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Dvir Schirman

@dvirschirman.bsky.social

@EMBOFellows postdoc in @johan_elf_ lab, @UU_University. Chromosome organization in bacteria. Combining microscopy and large synthetic libraries to study genotype-to-phenotype. alumnus of @TPilpel lab

34 Posts417 Follower564 Folgt
José Aguilar-Rodríguez@jaguilarrod.bsky.social · 10mo ago

One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential. www.biorxiv.org/content/10.1...

Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation

The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...

biorxiv.org

Itai Yanai@itaiyanai.bsky.social · last yr.

There's a lot of joy in doing science and Woodstock Night Science (June 10-13 in Prague) will be a celebration of the science that we know and love. Many exciting talks & innovations that will push the boundaries of what a scientific conference can really do. woodstock.img.cas.cz Only 40 spots left!

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Séamus Holden 🔬🦠🧫@seamusholden.bsky.social · last yr.

Fellow bacterial cell biologists, message me if you use @thermofishersci.bsky.social Gene Frames for microscopy! Thermo are planning to discontinue these in September but have indicated they will look into this further. If I make list of labs using them Thermo might not kill the product Please RT🔬🦠

Live Cell Imaging of Bacillus subtilis and Streptococcus pneumoniae using Automated Time-lapse Microscopy

42.1K Views. University of Groningen. This protocol provides a step-by-step procedure to monitor single cell behavior of different bacteria in time using automated fluorescence time-lapse microscopy....

jove.com

Will Ratcliff@wcratcliff.bsky.social · last yr.

1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social. www.nature.com/articles/s41...

Genome duplication in a long-term multicellularity evolution experiment - Nature

In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its...

nature.com

Sri Kosuri@srikosuri.bsky.social · last yr.

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

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Di Jiang@dijiang319.bsky.social · 2y ago

This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/... #microsky #microbial #microbiology #genomics #transcriptomic 🦠🧫

Highly multiplexed spatial transcriptomics in bacteria

Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...

science.org

Grainger Lab@graingerlab.bsky.social · 2y ago

If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)

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Arne Elofsson@handle.invalid · 2y ago

We are excited to announce that the call for the new SciLifeLab PULSE postdoctoral program is now open! This unique program invites talented researchers to propose individually designed projects see : www.scilifelab.se/research/pul.... The deadline for applications is March 31, 2025.

PULSE

SciLifeLab PULSE: Program for Future Leaders in Life Science SciLifeLab PULSE is a comprehensive postdoctoral program, that will train 48 future leaders in life sciences. PULSE focuses on innovative, ...

scilifelab.se

Dvir Schirman@dvirschirman.bsky.social · 2y ago

I’m excited to share the first preprint from my postdoc at @johan_elf_ lab together with Konrad Gras. 🧬🦠 biorxiv.org/content/10.1... (1/14)

A dynamic 3D polymer model of the Escherichia coli chromosome driven by data from optical pooled screening

The DNA of bacterial cells is organized in a highly dynamic chromosome structure. To guarantee its propagation, the chromosome must replicate, segregate, and accommodate other biological processes lik...

biorxiv.org

Rike Stelkens@stelkens.bsky.social · 2y ago

Thinking about moving (now more than ever?): Here’s a great postdoc funding opportunity if you’d like to join the academic community in Sweden. Happy to act as your host lab, if you’re interested in evolution and genomics in yeast www.scilifelab.se/research/pul...

About the PULSE program

About the PULSE program PULSE builds upon and further leverages the unique SciLifeLab community, fostering excellence in biology-, technology-, and data-driven research. The program emphasises key res...

scilifelab.se

Will Ratcliff@wcratcliff.bsky.social · 2y ago

New preprint up! We sequenced hundreds of samples from across one of Earth's oldest living organisms - the Pando aspen clone - to understand how mutations accumulate and spread in long-lived clonal organisms. Our results were…surprising. 1/30

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