Altegoerlab
@faltegoer.bsky.social
PI at Düsseldorf University| Exploring Fungal Communication with a focus on GPCRs | Passionate about Structural Biology | altegoerlab.de
Our paper on the subcellular proteome of Paulinella is finally out! A possible oxygen-scavenging mechanism to enhance RuBisCO carboxylation highlights how protists can reveal unexpected solutions to challenges in photosynthesis. Big kudos to everyone involved! @evanowack.bsky.social
Ben Long@botbml.bsky.social · 13h agoSpatial proteomics reveals carboxysome adaptation and mitochondrial proteome in Paulinella chromatophora www.cell.com/current-biol...
Very excited that our discovery of Sms1 as the #MAPK #scaffold of fission yeast mating has just been published in @natcomms.nature.com! @biology-unige.bsky.social www.nature.com/articles/s41...
Happy to share that our study of the interaction between the MAX effector AVR-Pia and rice HMA domain-containing proteins has been published (as the cover article!) in PLOS Pathogens. journals.plos.org/plospathogen...
Two folds, many faces: The Magnaporthe oryzae MAX effector AVR-Pia targets novel rice HMA domain-containing proteins
Author summary Blast, caused by the fungal pathogen Magnaporthe oryzae, is one of the world’s most devastating rice diseases. During infection, M. oryzae secretes a diverse set of molecules, known as ...
journals.plos.org
Another step in the #Starship story - they move via a circular intermediate. Helps explain how these elements horizontally transfer and means that we can modify them into transformation vectors (starmids). www.biorxiv.org/content/10.6...
AlphaFold Database is expanding into pandemic preparedness. Together with NVIDIA, DeepMind, EBI et al. we exhaustively predicted ~1.7 million homo- & heterodimers across 2,812 viral proteomes, resulting in 8,028 high-confidence predictions. 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk
🗓️ Save the date! Next Wednesday at 16:00 CEST, the ERGA BioGenome Analysis & Applications Seminars are back with a talk on Starship transposons and their implications for fungal evolution 🍄 Speakers: @mycomile.bsky.social & @fungage-lab.bsky.social 🔗 www.erga-biodiversity.eu/post/starshi...
Starship transposons and a new framework to understand fungal evolution
This month's ERGA BioGenome Analysis & Applications Seminar will feature talks by Emile Gluck-Thaler and Aaron Vogan on the recently discovered Starship giant transposons and their implications for…
erga-biodiversity.eu
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
Proudly present our fantastic collaborative effort within SFB 1535 "Microbial networking" @mibinet.bsky.social now out in The ISME Journal. "Context-dependent siderophore exploitability shapes microbial community structure" academic.oup.com/ismej/advanc... @hhu.de @fz-juelich.de @dfg.de
www.biorxiv.org/content/10.6...
Cellular integration of surface and nutrient signals during the early stage of filamentous growth in Saccharomyces cerevisiae
Budding yeast cells can transition from vegetative to filamentous growth under specific environmental stimuli. Saccharomyces cerevisiae has served as a model to understand this process, which is linke...
biorxiv.org
BFVD v3 contains 5.8M viral protein structures, 16× more than v2; 75% high quality, filling a major gap in AFDB coverage. It fully covers 72.6% of reference proteomes and spans 72.7% of ICTV species. Great work by @eunbelivable.bsky.social et al. 📄 www.biorxiv.org/content/10.6... 🌐 bfvd.foldseek.com
#InternationalMicroorganismDay is a great time to share a work just published in ISME Journal; a massive collaborative network at Forschungszentrum Jülich and Heinrich Heine University Düsseldorf by @frunzkelab.bsky.social and colleagues #Community & #siderophores academic.oup.com/ismej/advanc...
Come be our colleague at @hhu.de @chemiehhu.bsky.social ! We are currently looking for 2 Full Professors in Physical chemistry in our department! berufungsportal.hhu.de/VAADIN/dynam... berufungsportal.hhu.de/VAADIN/dynam... #chemsky #chemchat 🧪
berufungsportal.hhu.de
Poster prizes at #EMBOBacNet congratulations to all! 👏 More than 100 posters with exciting research!
ColabFold 1.6.3 is out! 2.5x faster, pip-installable, ipSAE+pDockQ2 scores. Thanks Choonghwan Lee, Marielle Russo, Gyuri Kim 🐍pip install colabfold[alphafold] CF2 Sneak Peak with AF3/Boltz/Protenix/ESMFold2… 🐍pip install "colabfold[alphafold3]@git+https://github.com/sokrypton/ColabFold@af3-preview"
www.nature.com/articles/s41...
Cryo-EM structures of Candida albicans chitin synthase Chs1 reveal a druggable translocation channel - Nature Microbiology
Structures of Candida albicans class II chitin synthase reveal mechanisms of oligosaccharide translocation and inhibition. The translocation channel is a class II-specific druggable site, and its inhi...
nature.com
🍄🟫💻 Explore UKCEH’s new Fungi Explorer, an interactive tool revealing the hidden world of soil fungi across Great Britain using DNA data from 1,000+ Countryside Survey soil samples. Search species, map distributions, or match your own DNA sequences. https://connect-apps.ceh.ac.uk/fungal-explorer/
Excited to share this pre-print from my PhD work! We explore a Pmk1-Mst12-Bip1 network required for appressorium-mediated infection by the blast fungus 🌾 www.biorxiv.org/content/10.6... Thread 👇
A Pmk1-Regulated Mst12-Bip1 Network Coordinates Appressorium Function, Effector Deployment, and Invasive Growth by Magnaporthe oryzae
To cause rice blast disease, the filamentous fungus Magnaporthe oryzae develops a specialised infection cell called an appressorium, which generates enormous turgor to breach the rice leaf cuticle. Al...
biorxiv.org
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
Latest preprint from our group. We found the Bip1 transcription factor is phosphorylated in a Pmk1-dependent manner & with Mst12 co-regulates appressorium-specific functions, as well as acting on genes associated with invasive growth. @camilla-moli.bsky.social www.biorxiv.org/content/10.6...
A Pmk1-Regulated Mst12-Bip1 Network Coordinates Appressorium Function, Effector Deployment, and Invasive Growth by Magnaporthe oryzae
To cause rice blast disease, the filamentous fungus Magnaporthe oryzae develops a specialised infection cell called an appressorium, which generates enormous turgor to breach the rice leaf cuticle. Al...
biorxiv.org
Fold Spacer lets you fly through protein structures (Weekend project #2). It’s my first game: I originally set out to build a racer with structures as the tracks, but was a little too crazy. So it became this instead. You can upload your own structures. 🌐 martin-steinegger.github.io/Fold-Spacer/
How does linear motifs drive dephosphorylation - and does it matter where and how strong the motifs are? These are the question Evi answers in her brand new pre-print: www.biorxiv.org/content/10.6...
Happy to share our new preprint on the structure of the human mitochondrial RNA degradosome, a central player in organellar RNA metabolism! Work led by graduate student @paulafprado.bsky.social in our group. www.biorxiv.org/content/10.6... 🧵 1/9
📣...and now for something completely different: no plant pathogens, no Verticillium, but lichens! Driven by our lichen king🤴@ciarankelly.bsky.social with help of a.o. @hroevenich.bsky.social @usadellab.bsky.social @vivienrosenthal.bsky.social Watch for more in future! www.biorxiv.org/content/10.6...
Decoupled evolution of antimicrobial repertoires in lichen-forming fungi
Lichens are stable multipartite symbioses in which a fungal mycobiont associates with one or more photosynthetic partners while hosting complex microbiomes. Secreted antimicrobial proteins (AMPs) have...
biorxiv.org
Ciaran Kelly@ciarankelly.bsky.social · 3w agoOur new preprint is out! 🍄 Decoupled evolution of antimicrobial repertoires in lichen-forming fungi We compared many lichen-forming fungal genomes to ask how different photobiont associations relate to their antimicrobial repertoires.
Our new preprint is out! 🍄 Decoupled evolution of antimicrobial repertoires in lichen-forming fungi We compared many lichen-forming fungal genomes to ask how different photobiont associations relate to their antimicrobial repertoires.
A new preprint from the lab! 📄 We solved a long-standing question: how mechanistically the PTM AMPylation of glutamine synthetase controls the activity of one of the most important enzymes on Earth. 🌎 w/ beautiful cryoEM structures @hhu.de & @sfb1381.bsky.social www.biorxiv.org/content/10.6...
Metabolic regulation and structural mechanism of glutamine synthetase AMPylation
In bacteria, glutamine synthetase (GS) is the main ammonium assimilation enzyme. Its activity is tightly regulated according to cellular energy status and carbon/nitrogen balance through reversible AM...
biorxiv.org
AlphaFold Server’s ligand menu just got a lot bigger and I almost missed it! You can now add any ligand from the wwPDB Chemical Component Dictionary. Just enter its CCD code 🥳
Our lab is looking for PhD students to join us in 2027 🎓🎉 The projects can be structured around our research directions: - Transposable element dynamics - Fungal pangenomics - ML/language model genomics applications - Pathogen adaptation More here pathogen-genomics.org ("Jobs") and please share! 🙏
Evolutionary genomics of pathogens
Croll lab at University of Neuchatel. The lab of Daniel Croll wants to understand how pathogens evolve to cause disease. For this, we mainly focus on major crop pathogens to unravel mechanisms of rapi...
pathogen-genomics.org
🦠 Die Leopoldina ehrt Mikrobiologin Regine Kahmann für ihr Lebenswerk mit der Cothenius-Medaille. Herzlichen Glückwunsch! ✨
