A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

I know it seems like a heretical idea, but one way to figure out if a preprint is really interesting (to you) is... to read the preprint. Then, in the spirit of sharing, send a note to authors: a simple kudos or a more detailed question. I do this a dozen times a year. It's awesome. Try it.

🚨 Abstract submission deadline is approaching for #EMBOEvoEco! If you want to be part of the EMBO Workshop focusing on uncovering the mechanistic foundations of ecological and evolutionary processes. Submit your abstract by 30 June: https://s.embl.org/eae26-01-bl

Researchers selected yeast cells for small size for 1,500 generations, achieving a fourfold modal volume reduction, and identified mutations in nutrient-sensing and cell-cycle pathways that enabled shrinkage while maintaining relatively high fitness. In PNAS: https://ow.ly/zezn50ZcU0y

Our paper on the evolution of cellular miniaturization is now out in PNAS! www.pnas.org/doi/10.1073/... A short recap 🧵

Marco Fumasoni@marcofumasoni.bsky.social · 9mo ago

🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥 www.biorxiv.org/content/10.6...

A few snapshots from the @embo.org workshop “The Rules of the Game: biophysical and molecular principles in cellular evolution” — and an excuse to thank everyone who made it such a fun, stimulating, and inspiring few days at @gimminstitute.bsky.social #EMBORulesOfTheGame

How do we fund and publish research that doesn't fit neatly into a single discipline? Last week, at the #EMBORulesOfTheGame, #HFSP Chief Scientific Officer Guntram Bauer presented how HFSP supports #frontierscience across disciplines and borders. @embo.org

New SPCG preprint in collaboration with the Amir lab We solve an accumulator model of cell division with noisy threshold and memory, finding a continuum of strategies from timer to adder to sizer and that extrinsic noise is essential to explain E. coli size fluctuations. arxiv.org/abs/2605.070...

The final program for the EMBO Workshop “The rules of the game: biophysical & molecular principles in cellular evolution” is online! A few seats are still available if you want to attend (Deadline May 15th) @embo.org @gimminstitute.bsky.social meetings.embo.org/event/26-cel...

What a nice summary of our preprint on cellular miniaturization! Thank you @anastasiamoraiti.bsky.social for writing this wonderful @prelights.bsky.social!

preLights@prelights.bsky.social · 4mo ago

The incredible shrinking cells: a guide to efficient downsizing @anastasiamoraiti.bsky.social highlights research from Ana Garoña & @marcofumasoni.bsky.social uncovering a putative mechanism for cell size evolution. #preprint #evolution #cellbio #preLight⤵️: prelights.biologists.com/highlights/e...

FumaLab milestone unlocked this week: first PhD graduate 🎓 Congrats Dr. (and resident sous chef!) @mariananatalin6.bsky.social!!! — proud and lucky PI.

Some of us know how sweet procrastination can be! If you feel the same, good news: The abstract deadline for the EMBO Workshop has been extended to March 19! Don’t miss the opportunity to present your work June 2–5 2026 in Oeiras, Portugal!

Marco Fumasoni@marcofumasoni.bsky.social · 9mo ago

📢 Join us in sunny Lisbon 🇵🇹 2-5 June for the @embo.org workshop ☀️ “The rules of the game: biophysical & molecular principles in cellular evolution” Apply by March 1st! Please repost to help spread the word! meetings.embo.org/event/26-cel... #EMBORulesOfTheGame @gimmfoundation.bsky.social

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)

Nature Portfolio@natureportfolio.nature.com · 7mo ago

A study in Nature shows that the single-celled form of a tiny, aquatic organism can turn into a multicellular version by three different routes. The discovery adds insight to the possible origins of multicellular life, suggesting a previously unrecognized degree of flexibility. 🧪

EMBO was part of the group that developed DORA's new introductory course on #ResponsibleResearchAssessment. 🧪 We’re pleased to see its launch, more info here: https://sfdora.org/2026/02/23/new-introductory-course/

Fostering Responsible Research Assessment: DORA Launches New Introductory Course | DORA

DORA is delighted to announce the launch of its Introduction to Responsible Research Assessment (RRA) Course. This online, self-paced course provides an approachable, entry-level curriculum for anyone at any career stage and in a variety of roles to learn about RRA. While the course is free for individuals to take, it requires registration, and provides the option of issuing a certificate for each of its four lessons and one for its full completion.

sfdora.org

GIMM Fest returns September 17–19 with three days dedicated to the future of science and health, this year focusing on microbes. 🦠 Join researchers and innovators for a programme designed to promote scientific exchange and collaboration.

🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇 www.biorxiv.org/content/10.6...

Now with the final graphic ✨ Beautiful artwork by Sonia Monti (scientific-visualization-solutions.com). Design by @embo.org 🧬 The Rules of the Game 📍 @gimmfoundation.bsky.social, Oeiras (PT) | June 2–5, 2026 🗓️ Register by March 1st 👉 meetings.embo.org/event/26-cel...

Join the dialogue on the #evolution of cellular processes at the EMBO Workshop "The rules of the game: Biophysical & molecular principles in cellular evolution" in #Oeiras, PT, 2–5 June 2026. Deadline: 1 March https://meetings.embo.org/event/26-cellular-evolution #EMBORulesOfTheGame #EMBOevents 🧪

📢 Join us in sunny Lisbon 🇵🇹 2-5 June for the @embo.org workshop ☀️ “The rules of the game: biophysical & molecular principles in cellular evolution” Apply by March 1st! Please repost to help spread the word! meetings.embo.org/event/26-cel... #EMBORulesOfTheGame @gimmfoundation.bsky.social

🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥 www.biorxiv.org/content/10.6...

So proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍 The mighty yeast reveals what we believe are general principles of centromere evolution! Behind the curtain: communities.springernature.com/posts/counti... #MEvoSky 🧪🌎

Counting Chromosomes: The Simple Idea That Unlocked the Rules Behind Centromere Evolution

communities.springernature.com

Jana Helsen@helsenjana.bsky.social · 10mo ago

How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1

How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1

Now published on @plos.org Computational Biology! Same findings as the preprint, with improved analyses suggested by reviewers! Check it out and let us know how RepliFlow works for you! journals.plos.org/ploscompbiol...

Model-based inference of cell cycle dynamics captures alterations of the DNA replication programme

Author summary The cell cycle is the coordinated sequence of events between two consecutive cell divisions. In eukaryotes, the cell cycle consists of four main phases: G1, S, G2, and mitosis. Understa...

journals.plos.org

Marco Fumasoni@marcofumasoni.bsky.social · last yr.

🗞️New preprint out! Together with Adolfo Alsina and Pablo Sartori (both not on here), we combined experiments and theory to extract detailed information on DNA replication dynamics from simple DNA content flow cytometry data. www.biorxiv.org/content/10.1...

I'm curious if other mid career PIs have considered completely abandoning the trad publication model. We've been making gradual moves towards that end goal. But it's been difficult to completely jump ship for one main reason for me at least. 1/

I’m super happy to present the first discoveries of the RIKEN-Cambridge Joint Crop Symbiosis Research Team, based in Japan 🇯🇵 doi.org/10.1101/2025... A thread 👇

Reductive evolution of the DNA replication machinery in endosymbiotic fungi

The molecular machinery for replicating and repairing DNA accurately is critically important for life and highly conserved across the Tree of Life. Here we show that two major lineages of fungi, Glome...

doi.org

how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)

Melania D'Angiolo@melaniadangiolo.bsky.social · last yr.

Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response. www.biorxiv.org/content/10.1...

@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....

📢 New paper out in Mol Syst Biol! During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬 🔗 www.embopress.org/doi/full/10....

Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response. www.biorxiv.org/content/10.1...

The adaptive molecular landscape of reprogrammed telomeric sequences

Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequen...

biorxiv.org

Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute. www.crg.eu/en/news/moni...