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Jacob Nadel

@nadelneurosci.bsky.social

PhD candidate in the Lerner Lab at Northwestern | Oberlin College ‘19 | Stress, basal ganglia, amygdala, dopamine

12 Posts494 Follower216 Folgt
Dr. Cate Peña@cate-cholamine.bsky.social · 2mo ago

So proud to have “Early-life stress alters H3K4me1 in VTA to prime stress sensitivity” out now in Neuron! This work spanned Many years and Many people contributed. Huge thanks to @hyejaykim.bsky.social, @ja-balouek.bsky.social, Luke Geiger, and Meaghan Creed www.cell.com/neuron/fullt...

Early-life stress alters H3K4me1 in VTA to prime stress sensitivity

Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...

cell.com

Talia Lerner@talialerner.bsky.social · 2mo ago

🚨Happy to share a new preprint from Lerner Lab led by graduate student @nadelneurosci.bsky.social! 🚨 “Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking” This has been a wholly impressive effort by Jacob; summary below 👇 #neuroskyence🧪

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2mo ago

Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking https://www.biorxiv.org/content/10.64898/2026.07.29.741478v1

Christopher Howard@howarddopamine.bsky.social · 2y ago

How quickly can rodents adapt to changes in time durations in their environment? Work from @oberlincollege.bsky.social suggests they can recognize and respond extremely quickly, hinting at a rapid mechanism for learning about time in the brain. link.springer.com/article/10.1...

Rats and mice rapidly update timed behaviors - Animal Cognition

Keeping track of time intervals is a crucial aspect of behavior and cognition. Many theoretical models of how the brain times behavior make predictions for steady-state performance of well-learned int...

link.springer.com

Adam Van Arsdale@apv2600.bsky.social · 2y ago

My feed is overwhelmed with scientists right now calling out the catastrophic consequences of the NIH indirect cost order from last night. If those same people aren't also speaking out against the anti-trans, anti-DEI, anti-immigrant orders...we are lost. The only path forward is solidarity.

Emily Prevost@emilyprevost.bsky.social · 2y ago

Honored to receive first place poster award at #wcbr2025! Thanks to all who stopped by. The poster (and my panel) explored divergent signaling dynamics in VTA dopamine subpopulations, as well as functional roles for glutamate and dopamine in co-transmitting VTA neurons. Stay tuned for more!

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Ashley Holloway@ashleyholloway.bsky.social · 2y ago

Hi #ACNP2024! I'm a postdoc in Reesha Patel's lab at Northwestern, and this is my first in-person ACNP 🎉 I'm presenting a poster on Monday (M157) on VTA 🌟astrocyte 🌟 activity during appetitive and aversive conditioning!

Neuropsychopharmacology@npp-journal.bsky.social · 2y ago

We are officially on the ground in Phoenix so it's time for the #ACNP2024 role call 📣 Introduce yourself, your science, tell us if you're a veteran or first-timer, promote your poster/talk/favorite social - whatever you want, this is your space to say it ⬇️

Jacob Nadel@nadelneurosci.bsky.social · 2y ago

My main postbac project is published! In collaboration with the late great Richard Veech, we tested how ketone-ester enriched chow impacted the progression of motor and dopamine deficits in the MitoPark mouse model. Find out more here! doi.org/10.1111/ejn....

Ketone ester–enriched diet ameliorates motor and dopamine release deficits in MitoPark mice

MitoPark mice, a model of Parkinson's disease, fed a ketone ester–enriched diet had moderate improvements in locomotor performance on open field and rotarod behavioural tasks. This behavioural improv....

doi.org