🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de published in @natneuro.nature.com: We developed a highly reproducible 3D human brain tissue model (3BTM) that enables studying microglial phenotypes in health and disease! #OA PDF here: rdcu.be/fxLou Thread👇: 1/11

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n

Intestinal stem cells count self-renewal divisions to switch multipotency @nature.com www.nature.com/articles/s41... www.nature.com/articles/d41...

🍰Read also the News & Views article written by Roman A. Romanov: 👉https://rdcu.be/fwgUy www.nature.com/articles/s41...

Primate neurons with special signalling logic - Nature Cell Biology

Von Economo neurons are linked to higher cognition but remain poorly understood. A study now combines Patch-seq and transcriptomics in macaques to define their molecular identity, diversity and signal...

nature.com

Online Now! Dissecting divergent outcomes in stem cell-derived dopamine cell therapy trials for Parkinson’s disease #stemcells

Priscillia Lhoumaud and I were very happy to write a N&V for a monster paper about intriguing DNMT1 biology by @mafdawson.bsky.social and co, just out in @natgenet.nature.com . Check it out here (and the actual paper in the next post) (1/2) www.nature.com/articles/s41...

SUMOylation fine-tunes DNMT1 to silence viral mimicry transcripts - Nature Genetics

DNMT1 binds unmethylated CpG islands at active genes and, upon catalytic inhibition, redistributes to partially methylated, inaccessible regions, triggering viral mimicry via endogenous retroelements ...

nature.com

1/4 Every good defence needs a backup! 🛡️⚔ Out now in @natrevmicro.nature.com our Comment on "𝗶𝗺𝗺𝘂𝗻𝗲 𝘀𝗮𝗳𝗲𝗴𝘂𝗮𝗿𝗱𝗶𝗻𝗴"! 🎉 🔗 www.nature.com/articles/s41...

Immune safeguarding as a conserved principle of antiviral defence - Nature Reviews Microbiology

All organisms defend against viral infections through active immunity mechanisms that clear the virus or population-level mechanisms that cause regulated cell death. Recent research increasingly shows...

nature.com

New from @vmetzis.bsky.social & co Vagal & trunk neural crest cells share transient epiblast origin, but temporal regionalisation preconfigures their identity before crest induction Cdx1 acts before Cdx2, setting distinct chromatin and HOX state in the epiblast www.biorxiv.org/content/10.6...

Temporally distinct CDX programmes preconfigure vagal and trunk neural crest

Neural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...

biorxiv.org

I'm looking for a postgraduate intern to join my group at @humantechnopole.bsky.social, modelling how pili dynamics drive bacterial motility and aggregation. Finishing a master's in physics, computational biology, or a similar field? Get in touch: careers.humantechnopole.it/job/Internsh...

For the neural crest nerds: we love looking into transcriptional programs in single NCC cells. However, selective ribosomal modifications refine gene expression programs at a different scale. Here is our story about modified ribosomes in neural crest fate selection: www.nature.com/articles/s41...

Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage - Nature Communications

Neural crest cells differentiate into skeletogenic mesenchyme and neuro-glial lineages, thereby contributing to craniofacial formation. Here, single-cell analysis of cranial neural crest shows that sp...

nature.com

Our article, led by the remarkable Xiangling Meng, on establishing CRISPR screens in neural #assembloids and #organoids is on the cover of Nature Protocols today

Have a favorite European colleague who should be recognized for their work in non-medical biotechnology? Pls nominate them for the Novo Nordisk Foundation Prize for Biotechnology. (Prior awardees at novonordiskfoundationprize.com/awardees). Thank you! novonordiskfoundationprize.com/nominate-bio...

The Novo Nordisk Foundation Prize

Our prizes are awarded to researchers who have contributed to scientific breakthroughs or in other ways distinguished themselves within natural or medical science.

novonordiskfoundationprize.com

RNA can build. A short RNA self-assembles into a 60-subunit icosahedral cage like a viral capsid, but made entirely of RNA. The striking preprint also reveals a 57-nt RNA filament at ~2.7 Å. Congratulations, Lin Huang and colleagues! www.biorxiv.org/content/10.6...

Please RP! Excited to share our new preprint: “Single-cell chromatin tracing reveals multimodal molecular programs during memory formation” We built a single-cell multiomic atlas of aversive learning and used it to trace memory-linked molecular programs. doi.org/10.64898/202...

Probably the coolest location I have ever had the opportunity to give a seminar. The Naturalis museum in Leiden, this year’s venue for the @embo.org Workshop “Pathogen Immunity and Signalling”. Big thanks to the organizers for putting together an amazing meeting.

Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...

Minimal essential requirements for neural tube self-organisation

The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...

biorxiv.org

Incredibly excited to be heading to the EMBO Workshop “Pathogen Immunity and Signalling”. If you’re there and want to connect, please reach out!

EMBO@embo.org · 5mo ago

Explore #immunology, #virology, #microbiology and more at the EMBO Workshop "Pathogen Immunity and Signalling" in #Leiden, Netherlands, 8–11 June 2026. Registration deadline: 15 March https://meetings.embo.org/event/26-pathogen-immunity #EMBOpathogenSignalling #EMBOevents 🧪

MouseMapper An imaging-omics workflow of whole-mouse analysis Up to single-cell resolution!👹 vDISCO WildDISCO whole-mouse optical clearing #SpatialProteomics Trigeminal ganglia VR annotation of major organs, peripheral nerve & Mφ @erturklab.bsky.social Nature 2026 www.nature.com/articles/s41...

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬 Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std? The answer surprised us 🧵 www.biorxiv.org/content/10.6...

In this Viewpoint, Søren Paludan @au.dk and Sara Cherry @pennmedicine.bsky.social reflect on the recent #hantavirus outbreak and discuss the need for a better understanding of the different phases of viral diseases to improve treatment. rupress.org/jem/article/...

www.cell.com/cell-stem-ce... Check this out

Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems

Zeng et al. develop human sinoatrial node-plexus assembloids integrating pacemaker and autonomic neural organoids and incorporating atrial organoids to model the neural-pacemaker-atrial conduction axi...

cell.com

www.nature.com/articles/s41...

Spatiotemporal transcriptome atlas of human embryos after gastrulation - Nature

A spatiotemporal transcriptome atlas of whole-human embryos after gastrulation and previously transcriptionally undescribed stages of human development are reported.

nature.com

🔬 What if one fluorescence image could reveal several cellular structures at once? 🤖 Our @florianjug.bsky.social Group developed Micro𝕊plit, an #AI tool published in @natmethods.nature.com that helps split overlapping microscopy signals. Read more 👉 humantechnopole.it/en/news/when...

When less is more: optimising fluorescence microscopy with Micro𝕊plit - Human Technopole

Researchers at Human Technopole have developed a novel machine learning-based method that transforms composite fluorescence microscopy images with overlapping signals into separate images revealing in...

humantechnopole.it

PL retweet. Developmental Biology Course (Quintay). More information: biodesarrollo.unab.cl

A big shout out to the organising committee and the whole PhD community who made this retreat such a success! An inspiring group of young researchers, with whom it's a privilege to work.

Human Technopole@humantechnopole.bsky.social · 3mo ago

🌱 A milestone for our #PhD community: the 1st Human Technopole PhD Retreat brought our doctoral students together for two days of science, growth and connection at Mantello. #PhDlife

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Still time to apply! Deadline extended to 25th May! This is an enriching, immersive, interactive week of talks and discussions with leaders in the field. A brilliant oppportunity for PhD students, postdoc, new PIs. See our testimonials: www.stemcellsummerschool.org/testimonials Spread the word!

Stem Cell Summer School@stemcellsummer.bsky.social · 5mo ago

We are delighted to announce that we are now open for applications for 2026 summer school Dates: 11th - 18th September 2026 Deadline for applications: 8th May See our website for info on how to apply.. and to check out our stellar speaker list! www.stemcellsummerschool.org/apply 🧪

📢 New preprint alert ! www.biorxiv.org/content/10.6... Joanna Dembska developed a highly scalable image-base screening platform for protein turnover modulators in human neurons, based on our fluorescent timer system. Protein turnover is perturbed in nearly all neurodegenerative diseases ...

The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes www.nature.com/articles/s41... @natcomms.nature.com