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Matt Towers

@matt-towers.bsky.social

Vertebrate limb development and evolution at the University of Sheffield https://towerslab.weebly.com/

8 Posts59 Follower61 Folgt
Meng Zhu@zhumeng123.bsky.social · 3d ago

Two years since the 1st submission, our work on limb heterochrony is finally out! 🎉🎊 @cellcellpress.bsky.social Delayed hindlimb dev vs forelimb is a widely conserved trait in mammals. We show that maternal O2 regulates this phenotype 👉🏻 shorturl.at/MGrwl

Shifts in embryonic oxygen levels cue heterochrony in limb initiation

Mammalian embryos see a substantial increase in available oxygen once the placenta forms. This increase in oxygen exposure serves as a trigger for initiating the development of the hindlimb, thus cont...

shorturl.at

James Briscoe@jamesbriscoe.bsky.social · 3mo ago

Five toed chicken anyone? Nice work from @matt-towers.bsky.social & co on reconstructing the evolutionary pathway to digit loss in birds

Matt Towers@matt-towers.bsky.social · 3mo ago

Pleased to share our latest! We show that the chick limb can be directed to recapitulate key stages in mammalian evolution, providing a unifying model for digit patterning across amniotes. Preprint: www.biorxiv.org/content/10.6... Video summary: www.youtube.com/watch?v=fvL_...

Matt Towers@matt-towers.bsky.social · 3mo ago

Pleased to share our latest! We show that the chick limb can be directed to recapitulate key stages in mammalian evolution, providing a unifying model for digit patterning across amniotes. Preprint: www.biorxiv.org/content/10.6... Video summary: www.youtube.com/watch?v=fvL_...

Transforming avian to mammalian modes of digit patterning

How a conserved embryonic organiser-the Sonic hedgehog (Shh)-expressing Zone of Polarising Activity (ZPA)-generates diverse limb architectures in amniotes remains a central problem in evolutionary and...

biorxiv.org

Anestis Tsakiridis@tsakiridis.bsky.social · 5mo ago

Our excursion into the world of hPSC-derived lateral plate mesoderm progenitors, the result of a great collaboration with the lab of @matt-towers.bsky.social. For more details check the thread of @sudeuyulgan.bsky.social below-Sude has been fantastic in leading and driving this work!

Sude Uyulgan@sudeuyulgan.bsky.social · 5mo ago

How do you build the posterior end of a body? 🧫🔬🧬 I am excited to share that my PhD work on the generation of hindlimb and genital progenitors from human pluripotent stem cells is now available on BioRxiv! 🔗 www.biorxiv.org/content/10.6...

@canaztekin.bsky.social · 6mo ago

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo

Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration

Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...

science.org

Mekayla Storer@storerlab.bsky.social · 6mo ago

With the scientific input and experimental brilliance of the @franzelab.bsky.social this work was made possible. www.science.org/doi/10.1126/...

Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration

Tissue regeneration is rare in mammals, but the digit tip can regrow after amputation, whereas injuries beyond the nail do not. How the microenvironment drives divergent outcomes remains unclear. In this study, we found that the extracellular matrix (ECM)...

science.org

Tschopp Lab@tschopplab.bsky.social · 6mo ago

Out now in @cp-iscience.bsky.social: we investigate how the peripheral limb architecture can affect the cellular and transcriptional maturation dynamics of spinal cord neurons #plasticity www.cell.com/iscience/ful... congrats and thanks to all co-authors!!! 👏🥳🙏

Transcriptional and cellular maturation of the chick spinal cord in the context of distinct neuromuscular circuits

Molecular biology; Neuroscience; Developmental biology; Omics

cell.com

Seth Blackshaw@sethblackshaw.bsky.social · 9mo ago

It's been quite a year for hypothalamic development. With this heroic analysis of developmental cell lineage, coupled with earlier multimode-based gene regulatory network analysis, the prosomere model looks like it has passed into history. www.nature.com/articles/s41...

Resolving forebrain developmental organisation by analysis of differential growth patterns - Nature Communications

Experiments on the embryonic chick brain reveal distinct directional growth patterns and a tripartite hypothalamus, challenging the classic segmented prosomere model and offering an updated view of ho...

nature.com

Matt Towers@matt-towers.bsky.social · 11mo ago

Excited to share a fantastic PhD opportunity combining interdisciplinary approaches with me, @alexgfletcher.bsky.social and @rorylcooper.bsky.social sky.social! Please share!

Bluesky

xgfletcher.bsky.social

Rory Cooper@rorylcooper.bsky.social · 11mo ago

🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬 This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share! www.findaphd.com/phds/project... 🧪

Matt Towers@matt-towers.bsky.social · last yr.

I'm a bit late to the party over here. I'll be advertising a BBSRC-funded postdoc position soon. So if anyone wants to solve some outstanding questions in limb development - please get in touch. We have a variety of models and approaches (everything from stem cells to sharks). towerslab.weebly.com