paper from the lab: feedback from piriform cortex to the olfactory bulb carries identity and reward contingency signals in a multimodal (odor and sound) rule-reversal task. Feedback is re-formatted within seconds and reflects changes in the perceived rules of engagement. doi.org/10.1038/s414...
Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal - Nature Communications
Hernandez-Trejo, Ciuparu, and Garcia da Silva et al. report that the piriform-to-olfactory bulb feedback in the mouse carries multimodal identity and reward contingency signals, which are re-formatted...
doi.org
We are pleased to be partnering with The UKRI AI CDT in Biomedical Innovation at the School of Informatics (University of Edinburgh). These PhD projects have a strong translational focus and seek to develop & apply AI approaches to biomedical domains ✨. Apply by 20 Jan www.ai4biomed.io/how-to-apply/
Check our latest work towards understanding learning and local plasticity in the brain with @matthiashennig6.bsky.social at @edinburgh-uni.bsky.social 🧠 Published in a @neuripsconf.bsky.social workshop this year. Now out on arxiv - arxiv.org/abs/2501.02402
