The most impt change at #NIH and to US science this year is bigger than grant cancellations— it’s how the agency is governed. For 75 years NIH has been largely independent of presidential control. That’s changed this year. New piece from me and @nataliebaviles.bsky.social in @nature.com 🧪

How Congress can restore the independence of US science

Members must go beyond reinstating US government research spending and re-establish decentralized governance at the National Institutes of Health and other agencies.

nature.com

#NatMetabPicks | In @cp-cell.bsky.social led by @lydiafinley.bsky.social ( @mskcancercenter.bsky.social ) 🧪 Citrate clearance is an essential function of the TCA cycle via the activity of aconitase 2. www.cell.com/cell/fulltex...

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

cell.com

One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

cell.com

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

Aspartate availability drives differential engagement of the malate-aspartate shuttle

Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate s...

cell.com

Over 600 New Yorkers attended our Virtual Town Hall today to advocate for state-based science funding! We were joined by researchers, patients, institutions, and elected officials. @amsnyc.bsky.social @nycures.bsky.social @uawregion9a.bsky.social

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

BREAKING: Scientists are staging a “science fair” in the lobby of a Congressional building to tell elected officials about the critical knowledge the US will lose because their research grants have been canceled.

A study from the #MarraffiniLab in @science.org shows that newly discovered weapons of bacterial self-defense take different approaches to achieving the same goal: preventing a virus from spreading through the bacterial population. Learn more: bit.ly/4dvmBij

🦠🧫 @science.org Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response | Science www.science.org/doi/10.1126/... @christianfbaca.bsky.social @rockefelleruniv.bsky.social @hhmi.org @mskcancercenter.bsky.social

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Intracellular metabolic gradients dictate dependence on exogenous pyruvate

Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

rdcu.be

✨🦟✨HOW DO MOSQUITOES HAVE SEX? ✨🦟✨ Join us for a wild journey into hidden female control, rapidly evolving stimulation devices, fierce species competition, and DEADLY MOSQUITOES! www.biorxiv.org/content/10.1...

I’m so excited for the start of the Aviram Lab!! Going to miss @naamaaviram.bsky.social in lab but at least she’s right across the street 🤞

Naama Aviram@naamaaviram.bsky.social · last yr.

Here we go! #newPI #WomenInSTEM @mskeducation.bsky.social @mskcancercenter.bsky.social

Thrilled that my thesis work in @lydiafinley.bsky.social's lab is out in the world! We found that methotrexate targets a specific metabolic vulnerability in a particularly aggressive form of pediatric rhabdomyosarcoma. Thank you to everyone who contributed to this project over the years!

bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 2y ago

PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma https://www.biorxiv.org/content/10.1101/2025.01.15.633227v1

Our latest preprint identifies (targetable!) metabolic programs intrinsic to different cancer cell states in rhabdomyosarcoma, out just in time for @katrinaparas.bsky.social's thesis defense tomorrow!

bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 2y ago

PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma https://www.biorxiv.org/content/10.1101/2025.01.15.633227v1

HUGE congratulations to @paigearnold.bsky.social for being named a @hhmi.bsky.social Hanna Gray Fellow! A well-deserved recognition for all of your accomplishments and promise: I can't wait to see what you do next!!

Paige Arnold@paigearnold.bsky.social · 2y ago

New to 🦋 but beyond thrilled to share that I’m joining the new cohort of @hhmi.bsky.social #HannaGrayFellows! 🎉 I’m so excited to connect with this incredible community of scientists. Many thanks to HHMI for this opportunity and my mentors @lydiafinley.bsky.social and Luciano Marraffini!

New to 🦋 but beyond thrilled to share that I’m joining the new cohort of @hhmi.bsky.social #HannaGrayFellows! 🎉 I’m so excited to connect with this incredible community of scientists. Many thanks to HHMI for this opportunity and my mentors @lydiafinley.bsky.social and Luciano Marraffini!

HHMI@hhmi-science.bsky.social · 2y ago

Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists!