Simone Immler
@immler.bsky.social
Professor of Genetics & Reproduction, University of East Anglia Founder and Scientific Director, Virilitas Labs
Delighted to see our work picked up by @theguardian.com this is a real window of opportunity for us to reduce carbon emissions to give the bears a hope at survival before it really is too late.
The Guardian@theguardian.com · 8mo agoChanges to polar bear DNA could help them adapt to global heating, study finds
🐻❄️❄️ New paper alert! From me Ben & @immler.bsky.social “Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉 link.springer.com/article/10.1... A thread 🧵. #climate #transposons #TESky #polarbear #ursus @biouea.bsky.social
Diverging transposon activity among polar bear sub-populations inhabiting different climate zones - Mobile DNA
Mobile DNA - A new subpopulation of polar bears (Ursus maritimus) was recently discovered in the South-East of Greenland. This isolated colony inhabits a warmer climate zone, akin to the predicted...
link.springer.com
The future of polar bears? Amazing work, @alicegodden.bsky.social, Ben Rix and @immler.bsky.social. #UEAScience 🐻❄️
Alice Godden@alicegodden.bsky.social · 8mo ago🐻❄️❄️ New paper alert! From me Ben & @immler.bsky.social “Diverging transposon activity among polar bear sub-populations inhabiting different climate zones” (Godden, Rix & Immler, 2025). 👉 link.springer.com/article/10.1... A thread 🧵. #climate #transposons #TESky #polarbear #ursus @biouea.bsky.social
1/6 New preprint! Do changes to insulin/IGF-1 signalling (IIS) that extend lifespan also protect the germline, or do they come with a mutational cost? led by @eduxbury.bsky.social with @alicegodden.bsky.social @immler.bsky.social Johnny de Coriolis Hanne Carlsson www.biorxiv.org/content/10.6...
Lifespan-extending downregulation of insulin signalling reduces germline mutation load
Reduced insulin/IGF-1 signalling (IIS) robustly extends lifespan and enhances somatic stress resistance across taxa, yet its consequences for germline genome integrity remain unclear. Here we combine ...
biorxiv.org
Very happy to share this large-scale study from my postdoc with @alexeimaklakov.bsky.social. Lifespan-extending downregulation of insulin signalling reduces germline mutation load. Many thanks to our collaborators @alicegodden.bsky.social @immler.bsky.social Johnny de Coriolis and Hanne Carlsson.
Alexei Maklakov@alexeimaklakov.bsky.social · 8mo ago1/6 New preprint! Do changes to insulin/IGF-1 signalling (IIS) that extend lifespan also protect the germline, or do they come with a mutational cost? led by @eduxbury.bsky.social with @alicegodden.bsky.social @immler.bsky.social Johnny de Coriolis Hanne Carlsson www.biorxiv.org/content/10.6...
🧬 Our latest paper out in Scientific Reports! We explored how Gum Arabic (a dietary fibre) affects the microbiota–gut–brain axis and whole-organism fitness in zebrafish. 🔗 www.nature.com/articles/s41... @immler.bsky.social @biouea.bsky.social What we found ⬇️
Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish - Scientific Reports
Scientific Reports - Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish
nature.com
This is a simple parsimonious model to explain the evolution of lifespan extension by dietary restriction and other forms of stress that suppress fertility. Happy to be part of this exciting study!
Alexei Maklakov@alexeimaklakov.bsky.social · last yr.Why does eating less extend lifespan? 🧬 Mutation accumulation underpins evolution of lifespan extension by dietary restriction We often think about saving energy or recycling waste - but we show how evolution acting on mutation load can generate longer life on low food 🧵 🔗 tinyurl.com/jn5ryhxv
1/7: Proud to present our next study on aging microbiome - a massive experimental effort led by the Rosenstiel and Sommer labs and contributions by @sci-witch.bsky.social. @uni-kiel.de @crc1182.bsky.social microbiomejournal.biomedcentral.com/articles/10....
Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice - Microbiome
Background Alterations in the composition and function of the intestinal microbiota have been observed in organismal aging across a broad spectrum of animal phyla. Recent findings, which have been der...
microbiomejournal.biomedcentral.com
🔬 My latest work w/ @immler.bsky.social et al: Env. stress alters sperm sRNAs, linking gene expr. + transposons in #zebrafish offspring. @heredityjournal.bsky.social 🧬 Social stress shapes RNA/TE activity across generations #Sperm #miRNA #piRNA #Transposons #TEsky @biouea.bsky.social rdcu.be/eeAwB
Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring
Heredity - Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring
rdcu.be
A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.
go.nature.com
Happy International Women in Science day! I owe a lot to all of you that I met along the way, as my supervisors, mentors, friends, colleagues, PhD students, postdocs, research assistants, daughters, mothers and… and.. and…
Celebrate 'International Day of Women and Girls in Science Day' by strengthening your timeline with these outstanding Scientists! *Now in two volumes below* 🧪 #WomenInScience (Volume 1): go.bsky.app/4BegEjv #WomenInScience (Volume 2): go.bsky.app/VoebYrt
🚀 Join us to learn about genome assembly, and annotation, exploring cutting-edge sequencing tech like Illumina @pacbio.bsky.social , @nanoporetech.com 🧬🔬 Don't miss out—join us: www.physalia-courses.org/courses-work... #Genomics #Bioinformatics #GenomeAssembly
IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social 10-13 of June in Prague & the Woods of Bohemia... Be there or be REJECTED. #theconferencetoendallconferences
New model of premature #aging in #zebrafish 👏 "Loss of wrn leads to a short lifespan and age-related characteristics in the intestine of zebrafish embryos, such as cellular senescence, genomic instability, and epigenetic alteration." Go Fish! 🐟 www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Join our online course on Genome-Wide Prediction of Complex Traits with @oscargenomics.bsky.social & Evangelina (March 24-28). You will learn the essential steps to implement genome-wide prediction analyses in animals, plants and humans Limited spots! 👉 www.physalia-courses.org/courses-work...
GENOME-WIDE PREDICTION OF COMPLEX TRAITS
Dates 24-28 March 2025 To foster international participation, this course will be held online
physalia-courses.org
Hand-drawn images of larval and juvenile zebrafish. Credit to @stednitz.bsky.social. #ZebrafishZunday 🧪
Try our new in silico PCR (sPCR) tool sharkmer- github.com/caseywdunn/s.... You give it primers and fastq reads, it gives you sequences that would be amplified by PCR. Works in minutes on a laptop for high copy regions like rRNA, great for species id etc. Feedback welcome. #bioinformatics #ngs
GitHub - caseywdunn/sharkmer
Contribute to caseywdunn/sharkmer development by creating an account on GitHub.
github.com
If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea! And enjoy the fish 🐟 eating the Pi(e) 🥧
Alice Godden@alicegodden.bsky.social · 2y ago🚨Our new paper @immler.bsky.social @biouea.bsky.social 🚨 FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements Read now in Mobile DNA >> rdcu.be/d7Jub ✅ Covers many species (more to come) ✅ GUI based software #TESky #zebrafish #transposons @zebrafishrock.bsky.social
FishPi software is freely available here: github.com/alicegodden/...
GitHub - alicegodden/fishpi: piRNA TE analysis tool
piRNA TE analysis tool. Contribute to alicegodden/fishpi development by creating an account on GitHub.
github.com
Alice Godden@alicegodden.bsky.social · 2y ago🚨Our new paper @immler.bsky.social @biouea.bsky.social 🚨 FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements Read now in Mobile DNA >> rdcu.be/d7Jub ✅ Covers many species (more to come) ✅ GUI based software #TESky #zebrafish #transposons @zebrafishrock.bsky.social
If you are interested in the biological function of piRNAs and how they interact with TEs, this is the tool for you (for any organism with relevant info available) - full credit to @alicegodden.bsky.social who came up with this brilliant idea! And enjoy the fish 🐟 eating the Pi(e) 🥧
Alice Godden@alicegodden.bsky.social · 2y ago🚨Our new paper @immler.bsky.social @biouea.bsky.social 🚨 FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements Read now in Mobile DNA >> rdcu.be/d7Jub ✅ Covers many species (more to come) ✅ GUI based software #TESky #zebrafish #transposons @zebrafishrock.bsky.social
The maintenance of genetic polymorphism underlying sexually antagonistic traits doi.org/10.1093/evle... Now in @evolletters.bsky.social by Ewan Flintham et al.
The maintenance of genetic polymorphism underlying sexually antagonistic traits
Abstract. Selection often favors different trait values in males and females, leading to genetic conflicts between the sexes when traits have a shared gene
doi.org
Reversing Type 2 diabetes A randomized trial of an SGLT-2 drug and moderate caloric restriction (vs placebo drug) led to remission in 44% vs 28% in the control group
Tour de force! @metorrespadilla.bsky.social & team develop Smart-seq+5′ to map TSS in single embryos with unprecedented res revealing plethora of TE-driven transcripts in 5 mammal species. Some surprisingly old & conserved. Treasure trove of new biology for yrs to come! www.cell.com/cell/fulltex...
An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development
Mapping transcription start sites across five mammalian species before, during, and after embryonic genome activation unveils widespread transposable element-driven transcription and co-option of evol...
cell.com
I still enjoy looking at zebrafish embryos even after many years. New lab members and students seeing them for the first time never fail to express their amazement
Peter Fabian@fabianlab.bsky.social · 2y agoDeveloping #zebrafish embryos about 18 hours post fertilization. Can you see the tail or eye?
A great end to 2024: The Zebrafish Sperm Proteome analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/... We described >5400 sperm proteins! Spearheaded by PhD student Jayme Cohen in collaboration with many people at @uniofeastanglia.bsky.social @johninnescentre.bsky.social
The Zebrafish Sperm Proteome
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closel...
analyticalsciencejournals.onlinelibrary.wiley.com
A great end to 2024: The Zebrafish Sperm Proteome analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/... We described >5400 sperm proteins! Spearheaded by PhD student Jayme Cohen in collaboration with many people at @uniofeastanglia.bsky.social @johninnescentre.bsky.social
The Zebrafish Sperm Proteome
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closel...
analyticalsciencejournals.onlinelibrary.wiley.com
🚨New paper from @immler.bsky.social lab Led by Jayme Cohen doi.org/10.1002/pmic... On the #Zebrafish #sperm proteome out now! 🐠
The Zebrafish Sperm Proteome
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closel...
doi.org
