Gary Patti
@gjpattij.bsky.social
metabophile (muh-tab-uh-fil'): a person obsessed with all things metabolism, metabolomics
First preprint from the lab, led by @gabbov.bsky.social! We identify a metabolic bottleneck that helps set the pace of human development: low levels of the redox enzyme GPD1L limit NADH recycling. Boosting GPD1L mimics mouse cells and accelerates development! www.biorxiv.org/content/10.6...
biorxiv.org
Of course this RFI drops late on Friday. NIH proposes to stop providing specific scores and instead bin grants into 3 broad categories: most competitive, competitive, not discussed. A score would be calculated but not provided to the PI (or PO). grants.nih.gov/grants/guide...
NOT-OD-26-088: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH
grants.nih.gov
🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year. That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027. A wonky bureaucratic problem with big implications. A short 🧵
Exclusive: key NIH review panels due to lose all members by the end of 2026
Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members.
nature.com
Dr. Mott is very good at her job, amazing work ethic, and thoughtfully protective of Congressional and scientific interests. A real hero, in my view... For background see www.asbmb.org/asbmb-today/...
Meet Meghan Mott
She’s living proof that policy fellowships are worthy of consideration.
asbmb.org
The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning. www.appropriations.senate.gov/news/majorit... 1/5
Committee Releases Conferenced Defense, Homeland Security, Labor, Health and Human Services, Education, and Related Agencies, and Transportation, Housing and Urban Development, and Related Agencies Bi...
United States Senate Committee on Appropriations
appropriations.senate.gov
This is an outstanding essay describing some of the important roles and influences of NIH program officers (from an insider perspective). Read! elizabethginexi.substack.com/p/the-quiet-...
The Quiet Power of Program Officers
How invisible decisions shape what science gets done—and whether it matters
elizabethginexi.substack.com
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
bioRxivpreprint@biorxivpreprint.bsky.social · 9mo agoOrganelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
There is apparently no point in checking out the "preview" to get ahead of the Biosketch game because it warns you that everything you fill in will be lost and you will have to start over when the real thing is rolled out. grants.nih.gov/grants/guide...
NOT-OD-26-018: NIHs Implementation of Common Forms for Biographical Sketch and Current and Pending (Other) Support for Due Dates on or after January 25, 2026
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: NIHs Implementation of Common Forms for Biographical Sketch and Current and Pending (Other) Support for Due Dates on or...
grants.nih.gov
Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups.
Drug Monkey@drugmonkey.bsky.social · 10mo agoHere we go. Its ALL #NIHGrant applications. Dec 8 is the new deadline. And a one page prelim data update will be accepted for all May Council submissions. grants.nih.gov/grants/guide...
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
science.org
Gut microbiota protect against hepatic steatosis by degrading sorbitol derived from dietary glucose @gjpattij.bsky.social www.science.org/doi/10.1126/...
6/ So what can you do? ✔️ Choose supplements that are third-party tested for heavy metals (USP, NSF, or Informed Sport). ✔️ Prioritize whole-food protein sources when possible. ✔️ Advocate for stronger supplement regulation as the industry has little oversight.
Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...
cell.com
1/ RFK Jr.’s promised autism “report” landed this week. Instead of new science, we got headlines, a press conference, and far-reaching claims drawn from decades of existing research. Parents and pregnant people were left with overwhelming anxiety. Here’s what the evidence actually says 👇
The Washington Post did a great job of summarizing a complex topic. There is still so much to learn about the connections between the exposome and cancer. Thanks for including me.
Eileen Clancy 🧿@clancyny.bsky.social · last yr.Gift link! Toxins, Tech and Tumors: Is Modern Life Fueling the Rise of Cancer in Millennials? By Ariana Eunjung Cha, Álvaro Valiño and Dan Keating @arianaec.bsky.social @alvarovalino.bsky.social and @dtkeating.bsky.social
Research in Scientific Reports suggests that blue-throated macaws can learn new actions by watching other macaws interact. The study indicates that this approach to learning is not exclusive to humans. go.nature.com/4g8p43m 🧪
I have a first serious attempt to estimate the consequences of multi-year funding for July. For new R01s, the amount of additional expenditure was $135 M The number of additional R01s that could have been funded is 182 1/9
a man in a shirt and tie is touching his forehead
ALT: a man in a shirt and tie is touching his forehead
media.tenor.com
Here are some of the highlights of the appropriations bill that the Senate appropriations committee just approved: $48.7 billion for NIH, an increase of $400 million Rejects the proposal to cap indirect cost rates at 15% Includes a provision to prevent MYF that would reduce the number of grants
appropriations.senate.gov
Even with flat funding for the NIH, under the current FY26 plan, there will be 60% less cancer research and much less research funded overall. We need to make sure Congress understands these tricks and protects against them in their budget plan.
Odds of winning NIH grants plummet as new funding policy and spending delays bite
Funding multiyear grants up front will sharply cut number of investigators receiving awards
science.org
1/ Since January, over 5,500 NIH-funded projects have been paused. That includes cancer trials, Alzheimer’s research, maternal health studies. This is work that directly impacts our lives. And people aren't talking about it enough. Let’s fix that 🧵
RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot. nationalmaglab.org/careers/meet...
Alan Marshall: A scientist and a Gentleman - MagLab
Meet one of the greatest innovators in the history of mass spectrometry, hard at work.
nationalmaglab.org
Join @drwendieberg.bsky.social for this half hour of discussion of supplemental breast cancer screening for women with dense breast tissue.
@drwendieberg.bsky.social · last yr.Join me on Sirius XM Doctor Radio (Channel 110) Monday 6/2/25 at 1:00-1:30 pm ET with Dr. Miriam Greene @nyulangone.bsky.social discussing @densebreastinfo.bsky.social and supplemental screening for women with dense breasts. Thank you @bcrfcure.bsky.social for supporting our research on CEM.
A strong statement about the importance of NIH on @cbsnews.com.web.brid.gy Sunday Morning (Part 1)
"Protein may be hot, but it’s fiber that Americans need to eat a lot more of." "To get the full health benefits of fiber, it’s important to eat a variety of naturally fiber-rich foods and not rely on supplements...could actually lead to health problems..." gift link www.wsj.com/health/welln...
Americans Don’t Eat Enough Fiber. Here’s Why That Worries Nutrition Experts
The latest science suggests our fiber-poor diets trigger inflammation and contribute to a range of related diseases.
wsj.com
![[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreid7lnvd7afmasx3nxi6anxmyhbatpaw54za3kiw3eaoclrf722faq)
