Cross-organ immune circuit where viral pattern sensing in skin potently counteracts viral encephalitis during WNV or neurotropic arbovirus infection via systemic type I IFN signaling in brain endothelial cells www.cell.com/immunity/ful... @cp-immunity.bsky.social @rockefeller.edu

Could a cross-organ warning system be a defining factor in how the brain combats arthropod-borne neurotropic viruses?

Alexander Lercher of Rockefeller's Rice lab studies how fighting off one virus changes the way the immune system responds to a totally unrelated one. His work is uncovering immune pathways that let our bodies adapt to viral threats over time. 🔗: https://bit.ly/43GfYWw

Cell metabolism is not one-size-fits-all. New HFSP-supported research reveals how cells tune the TCA cycle and connected pathways depending on nutrient use, citrate levels, and aspartate demand. 🧪 Story 👉 zurl.co/fo2gY #sts

We are thrilled to announce the 2026 Zara Weinberg Leading Edge Fellows! 40 remarkable postdocs pursuing transformative research in biological/biomedical sciences. This is the 7th Leading Edge cohort and we are so excited to welcome them! www.leadingedgesymposium.org/fellows/

Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...

Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature

l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...

nature.com

Key roles for monocyte-derived cells in CNS metabolism and reveals the pleiotropic beneficial effects of arginine in neuroinflammation @natimmunol.nature.com @schabbauerlab.bsky.social @meduniwien.ac.at www.nature.com/articles/s41...

Thank you so much for highlighting our work- Truly spot on and a great title!

Eddie Rashan@edreesrashan.bsky.social · 3mo ago

Check out our Spotlight in Molecular Cell on @lydiafinley.bsky.social's lab recent work on Aconitase 2 and its protective role against impaired cell fitness and ISR activation due to mitochondrial citrate accumulation authors.elsevier.com/c/1n3Nn3vVUP...

#NatMetabPicks | In @cp-cell.bsky.social led by @lydiafinley.bsky.social ( @mskcancercenter.bsky.social ) 🧪 Citrate clearance is an essential function of the TCA cycle via the activity of aconitase 2. www.cell.com/cell/fulltex...

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

cell.com

The main function of the TCA cycle is to feed electrons into the respiratory chain. ..wait, what!? It also clears excess citrate, because otherwise you get severe kidney damage? Great example that textbooks aren’t always the full story by Abby, @juliabrunner.bsky.social and @lydiafinley.bsky.social

Julia S. Brunner@juliabrunner.bsky.social · 5mo ago

One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...

@cp-cell.bsky.social is on 🔥 with #immunemetabolism! Zheng &co show that excessive glycolysis-driven pyrivate cause pyruvylation of STAT1 preventing #interferon signaling 👉 doi.org/10.1016/j.ce... & Finley &co show that ACO2 clears citrate preventing integrated stress response & kidney degeneration👇

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

cell.com

Now online! Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.

dlvr.it

Julia’s paper identifying Aspartate as a determinant cell-state specific engagement of the Malate-Aspartate-Shuttle is now out @cp-molcell.bsky.social!

Julia S. Brunner@juliabrunner.bsky.social · 5mo ago

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

cell.com

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

Aspartate availability drives differential engagement of the malate-aspartate shuttle

Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate s...

cell.com

☕Yashinskie, Zhu et al show that #p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of #autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling. @lydiafinley.bsky.social bit.ly/4asbwO3

p53 increases phospholipid headgroup scavenging in senescence - Nature Cell Biology

Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal catabolism programmes and in...

bit.ly

Critical role for a high-plasticity cell state in lung cancer @nature.com @mskcancercenter.bsky.social www.nature.com/articles/s41...

Polyamine-dependent metabolic shielding regulates alternative splicing @nature.com @cicbiogune.bsky.social www.nature.com/articles/s41...

@natmetabolism.nature.com turns 7! From our first issue in 2019 to our latest in Dec 2025, many thanks to the #metabolism community for your trust, support, and for allowing us to showcase your exciting work. We hope to continue serving the community and publish on all things metabolism! 🧪

Metabolism: How pyruvate controls cell size 🔗 eLife Insight Articles delve into the real significance of the latest research. Read here: buff.ly/F3gMKka.

The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor. The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2. www.leadingedgesymposium.org/apply/

Auszeichnung exzellenter österreichischer Wissenschaftler:innen in den USA: 3 Forschende erhalten heuer #ASciNA Awards für während ihrer Forschungsaufenthalte entstandene Publikationen: Wir gratulieren Caroline Moosmüller, Alexander Lercher u. Gabriele Wadlig! 👏 #BMFWF www.fwf.ac.at/aktuelles/de...

Verleihung der ASciNA Awards 2025 an drei Forschende aus Österreich in Washington, D.C.

Caroline Moosmüller, Alexander Lercher und Gabriele Wadlig wurden für ihre exzellenten Publikationen mit den ASciNA Awards 2025 ausgezeichnet.

fwf.ac.at

Innate immune memory is wild 🧠 Alexander Lercher from Rockefeller dives into how cells remember past infections and prep for future ones. Type I interferon doing way more than just fighting viruses! Full interview: buff.ly/5TKEJ9o #CytokineSociety #ImmuneMemory #TypeIInterferon #CellsHaveMemoriesToo

Member Highlight: Alexander Lercher on Innate Immune Memory and Real-World Microbe Responses - Biweekly newsletter of the International Cytokine & Interferon Society

My name is Alexander Lercher, and I am currently a Postdoc in the lab of Charlie Rice at Rockefeller University in New York, and I am particularly excited about studying immune responses in the context...

signals.cytokinesociety.org

🚨 We're hiring! The Rendeiro Lab @cemm.oeaw.ac.at is looking for a data scientist or software engineer to work on open-source tools for spatial, histological & multimodal data. Ad: www.nature.com/naturecareer... More info: rendeiro.group

Data Scientist / Software Engineer in Computational Biology (f/m/d) - Vienna (Landbezirke) (AT) job with Research Center for Molecular Medicine (CeMM), ÖAW | 12842231

The Rendeiro lab at CeMM is recruiting a highly motivated data scientist to join our international team studying human aging and pathology.

nature.com

Extremely happy to be awarded the Sidney & Joan Pestka Post-graduate award! Thank you @cytokinesociety.bsky.social and all my mentors, colleagues and collaborators throughout my career so far!

International Cytokine & Interferon Society (ICIS)@cytokinesociety.bsky.social · last yr.

The International Cytokine & Interferon Society congratulates the winners of the 2025 Sidney & Joan Pestka Graduate and Post-Graduate Awards, the ICIS-Christina Fleischmann Award and the ICIS-Amanda Proudfoot Award. Read more at signals.cytokinesociety.org/2025/07/14/2...

Online now: The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury

The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury

Novak et al. discover that dietary serine impacts whether hair follicle stem cells (HFSCs) prioritize hair growth or skin repair after injury. HFSCs gauge metabolic stress using the ISR and accelerate re-epithelialization while delaying hair regeneration when serine-deprived. These findings suggest new metabolic and pharmacologic strategies to enhance wound repair.

dlvr.it

We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines. Learn more about these exceptional scientists: www.leadingedgesymposium.org/fellows

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Intracellular metabolic gradients dictate dependence on exogenous pyruvate

Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

rdcu.be

Postdoc Night Science NYC! Next session is Friday 4-6pm at MSK, to learn and practice the creative scientific process! The topic this time is the import/export of ideas. Yael David join us too! @davidlabmsk.bsky.social Limited spots: docs.google.com/forms/d/12bB... @kelseymonson.bsky.social

Postdoc Night Science NYC is coming to @mskcancercenter.bsky.social! #MSKPostdocs, come join Drs. @itaiyanai.bsky.social and @kelseymonson.bsky.social to explore and practice the creative scientific process. In this session, they will discuss how to import and export ideas across different fields.