Job Alert: I'm looking for an enthusiastic research assistant to join my team at the Cambridge Stem Cell Institute. 🔗 Apply here: www.cam.ac.uk/jobs/biomedi... Applications close August 10. Please consider sharing to help spread the word.
Matt Towers
@matt-towers.bsky.social
Vertebrate limb development and evolution at the University of Sheffield https://towerslab.weebly.com/
Check out this new work from the Towers lab to learn how avian digit patterns can be transformed into mammalian-like patterns! 🔬🐣🧪 @matt-towers.bsky.social Video: www.youtube.com/watch?v=fvL_... Preprint: www.biorxiv.org/content/10.6...
Transforming Avian to Mammalian Modes of Digit Patterning
YouTube video by Matteo de la Torre
youtube.com
Five toed chicken anyone? Nice work from @matt-towers.bsky.social & co on reconstructing the evolutionary pathway to digit loss in birds
Pleased to share our latest! We show that the chick limb can be directed to recapitulate key stages in mammalian evolution, providing a unifying model for digit patterning across amniotes. Preprint: www.biorxiv.org/content/10.6... Video summary: www.youtube.com/watch?v=fvL_...
Pleased to share our latest! We show that the chick limb can be directed to recapitulate key stages in mammalian evolution, providing a unifying model for digit patterning across amniotes. Preprint: www.biorxiv.org/content/10.6... Video summary: www.youtube.com/watch?v=fvL_...
Transforming avian to mammalian modes of digit patterning
How a conserved embryonic organiser-the Sonic hedgehog (Shh)-expressing Zone of Polarising Activity (ZPA)-generates diverse limb architectures in amniotes remains a central problem in evolutionary and...
biorxiv.org
Our excursion into the world of hPSC-derived lateral plate mesoderm progenitors, the result of a great collaboration with the lab of @matt-towers.bsky.social. For more details check the thread of @sudeuyulgan.bsky.social below-Sude has been fantastic in leading and driving this work!
How do you build the posterior end of a body? 🧫🔬🧬 I am excited to share that my PhD work on the generation of hindlimb and genital progenitors from human pluripotent stem cells is now available on BioRxiv! 🔗 www.biorxiv.org/content/10.6...
Brilliant work, Sude—fascinating data and an impressive effort driving this project forward. Congrats!
How do you build the posterior end of a body? 🧫🔬🧬 I am excited to share that my PhD work on the generation of hindlimb and genital progenitors from human pluripotent stem cells is now available on BioRxiv! 🔗 www.biorxiv.org/content/10.6...
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
science.org
With the scientific input and experimental brilliance of the @franzelab.bsky.social this work was made possible. www.science.org/doi/10.1126/...
Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration
Tissue regeneration is rare in mammals, but the digit tip can regrow after amputation, whereas injuries beyond the nail do not. How the microenvironment drives divergent outcomes remains unclear. In this study, we found that the extracellular matrix (ECM)...
science.org
Our bat–mouse limb paper is now on bioRxiv! 🦇https://www.biorxiv.org/content/10.64898/2026.04.07.717074v2 This was a collaborative effort across the @nadavahituv.bsky.social Nicola Illing, Dorit Hockman, Guy Kelman, Tommy Kaplan labs and my lab at @washugenetics.bsky.social
Out now in @cp-iscience.bsky.social: we investigate how the peripheral limb architecture can affect the cellular and transcriptional maturation dynamics of spinal cord neurons #plasticity www.cell.com/iscience/ful... congrats and thanks to all co-authors!!! 👏🥳🙏
Transcriptional and cellular maturation of the chick spinal cord in the context of distinct neuromuscular circuits
Molecular biology; Neuroscience; Developmental biology; Omics
cell.com
PDRA position still open in my lab for anyone who wants to solve some outstanding questions in limb development. We have a variety of models and approaches (everything from stem cells to chicks and catsharks). Please share!
A BBSRC-funded PDRA position is available in my lab investigating vertebrate limb development! Please contact me for more details. www.jobs.ac.uk/job/DQH553/r....
A BBSRC-funded PDRA position is available in my lab investigating vertebrate limb development! Please contact me for more details. www.jobs.ac.uk/job/DQH553/r....
Research Associate in Developmental Biology at University of Sheffield
An opportunity for an academic position as a Research Associate in Developmental Biology is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
jobs.ac.uk
It's been quite a year for hypothalamic development. With this heroic analysis of developmental cell lineage, coupled with earlier multimode-based gene regulatory network analysis, the prosomere model looks like it has passed into history. www.nature.com/articles/s41...
Resolving forebrain developmental organisation by analysis of differential growth patterns - Nature Communications
Experiments on the embryonic chick brain reveal distinct directional growth patterns and a tripartite hypothalamus, challenging the classic segmented prosomere model and offering an updated view of ho...
nature.com
Excited to share a fantastic PhD opportunity combining interdisciplinary approaches with me, @alexgfletcher.bsky.social and @rorylcooper.bsky.social sky.social! Please share!
Bluesky
xgfletcher.bsky.social
🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬 This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share! www.findaphd.com/phds/project... 🧪
🚨 PhD Projects 🚨 We are advertising two UKRI funded PhD projects at the @sheffielduni.bsky.social. #stemcells #development #embryology #reproductivephysiology #mathmaticalmodelling #quantitativebiology
I'm a bit late to the party over here. I'll be advertising a BBSRC-funded postdoc position soon. So if anyone wants to solve some outstanding questions in limb development - please get in touch. We have a variety of models and approaches (everything from stem cells to sharks). towerslab.weebly.com