It’s a real shame that folks with mental illness have to fight not only their symptoms but also concerted efforts to undermine their treatment. 😢 The @nytimes.com mag published a long piece entitled “rethinking adhd”. Here is a 🧵 highlighting its factual & logical errors 1/n

A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄 @theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏 www.biorxiv.org/content/10.1...

A multi-institutional investigation of psilocybin's effects on mouse behavior

Studies reporting novel therapeutic effects of psychedelic drugs are rapidly emerging. However, the reproducibility and reliability of these findings could remain uncertain for years. Here, we impleme...

biorxiv.org

MyVivarium is an #opensource tool for animal colony management. It uses QR codes, IoT sensors, & allows for cloud-based tracking. Read about it in this week's post on OpenBehavior: edspace.american.edu/openbehavior...

One of the NIMH PIs whose name is the termination list: Sooyhun Lee, whose lab just published this beautiful @nature.com paper (that has received too little press because comms at NIH are down). Read! Cite! www.nature.com/articles/s41...

Brain-wide presynaptic networks of functionally distinct cortical neurons - Nature

Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with non-behavio...

nature.com

Jeremy Berg@jeremymberg.bsky.social · last yr.

Compelling pushback from @jmgrohneuro.bsky.social and the Board of Scientific Counselors at the National Institute on Mental Health (NIMH) regarding termination of tenure-track investigators driven by DOGE. 1/2

Check out FlexRig, an open-source platform for decision-making & cognitive flexibility studies. 🐁🧠 Olfactory, auditory, somatosensory cues, & more! Low-cost, fully customizable. #OpenSource #Neuroscience #ResearchTools @tspell.bsky.social edspace.american.edu/openbehavior...

FlexRig

Visit the post for more.

edspace.american.edu

Special shout out this AM to NIH 🧪 grant mgmt specialists, POs, and SROs during this chaotic time - THANK YOU for caring for our grants and uploading scores/summary statements despite the unprecedented challenges you may be facing. You are science warriors and we APPRECIATE & SUPPORT YOU 🫶

Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊 Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs. Paper here 👇 www.nature.com/articles/s41...

Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression - Nature Communications

A challenge in psychiatric drug discovery is to predict the therapeutic potential of a novel compound. Here, the authors show that brain-wide imaging of immediate early gene expression can be used to ...

nature.com

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.

The author’s resolution is both obvious and endogenous

It does matter to continue to try to elicit shame to prevent the 'rhinoceros stampede' from 'destroying the habitat for democracy.' _________________________________________ ¹ Rhinocerization is Hungarian playwright Eugène Ionesco's term for losing your empathy and becoming a nationalist minion.

A wonderful paper from @tonyzador.bsky.social and colleagues: Encoding innate ability through a genomic bottleneck www.pnas.org/doi/10.1073/...

Encoding innate ability through a genomic bottleneck | PNAS

Animals are born with extensive innate behavioral capabilities, which arise from neural circuits encoded in the genome. However, the information ca...

pnas.org

There are many nuances regarding the structural neural plasticity associated with antidepressant drugs. 💊🧠 We share our thoughts here in a Nature Reviews Neuroscience article, led by Clara Liao with co-authors from Conor Liston’s lab at Weill Cornell. www.nature.com/articles/s41...

Did you see this coming? Abstract categorization in a so-called sensorimotor midbrain area. Primate superior colliculus is causally engaged in abstract higher-order cognition www.nature.com/articles/s41... #neuroscience

Primate superior colliculus is causally engaged in abstract higher-order cognition - Nature Neuroscience

Neuronal recordings show that primate superior colliculus encodes learned abstract visual categories. The authors demonstrate that it plays a causal role in categorization behavior, independent of its...

nature.com

New Paper Alert! 🚨 "Testing methods of neural systems understanding" by me & David Bau is online now: https://www.sciencedirect.com/science/article/pii/S1389041723000906 We argue for an explicit test of the tools used to understand 'neural systems', i.e. brains and artificial neural networks.

New wave research? We’ve got some ‘splining to do! 〰 These oscillations are high-frequency: 130-160 Hz, at the peaks of theta rhythms in the retrosplenial cortex (part of the brain essential for successful navigation). https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00822-1 🧪 #neuroscience

Micah G. Allen@micahgallen.com · 3y ago

Hey #neuroskyence and #psychscisky - great to see so many familiar faces joining! Why don’t we all share a post about our most recent paper or project to liven things up and complement all these nice introductions? 😎🤩

hi #neuroskyence, I’m emma! 👋🧠 I work on brain-machine interfaces in industry, first at neuralink (I wrote most of the software for the pig and monkey demos!), and more recently as cofounder + software lead at science corp. always looking for more neuro + bci friends, ❤️ if that’s you! 🧪