Bacterial Hsp70 DnaK transiently samples the proteome to rapidly capture stress-induced misfolding.

Protein-quality-control systems are essential for cells to maintain protein homeostasis during both steady-state growth and acute stress. Yet, how individual chaperone molecules dynamically reorganize...

doi.org

Assistant professor in Living state physics | Aalto University

Aalto University is where science and art meet technology and business. We shape a sustainable future by making research breakthroughs in and across our disciplines, sparking the game changers of tomorrow and creating novel solutions to major global challenges. Our community is made up of 120 nationalities, 14 000 students, 400 professors and close to 5000 faculty and staff working on our dynamic campus in Espoo, Greater Helsinki, Finland. Diversity is part of who we are, and we actively work to ensure our community’s diversity and inclusiveness. This is why we warmly encourage qualified candidates from all backgrounds to join our community.

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Predictive biophysical neural network modeling of a compendium of in vivo transcription factor DNA binding profiles for Escherichia coli - Nature Communications

The authors describe BoltzNet, a neural network that learns the energy of transcription factor (TF)-DNA binding from genomic data and can be used to design new binding sites. They report the in vivo mapping and BoltzNet modeling of 139 E. coli TFs.

bit.ly

Phenotypic plasticity in cell elongation among closely related bacterial species

Nature Communications - Multiple types of cell elongation have been described in bacteria, but little is known about how these strategies vary across species. Here, the authors use fluorescent...

nature.com

A palette of bridged bicycle-strengthened fluorophores - Nature Methods

A suite of bridged rhodamine dyes (BriDyes) offers excellent brightness, solubility, photostability, and tunable cell permeability along with resistance to photoblueing, making them exceptional all-pu...

nature.com

Dynamics of bacterial operons during genome-wide stresses is influenced by premature terminations and internal promoters

Internal promoters in operons are critical in genome-wide stress responses, compensating for frequent premature RNAP falloffs.

science.org

The nucleoid of rapidly growing Escherichia coli localizes close to the inner membrane and is organized by transcription, translation, and cell geometry - Nature Communications

The mechanisms underlying bacterial chromosome configuration are not fully understood. Here, Spahn et al. show that the Escherichia coli nucleoid adopts a condensed, membrane-proximal configuration du...

nature.com

Robust and resource-optimal dynamic pattern formation of Min proteins in vivo

Nature Physics - Oscillatory Min protein patterns prevent abnormal bacterial cell division. Now it is shown that Min pattern formation is resource efficient and involves wavelength-invariant...

rdcu.be

Tissue-like multicellular development triggered by mechanical compression in archaea

The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...

science.org

Bright and photostable yellow fluorescent proteins for extended imaging - Nature Communications

Yellow fluorescent proteins (YFPs) photobleach rapidly, restricting microscopy experiments. Here, the authors report mGold2s and mGold2t, YFPs that extend imaging durations up to 25 times longer than ...

nature.com

Live tracking of replisomes reveals nutrient-dependent regulation of replication elongation rates in Caulobacter crescentus

Adhikashreni et al. use quantitative live-cell imaging to track cell-cycle dynamics in hundreds of individual bacteria. They observe nutrient-dependent regulation of replication elongation rates that ...

cell.com

Assistant Professor in Biophysics

wur.nl

The Escherichia coli replication initiator DnaA is titrated on the chromosome

DNA replication initiation is orchestrated in many prokaryotes by the replication initiator DnaA. Two models for regulation of DnaA activity in Escherichia coli have been proposed: the switch between ...

doi.org

A dynamic 3D polymer model of the Escherichia coli chromosome driven by data from optical pooled screening

The DNA of bacterial cells is organized in a highly dynamic chromosome structure. To guarantee its propagation, the chromosome must replicate, segregate, and accommodate other biological processes lik...

biorxiv.org

A rugged yet easily navigable fitness landscape

A high number of genetic fitness peaks does not impair adaptive evolution in a large empirical fitness landscape.

science.org