Miniscope Zero, the first fully wireless Miniscope, is on @biorxivpreprint.bsky.social! Wireless power + data enable neural recordings in enclosed mazes, 3D environments & from two animals at once! @miniscope.bsky.social Paper: doi.org/10.64898/202... Wiki: miniscope.org/wiki/Minisco...

Most cortical neurons exhibit mixed selectivity rather than specializing in a single function. Our limited ability to juggle tasks may therefore reflect interference among overlapping neural representations. www.nature.com/articles/s41... #neuroscience

Feature interference underlies a neuronal basis for the behavioral cost of task uncertainty - Nature Neuroscience

Using a combined approach of monkey electrophysiology, artificial neural networks and human psychophysics, Xue et al. show that neuronal interference from irrelevant information underlies behavioral e...

nature.com

This is such cool work, especially the idea that on-manifold geometry is "imposed by the circuit's intrinsic dynamics" and not just stim encoding. We think something similar happens in human hippocampus—though tbf we haven't characterized the stimulus encoding dims yet bsky.app/profile/jhen...

Eliezyer de Oliveira@eliezyer.bsky.social · 2d ago

After a long journey through review, our paper is finally out in Nature Communications. We started with a simple problem: The visual cortex is strongly modulated by movement. So how can it represent the visual world without movement interfering with everything? www.nature.com/articles/s41...

Now published in PLoS Computational Biology! A cortical model combining geometric wave propagation with connectome-wired fast-conducting non-local projections (which strongly shape rapid stimulus-evoked responses but contribute little to slower spontaneous fluctuations) doi.org/10.1371/jour...

Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics

Author summary Despite the complex wiring patterns found in the cortical connectome, many dynamical properties of macroscale cortical activity can be surprisingly well explained by treating the cortex...

doi.org

Ben Fulcher@bendfulcher.bsky.social · last yr.

New preprint! Why are long-range connectomic interactions in the cortex dominant in shaping dynamics in some experiments but apparently negligible in others? We (w/ R Maran, @elimuller.bsky.social) address this question by studying a new hybrid model of cortical dynamics. arxiv.org/abs/2506.19800

Approximating the Lorenz attractor with a chaotic leaky water wheel. The orange dot is the centre of mass of the water. It traces (a projection of) the familiar attractor as the wheel spins seemingly randomly left and right.

Representational learning by optimization of neural manifolds in an olfactory memory network www.nature.com/articles/s41...

Representational learning by optimization of neural manifolds in an olfactory memory network - Nature Neuroscience

Using experiments and theory, the authors examine how olfactory memories are encoded in the zebrafish olfactory cortex. They find that experience reshapes the internal map of odor space, making releva...

nature.com

📢Have work to share with the computational and systems neuroscience community? Abstract submissions for #COSYNE2027 are now open. Deadline: 18 October 2026, 11:59 p.m. AoE Submit your abstract: www.cosyne.org/abstracts-su... #Neuroscience

NeurIPS is approaching and registration for the Paris site will be opened on Monday Sept 14th, Anywhere on Earth. Registration happens at neurips.cc, each of the 3 sites has its own registration process. We'll be happy to see you in Paris!

An acortical mouse — born without hippocampus and most of its neocortex — learns the Manhattan Maze: a 30× improvement in 5 hours, 18 rewards! Now a question for everyone: How can an acortical brain do this? Leave a comment! Preprint w/ @mameister4.bsky.social: www.biorxiv.org/content/10.6...

Here is the full clip of an embryonic myeloid cell transiting from inside to outside of an explant. It's one of my most favorite clips. Note how the nucleus 🔵 is squeezed right at the tissue boundary, and the myosin signal 🔴 goes from rearward to randomly distributed. How cool? #FluorescenceFriday

But overall the main point is about the power of the manifold. Some people have been pushing this, for example, here’s a fantastic review arguing that place cells dont really remap as we've been taught - they just project differently depending on context. www.nature.com/articles/s41...

Remapping revisited: how the hippocampus represents different spaces - Nature Reviews Neuroscience

The location-specific firing of hippocampal place cells changes when an animal enters a new environment, a phenomenon known as ‘remapping’. In this Perspective, André A. Fenton challenges standard mod...

nature.com

Neural activity is often summarized as a small number of shared patterns (low-dimensional structure). sliceTCA offers a more complete and efficient way to uncover meaningful structure in large-scale brain recordings. www.nature.com/articles/s41... #neuroscience

Dimensionality reduction beyond neural subspaces with slice tensor component analysis - Nature Neuroscience

Neural activity does not always lie in a low-dimensional subspace. The authors extend this classic view to show that task-relevant information is distributed across multiple covariability classes and ...

nature.com

Our latest paper is now online at Advanced Science. Li et al, Early spatial and contextual coding deficits in hippocampal CA1 precede performance decline in an Alzheimer’s disease model. advanced.onlinelibrary.wiley.com/doi/10.1002/...

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Two-photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task-related place cell activity and splitter cell trajectory coding are impaired, with ....

advanced.onlinelibrary.wiley.com

Very exciting theoretical work from Soledad Ganzalo Cogno´s new theory group. Will unquestionably guide my own future work. Congratulations, Soledad and team!

Soledad Gonzalo Cogno@soledad-gcogno.bsky.social · 7d ago

📢🔥🎉🤩 New preprint from the lab, in collaboration with @clopathlab.bsky.social ! What network mechanisms generate a diversity of neural activity sequences within and across circuits? www.biorxiv.org/content/10.6... 🧵👇

New paper! Decision-making isn't just picking winners via more neural firing, the brain reorganizing activity patterns into different subspaces, shifting from "one option vs. another" to "chosen vs. rejected" doi.org/10.1016/j.is... #neuroscience @picowerinstitute.bsky.social @mitbcs.bsky.social

Subspaces may be formed and organized via brain waves. "Low-dimensional spiking trajectories in subspace can be seen as the spiking-level expression of broader wave-based control signals that impose global structure on neural activity" doi.org/10.1523/JNEU...

Analog Cognition and Consciousness

Cognition and consciousness may arise from bidirectional interactions between neuronal spiking and rhythmic electric field activity (brain waves). Goal-directed behavior relies on top-down control to ...

doi.org

An animal’s body is in constant conversation with itself — & HHMI Janelia scientists have built a way to listen in. WHOLISTIC simultaneously records real-time activity from nearly every cell in a living larval zebrafish, a 1st step in understanding more complex bodies like ours: bit.ly/4xMR1Ww.

#Human #cortical #networks trade #communication efficiency for #computational reliability | Science Advances www.science.org/doi/10.1126/...

Human cortical networks trade communication efficiency for computational reliability

Brains are often described as cost-efficient communication networks that optimally balance long-connection costs against fast communication. Inspired by the “use it or lose it” principle, we present a...

science.org

Terence Tao says AI companies are harming mathematics by dropping new results without engaging with academia. “These companies are dumping carcasses of raw meat onto our table and saying ‘here you go, I solved your food problem’ and then they just leave." www.newscientist.com/article/2588...

Terence Tao: AI companies are harming mathematics | New Scientist

AI companies are making new mathematical discoveries at a rapid pace but not sticking around to help unpick the new proofs. That is not the way to advance our understanding, says mathematician Terence...

newscientist.com

New paper from the Neurosurgery Research Team at BCM! “Neural geometry in the human hippocampus enables generalization across spatial position and gaze” led by @assiachericoni.bsky.social! 🧵 www.cell.com/neuron/abstr...

Neural geometry in the human hippocampus enables generalization across spatial position and gaze

Chericoni et al. show that neurons in the human hippocampus track the positions of multiple agents in a simple pursuit-based video game. They identified place codes for each agent and for gaze. The co...

cell.com

📢🔥🎉🤩 New preprint from the lab, in collaboration with @clopathlab.bsky.social ! What network mechanisms generate a diversity of neural activity sequences within and across circuits? www.biorxiv.org/content/10.6... 🧵👇

A common structure in recurrent networks supports neural sequence generation locally and in downstream neurons

Neural sequences, characterized by neurons or groups of neurons that fire one after the other, have been observed in multiple brain regions, across species, and are known to underlie a diversity of br...

biorxiv.org

We're excited about opportunities to track non-stationary variation in real-world systems, in extending beyond the many current analyses that assume stationarity. Preprint again: arxiv.org/abs/2609.01651

Parameter inference from a non-stationary unknown process using statistical feature-based slow feature analysis

Non-stationary phenomena are ubiquitous, with examples to be found in climatological measurements, brain activity, and the behavior of financial markets. Starting with a time series from a non-station...

arxiv.org

Our group discovered that reasoning models produce fractals when asked to solve hard problems. We can use nonlinear dynamics to probe the thinking processes of recurrent depth models on Sudoku, mathematics, and even ARC-AGI (1/N) arxiv.org/abs/2609.04963

This was a fun one to write! Check it out if you want my (not-so-spicy) take on the recurring discussions about dimensionality in neural activity.

The Transmitter @thetransmitter.bsky.social · last wk.

I fear that placing too much emphasis on a specific interpretation of dimensionality, or treating dimensionality as an end-all quantification of some aspect of neural computation, may lead us down the wrong path, writes @mattperich.bsky.social. #neuroskyence www.thetransmitter.org/neural-dynam...

When fruit flies catch a whiff of apple cider vinegar, they zigzag along the edge of the odor plume rather than traveling through the middle, new work shows. #neuroskyence By @callimcflurry.bsky.social www.thetransmitter.org/olfaction/fr...

Fruit flies use memory to track odors

When flies encounter a tasty smell, they stroll in and out of the odor plume to keep track of it, encoding a memory of the angle they need to travel.

thetransmitter.org

New preprint by @shtakasu.bsky.social , Gast & @antihebbiann.bsky.social, showing that local exc/inh connectivity balance can strongly reshape #RecurrentNetwork dynamics, even when the connectivity spectrum remains unchanged. #CompNeuro #TheoreticalNeuroscience #RandomNetworks #PopulationDynamics

Ann Kennedy@antihebbiann.bsky.social · last wk.

New preprint on our favorite theme: same connectome + different neurons = different dynamics. @shtakasu.bsky.social looked at detail balance (E+I inputs sum to 0) in RNNs w/different activation functions, finding that it stabilized some networks and destabilized others. arxiv.org/html/2608.30...

How does the brain solve complex tasks on just 20W of power? 💡 In a new Q&A with the Sainsbury Wellcome Centre, Dr. Panayiota Poirazi explains how active dendrites & synaptic clustering allow neurons to maximize computational efficiency. Read the Q&A here: www.sainsburywellcome.org/qa/smarter-w...

Smarter wiring: How dendrites make neurons more efficient | Sainsbury Wellcome Centre

In this Q&A, SWC Seminar Speaker Dr Panayiota Poirazi, Research Director at IMBB, discusses her latest work on how dendrites facilitate efficiency in the brain.

sainsburywellcome.org

🐭🐒 Why do mouse and monkey brains respond differently to movement? A study co-authored by @jongant.bsky.social suggests they may follow the same basic principle of information processing – but process different visual inputs. Read the whole story 👉️ bit.ly/4gTo0kO #BernsteinNetwork #CompNeuro 🧠📈

Our task-switching paper is now out at Current Biology! www.cell.com/current-biol... We find that that our brains reset to a task-neutral state between trials, providing flexibility when the upcoming task is uncertain. RNNs also learn this strategy, but only when trained to switch tasks.

Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n