@mileshuseyin.bsky.social and the lab have put together a comprehensive protocol for genome-wide Micro-C and for Region-Capture Micro-C in @natprot.nature.com : www.nature.com/articles/s41... See also the GitHub for a user-friendly end-to-end computational pipeline: github.com/ahansenlab/M...

Nature Protocols@natprot.nature.com · 3w ago

New Article! Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC)

Amazing new method for live-cell imaging of RNA molecules developed by Adam in the Brockdorff lab! Worth having a look at!

bioRxivpreprint@biorxivpreprint.bsky.social · 4w ago

Nuclear-BRITE: an enhanced MS2 system for live-cell imaging of nuclear RNAs https://www.biorxiv.org/content/10.64898/2026.07.07.736975v1

Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...

Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers

Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac...

biorxiv.org

"the first validated, large-scale framework for judging the quality of life science papers independently of venue, identity, and prestige...Blinded domain-expert professors sided with score three times more often than with journal rank" the-one-percent.qedscience.com 1/n

Gloves are off! TODAY WE RELEASE THE 1% A list of the year’s very best papers 👇 (see thread)

Best news on such a hot day! Congratulations @au-ho-yu.bsky.social and @robklose.bsky.social - an amazing achievement! Alan has done an amazing job and is currently working hard to address the reviewers' concerns! Comments came took 4 months to come back - reviewer 2 doesn't agree with g.e.d!

QED Science@qedscience.bsky.social · last mo.

🎉 Meet The 1%. Out of 57,455 bioRxiv life science preprints, QED Science selected 574 exceptional manuscripts through blind evaluation. The 1%: the-one-percent.qedscience.com Good science deserves to be seen. @biorxivpreprint.bsky.social @openrxiv.bsky.social @richardsever.bsky.social

We looked at 57,455 preprints. No names. No institutions. No reputations. Just the science❕ In 48 hours, we reveal The 1%. #The1Percent #QEDScience #Preprints

This study led by @flavia-con.bsky.social from the Brockdorff lab is finally published at Nature Communications! www.nature.com/articles/s41... Using live-cell and single-molecule imaging, this work dissects how the epigenetic regulator #SMCHD1 interacts with chromatin during X-inactivation.

Guifeng Wei@guifengwei.bsky.social · last yr.

Fresh preprint by @flavia-con.bsky.social from our lab uncovers how SMCHD1 finds & binds chromatin using live-cell single-molecule imaging🔬 She reveals how SMCHD1 dynamically engages chromatin, including the inactive X chromosome, to maintain gene silencing. www.biorxiv.org/content/10.1...

Yaay! Well done @bluebuleta.bsky.social and team! Great to see this work finally out! Read the paper to see how SETDB1 and HUSH regulate Xist transcription

Mafalda Almeida 🇵🇹 🇪🇺 🇬🇧@bluebuleta.bsky.social · 2mo ago

🧵 Happy to share that the final version of our study is finally out in @natcomms.nature.com today: www.nature.com/articles/s41... What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.

Unacceptable! Have people started asking for refunds? We don't use Thermo antibodies much but have a couple in the freezer (one I have to admit is good!)

Reese Richardson@reeserichardson.bsky.social · 2mo ago

Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times. www.thermofisher.com/us/en/home/l...

Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!

Congratulations @robklose.bsky.social for being elected as a Fellow of the Royal Society! royalsociety.org/news/2026/05... great news to have two outstanding scientists, Rob and Colin, from @oxfordbiochemistry.bsky.social joining the Royal society today!

Exceptional scientists elected as Fellows of the Royal Society | Royal Society

Over 90 outstanding researchers from across the world have this year been elected to the Fellowship of the Royal Society, the UK’s national academy of sciences.

royalsociety.org

Today we celebrate our colleagues Colin Kleanthous and Rob Klose as they join the Fellowship of the Royal Society, one of the highest honours in the scientific world, in recognition of their impactful contributions to knowledge. Congratulations! 👏 👏 👏 Read more ⬇️

Congratulations to Colin Kleanthous and Rob Klose on joining the Fellowship of the Royal Society

The two scientists have been selected for outstanding contributions to their fields

bit.ly

Happy 100th birthday, Sir David Attenborough! 🎂 A legendary broadcaster, natural historian and Clare College alumnus whose voice has inspired generations worldwide for decades. Thank you for a century of curiosity, wonder and unwavering dedication to life on earth.

Very importantly, one of the co-organisers @xrnchew.bsky.social is cycling to the meeting to raise awareness and funds for 'All things small and green' . Please join him or sponsor him! gofund.me/f4068dc3c

Donate to Cycling from Exeter to the 3' end (in Oxford)!, organized by Steven West

I'll be cycling from Exeter to Oxford (about 160 miles/260 km) - hopefully … Steven West needs your support for Cycling from Exeter to the 3' end (in Oxford)!

gofund.me

Only 1 week left to register for the RNA 3' ends processing meeting, come one, get a wiggle on!! meetings.embo.org/event/26-rna3

Looking forward to hosting Iva Tchasovnikarova @oxfordbiochemistry.bsky.social today for a seminar today! Come along to hear about Fluorogenetic interrogation of epigenetic repression 1 pm Dorothy Crowfoot Hodgkin Building - Seminar Room 2 Department of Biochemistry Oxford

Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic

I wrote an essay. It’s about gain-of-function mutations. And penguins. Also ion channels, chihuahuas, the film Alien, recycled cardboard, and the Apollonian mind. Oh, and muffins. Thanks to the editors of #GENETICS @genetics-gsa.bsky.social for letting me take some stylistic liberties. 1/2

Just a quick reminder that the first of these Associate Professorships have a closing date for applications of April the 8th. Get your application in now! Please repost

Rob Klose@robklose.bsky.social · 5mo ago

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

We are looking for a Postdoc to join our lab at @oxfordbiochemistry.bsky.social. This is a dry-lab focused post on the computational analysis of long read single-cell sequencing data to understand the role of transposable elements (TEs) in early development. my.corehr.com/pls/uoxrecru... #TEsky

Another fantastic evening celebrating truly inspirational women at the Suffrage Science Awards in Life Sciences 2026. Read about the awardees and what the nominators - previous recipients - had to say about why they nominated these exceptional women: bit.ly/LifeSciences2026

daylight savings in the USA skipped us forward 1 hour, so we might be starting 1 hour earlier for some. Check your time against 9:00 PDT / 12:00 EDT (instead of PST/EST) to ensure you've got the correct start time for tomorrow!

FragileNucleosome@fnucleosome.bsky.social · 5mo ago

⚡This Wednesday! 🥁We've got two exciting chromatin talks coming up from @almassalha.bsky.social and @carmeloferrai.bsky.social 🐣If you haven't registered for the series, please register and join us: us06web.zoom.us/webinar/regi...

⏰ Calling all chromatin aficionados! We we will be joined by @adelmanlab.bsky.social from @harvardmed.bsky.social for our March 27th webinar 📅 Karen will be sharing her groups work on 'Transcription & RNA Quality Control in Health & Disease' 😷🧬 Register here: us06web.zoom.us/webinar/regi...

meetings.embo.org/event/26-rna3 To all 3' end (and RNA, in general) enthusiasts. I'm organising a great conference in Oxford 7th-11th Sept with @lapassmore.bsky.social and Christine Mayr. The lineup of speakers is brilliant! Registration closes 4th May. Please consider it!

Happy to share our new preprint! 📊 We benchmarked methods for locus-level transposable element quantification in short-read scRNA-seq, using both real datasets and simulations with read-level ground truth. Huge thanks to @catavallejos.bsky.social and @antonio-scialdone.bsky.social! #TEsky

bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · 5mo ago

Benchmarking computational tools for locus-specific analysis of transposable elements in single-cell RNA-seq datasets https://www.biorxiv.org/content/10.64898/2026.02.26.708244v1

Help needed: I know this has been discussed before - what are people doing now that phase lock tubes have disappeared from the market? Is everyone making their own and that's why companies are not selling them anymore? If so, what is the best vaccum grease you would recommend? 🤷‍♀️

Very nice review by @mileshuseyin.bsky.social and colleagues!

Miles Huseyin@mileshuseyin.bsky.social · 6mo ago

I had a lot of fun putting this together with @suminkim.bsky.social and @andersshansen.bsky.social! Glad to have had the chance to work on it!

Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: www.sciencedirect.com/science/arti...