Hämälistö, @fadelvalle.bsky.social, Yuseff, and @mattilalab.bsky.social review how #BCells have adopted specialized ways to use endolysosomal vesicles to promote adaptive immune responses. rupress.org/jcb/article/... 📕 Part of #Lysosomes 2026: rupress.org/jcb/collecti...
Felipe del Valle Batalla
@fadelvalle.bsky.social
Cell biologist - PhD. What’s a cell? How does it really work? Why do we care? Loving running, reading, microscopy and coffee. Opinions are my own. fadelvalle.github.io Donlin-Asp Lab University of Edinburgh
From cells to amino acids: 1000ExM pushes expansion microscopy even further 🔬 #microscopy @fadelvalle.bsky.social covers an impactful #preprint from the labs of @bergerlab.bsky.social, @alishaib.bsky.social, Silvio Rizzoli & @eboyden3.bsky.social #preLight⬇️ prelights.biologists.com/highlights/t...
Thousandfold Expansion Microscopy - preLights
From cells to amino acids: 1000ExM pushes expansion microscopy beyond 1000×, potentially resolving individual protein residues on standard microscopes. Bigger volume expansion opens a new frontier for...
prelights.biologists.com
🚨 First preprint from the lab! @pdaphd.bsky.social summarises the findings in this thread. Congrats to @rhyslivingstone.bsky.social and @pdaphd.bsky.social for all the hard work I’ve witnessed 🎉🥳
Extremely excited to share the first preprint from the lab, led by postdoc @rhyslivingstone.bsky.social www.biorxiv.org/content/10.6... What has he found? 1/7
Thanks to @jcb.org for featuring my PhD work ! So many interesting articles in this collection 🔥
B cell mechanotransduction via ATAT1 coordinates #actin & lysosomal dynamics at the immune synapse. From Pablo Aceitón, Isidora Riobó, @fadelvalle.bsky.social, María Isabel Yuseff et al. rupress.org/jcb/article/... 📕 From JCB Immune Cell Biology collection 👉 rupress.org/jcb/collecti... #AAI2026
The 2025 ASAPbio Fellows examined how large language models (LLMs) handle, interpret, and communicate information from preprints compared to peer-reviewed journal articles. The new blog post discussed their findings👇️ buff.ly/SSglQZG
Interim Findings From An Investigation Into LLM Responses About Preprints: A 2025 ASAPbio Fellows Project – ASAPbio
Contributors: Felipe Del Valle Batalla, Barakat Bakhit, Akanksha Gupta, Kendra Parson, Emiliya Taskova
asapbio.org
Best comment and summary of the whole situation
I prefer scientists like our colleague Doug Zonkger, who are willing to put in the work.
"AI tools are democratizing Coding" My dude, R and Python are free and open-source
Happy fluorescence Friday ! First one of the year :)
In a short time, we’ll have fake AI scientists fabricating fake AI results reviewed by fake AI reviewers. This data will then be text-mined by AI and ultimately delivered to mindless AI consumers.
Finally the scary example. The image of a western blot with a time course experiment, staining a protein of interest, showing the increase of protein over time and a second staining with a control antibody that does not change over time
I love to see the endoplasmic reticulum (ER, cyan) hitchhiking over microtubules (MTs, orange). Also the membrane dynamics are lovely. It's been a while, but here we are for a late #fluorescencefriday with some #microscopy #scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
Not all colormaps are created equal. Notice the nonlinear brightness scaling in two very popular ImageJ LUTs! (Glow & GFB)
This is what I actually signed up for ❤️ gloomy scientific vibes 🏴
As per usual: NEVER. Enough. L U T S
I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager! I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...
Happy October 1st! A good time to share another #CellBio #preprint reading list put together by a team of preLighters: @sristi.bsky.social, Matthew Davies, @vibhasingh.bsky.social, @fadelvalle.bsky.social & Barbora Knotkova. Check out their picks ⬇️👀 prelights.biologists.com/prelists/sep...
September in preprints – Cell biology edition - preLights
prelights.biologists.com
Could run forever with these views 🏴
I'm very happy to finally be able to show what I have been working on for the last years (with help of @sarahdezperez.bsky.social and Elmeri)! @mattilalab.bsky.social @inflames-flagship.bsky.social @utu.fi www.biorxiv.org/content/10.1...
Dynamic Micropatterning Reveals Spatial Dynamics of B Cell Receptor Signaling and Immune Synapse Formation
B cell activation by foreign antigens, recognized by the B cell receptor (BCR), is the key prerequisite for cell differentiation for antibody production. B cells typically encounter antigens bound to ...
biorxiv.org
preLighters go live! A light and lively face-to-face conversation between the preLighters @fadelvalle.bsky.social & Vibha Singh and the researchers probablycarmen.bsky.social & Eva Mejia-Ramirez will be hosted at the @focalplane.bsky.social webinar. 4 Sept, 14.00-15.00 BST Tune in!
preLighters go live! This Thursday - preLights
– How do membrane actin protrusions initiate to T-cells signalling? – What does RhoA have to do with nuclear envelope tensions in stem cells? – Does advanced microscopy help study mechano-signalling –...
prelights.biologists.com
Hope to see you there !
#FocalPlaneFeatures meets @prelights.bsky.social @fadelvalle.bsky.social & Vibha Singh have picked 2 fantastic #cellbio preprints & will be presenting their preLights alongside research talks from @probablycarmen.bsky.social & Eva Mejia-Ramirez. Register: focalplane.biologists.com/2025/08/20/f...