Melissa E. Murray
@drneurochic.bsky.social
Digital pathology guru | Biomarker enthusiast | Hopeful scientist | Scientific program committee @HAIconference #AAIC25 | Advisory board #ADPD2025
🚨New in Lancet Neurology: Autopsy study of aducanumab in #Alzheimer’s shows superficial cortical Aβ cleared, but deeper persists. ARIA showed inflammation+ microinfarcts in leptomeningeal/penetrating vessels. Some path is PET-invisible. @drneurochic.bsky.social authors.elsevier.com/a/1lxn85FFzL...
Why some people have more fit brain cells at 90 when others’ start dying at their 30s? Hard to say! It is hard to study because human 🧠 is the least accessible. @drneurochic.bsky.social et al discuss how to accelerate biomedical discoveries in brain health via transformative neuropathology. (1/5)
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
Murray et al. introduce “transformative neuropathology” through dynamic, technology-integrated approaches to accelerate tissue-based discoveries and offer actionable strategies to strengthen brain ban...
cell.com
Every day is #InternationalWolfDay in our eyes, but today’s a great reminder of how amazing wolves are! 🐺 Support wolf recovery and conservation by donating or advocating for stronger protections. 🌎🐾 Learn more about ways to make an impact: nywolf.org
Interested to see how advanced microscopy holds the power to transform our understanding of therapeutics🔬🧠…come see our latest work. #AAIC25 Hall G session 2-3.30 pm integrative neuropathology in ADRD at 2.20 pm sharp @drneurochic.bsky.social
@alzassociation.bsky.social #GlobalImmersionExperience reception at Thompson Landry Gallery #Toronto
NEWSFLASH #2: @alzassociation.bsky.social commits over $40M to translate the positive outcomes of #USPOINTER #structuredlifestyleintervention to preserve your 🧠 💜 # ENDALZ 💪🏼 from global to local.
You can still be a grown a** adult and have an "I forgot my homework nightmare" ...There I sat in an audience and they call me as the next speaker and also from stage ask where my talk was😱 double booked today for two talks might have something to do with it😆 I'm excited though and pptx ready 💪
🧠 New preprint alert! We are excited to present the neurofibrillary tangle maturity scale, which integrates tangle maturity scores of pretangles, mature tangles, and ghost tangles to summarize tangle maturity predilection in the tissue. @drneurochic.bsky.social www.biorxiv.org/content/10.1...
The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer's Disease
Neurofibrillary tangles are dynamic neuropathologic hallmarks of Alzheimer's disease with a hypothesized lifespan morphologically-defined by three maturity levels: pretangles, mature tangles, and ghos...
biorxiv.org
academic.oup.com/brain/articl... My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!
Models of autoantibody mediated diseases: actively nearing the human gold standard
Human autoantibody-mediated diseases associated with a single autoantigenic target provide several valuable opportunities for precision medicine.1 The impl
academic.oup.com
Nominate a deserving early-career investigator today for a chance to attend #CCAD2026. If selected, they will compete for a $100,000, 2-year grant from #NewVisionResearch! View nomination criteria here 👉 newvisionresearch.org/ccad-2026/ Nominate here 👉 airtable.com/appjJE7FUGZY...
Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉 authors.elsevier.com/a/1l7l75FFzL...
authors.elsevier.com
Learn about (generative) modeling in #ComputationalPsychiatry by attending the #CPCZurich2025. The BEST course for learning about different models (incl. tutorials), best practices, math backgrounds, and showcase your research in the poster session: www.translationalneuromodeling.org/cpcourse/
Computational Psychiatry Course Zurich
An educational course about computational psychiatry from UZH & ETH Zurich.
translationalneuromodeling.org
Curse of Neuroanatomy Training Part 4. Tessellation of Mona Lisa, but looks like gyri to us. Thanks to Dr. Jeff Browndyke. Original post by Kevin Atkinson Mathematical Tiling and Tessellation. #neuroskyence
ATTENTION New crowdsourced site collecting and sharing stories of public impact of research publicusaresearchbenefits.com Take a look and consider contributing. Let's make this as powerful as possible!
Searchable database of tangible benefits that federally-funded research gave us.
A crowd-sourced site. Health and Well-being. National Security. Prosperity.
publicusaresearchbenefits.com
quite extraordinary story. Sometimes I think it’s the weird people that will save the world,
Dustin Moskovitz@moskov.goodventures.org · 2y agowww.bbc.com/news/article...
Today a pupal #Drosophila #Brain (40 h APF) for #fluorescencefriday. 🔵 Actin 🟠🟡 Anti-E-Cad depth-coded color I have 1 million versions of this picture, in which I tried different LUTs. I will put some in the comments! #microscopy #cellbio #neuroscience #insect
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems. @jonykipnis.bsky.social www.nature.com/articles/s41...
Redefining CNS immune privilege - Nature Reviews Immunology
In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...
nature.com
For #FluorescenceFriday - new experiments that I am really excited for! Really pretty tyrosine hydroxylase (TH) 🟢 labeling in human induced pluripotent stem cells that are differentiating into locus coeruleus-like cells. Image credit to the @lieberinstitute.bsky.social Imaging Development team 🧠🧪🔵
So excited and honored to be invited to present the opening plenary at #AIC2025 this year in Toronto! 🧠 🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this ~5min survey: alz.surveymonkey.com/r/923BTQK
Anika Wuestefeld, PhD@anikawuestefeld.bsky.social · 2y ago🚨Calling all neuroimagers! Help @emmacoomans.bsky.social shape the opening plenary at #AIC2025 (Toronto, July 26th) "Accomplishments of the Past Year" and share the most impactful neuroimaging research from the past year via this brief survey (~5min) by May 30th. act.alz.org/site/R?i=eOe...
Huge congratulations to Professor Bess Frost on receiving your well-deserved Rainwater prize at #Tau2025🎉👏👏👏 Loved hearing your journey and resolve to dig in deeper when naysayers may have prevented your innovative discoveries rainwatercharitablefoundation.org/honoring-exc...
Honoring Excellence: Dr. Bess Frost Receives 2025 Rainwater Prize - Rainwater Charitable Foundation
The Rainwater Charitable Foundation (RCF) is proud to award Bess Frost, Ph.D., Brown University, with the 2025 Rainwater Prize for Innovative Early-Career Scientist of $200,000. The Rainwater PrizeTM ...
rainwatercharitablefoundation.org
Bess Frost@bessfrost.bsky.social · 2y agowww.science.org/content/arti...
Love seeing the beautiful butterfly at #Tau2025 where 1000+ scientists and clinicians are gathering to share ideas to accelerate biomedical discoveries. Here is a starter pack to quickly follow TAUrrific researchers. Let me know if I need to add anybody go.bsky.app/KHno2VG @millermb.bsky.social
Melissa E. Murray@drneurochic.bsky.social · 2y agoWith so many great tau researchers like @leatgrinberg.bsky.social @lucbuee.bsky.social @sjorsscheres.bsky.social @selinawray.bsky.social @karchlab.bsky.social on #SciSky could not help but put together my 1st starterpack⤵️ We are all fighting for you @curemaptftd.bsky.social 💙 go.bsky.app/KHno2VG
“The highest forms of understanding we can achieve are laughter and human compassion.”
Incredibly exciting times for regenerative medicine. Very happy to see the truly groundbreaking work led by the Tabar and Studer labs published. Huge congrats to all those involved!
Eric Topol@erictopol.bsky.social · 2y agoIt has taken decades to get to this point, but stem cells for Parkinson's disease showing promise in 2 clinical trials nature.com/articles/d41... nature.com/articles/s41... nature.com/articles/s41...
Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out! We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections! www.nature.com/articles/s41...
The diversity of CD8+ T cell dysfunction in cancer and viral infection - Nature Reviews Immunology
Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...
nature.com
I have over 2,000 followers. I never got to 800, after YEARS at The Letter. #ThankYou to the ~thirty people who actually check on me, for believing that I might have the occasional snippet worth reading. You are cherished. 🥰🙏🎉 -E
What a start for the inaugural Center for Neurodegenerative Disorders, featuring superstars @malutansey.bsky.social and @elizabethhead.bsky.social giving keynotes!
