🧠 New paper accepted in Neuropsychologia! Dysfunctional neural processing of object-related speech in schizophrenia spectrum disorders — and a potential compensatory role of congruent tool-use gestures? Great work led by Katrin Leinweber! #Schizophrenia #fMRI #Gesture doi.org/10.1016/j.ne...
📢 Wir suchen Verstärkung! Neue Promotionsstelle (3 Jahre, 65 %, E13) in unserer Arbeitsgruppe zu affektiven & Angststörungen, Erwartungen und Lernen. 🧠 fMRT & EEG 🤝 SFB/TRR 393 + DFG-Projekt Angststörungen 📅 Bewerbung bis 27.09.2026 stellenangebote.uni-marburg.de/jobposting/4... Gerne teilen!
Qualifizierungsstelle mit dem Ziel der Promotion
stellenangebote.uni-marburg.de
Expectations matter—not only for how we act, but also for mental health. 🧠 Our new study shows that negative expectations in major depression are linked to brain structure and predict illness course over two years—complementing our recent #ExSA framework. doi.org/10.1016/j.ja... #Expectations
Redirecting
doi.org
New: Prefer listening over reading? This 8-minute podcast provides an accessible overview of the ExSA framework and the main ideas presented in the article: tnm-lab.com/episode/podc...
Podcast: The Invisible Architects of Our Actions
How do expectations shape our actions? This podcast provides an accessible introduction to the ExSA (Expectations Shape Action) framework, which explains how expectations guide action from decision…
tnm-lab.com
Paper out - big congrats to Dahna Choi! How #empathy & #perspectivetaking relate to #depression, specifically disease severity @trr393.bsky.social @katfoerster.bsky.social @lisaleehr.bsky.social @straubeb.bsky.social @tudresden.bsky.social @kanskelab.bsky.social doi.org/10.1002/jclp...
When Being Social Is Costly: Empathy's Role for Risk States, Acute Symptoms, and Cumulative Disease Severity of Depression
Objectives Patients with major depressive disorder (MDD) frequently report burdensome interpersonal difficulties and altered empathy and perspective-taking. Previous findings on binary comparisons b.....
doi.org
Now available in Trends Open: How do expectations shape actions? I introduce the ExSA framework, integrating perspectives from motor control, decision-making, predictive processing, and clinical neuroscience Read here: www.cell.com/trends-open/... #Psychology #MotorControl #PredictiveProcessing
How does attention shape what we perceive—and does this differ in schizophrenia spectrum disorders? Here our new findings: rdcu.be/fr3sm #Schizophrenia #Psychiatry #Neuroscience #Attention #Perception #CognitiveNeuroscience
The role of attention in perceptual biases in patients with schizophrenia spectrum disorder and healthy controls
rdcu.be
🚨 Permanent position! theadaptivemind-excellencecluster.de is looking for a managing director of our new outreach hub. This is an unlimited time position at an E13 paygrade (~postdoc level) Apply by May 31st 👉 www.career.tu-darmstadt.de/tu-darmstadt... Please share widely 🙏
career.tu-darmstadt.de
📍DYNAMIC Symposium at the Psychology and Brain Conference 2026 Researchers from the LOEWE Center DYNAMIC attended the Psychology and Brain Conference, which took place in Heidelberg from June 3 to 6. ➡️ Read more: www.dynamic-center.net/announce-202...
DYNAMIC Symposium at the Psychology and Brain Conference 2026
Participation from LOEWE-DYNAMIC Researchers in the Psychology and Brain Conference 2026
dynamic-center.net
Very happy that our manuscript with my brilliant collaborators @jamestrujillo.bsky.social and @straubeb.bsky.social is now published @jneurolang.bsky.social. 🥳🥳🥳 Interested in gesture, discourse, fMRI, prediction, computational modeling? This is the paper for you 👇 doi.org/10.1162/NOL....
Discourse context and co-speech gestures jointly shape hierarchical prediction during the processing of a multimodal narrative
Abstract. Understanding one another in daily communication depends on predicting language from prior discourse context and visual signals, such as co-speech gestures. However, it remains unclear how d...
doi.org
When listening to a story, earlier parts of the story (context) and the speaker's gestures help us predict and understand what they are saying. In a new preprint we show context and gestures have a push-pull synergy on neural response to linguistic information 👇🧵
New paper in Scientific Reports: Using HRF temporal and dispersion derivatives, we show altered preparatory neural timing in SSD, particularly during self-generated action processing. www.nature.com/articles/s41... #Schizophrenia #fMRI #SenseOfAgency
Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study - Scientific Reports
Scientific Reports - Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study
nature.com
Toller Artikel @zeit.de über Placebo-Effekte @sfb-trr-289.bsky.social. Toll auf den Punkt gebracht, dass der Placebo-Effekt ein klinisch extremlich nützlicher Mechanismus ist, der von Medizin und Pharma als Freund, nicht als Feind, betrachtet werden sollte. www.zeit.de/gesundheit/2...
Placebo-Forschung: Placebos sind der Schlüssel zu einer menschlichen Medizin
Wir haben eine Apotheke in uns, die wir kostenlos nutzen können. Der Placebo-Effekt ist so stark, dass wir eigentlich das gesamte Gesundheitswesen umkrempeln müssten.
zeit.de
New manuscript: From Expectation to Learning: A Mediational Model of Exposure Therapy Outcome in Anxiety Disorders We propose a hierarchical pathway: generalized expectations → treatment-specific expectations → learning rate during exposure → clinical outcome. doi.org/10.1159/0005... #Expectation
From Expectation to Learning: A Mediational Model of Exposure Therapy Outcome in Anxiety Disorders
Abstract. Introduction: Negative expectations about treatment outcomes are associated with poorer recovery in anxiety disorders. However, it remains unclear whether (1) patients’ expectations about how effective the treatment will be (treatment-specific expectations) mediate the link between generalized negative expectations (i.e. unspecific pessimistic beliefs) and treatment outcomes, and (2) these expectations affect outcomes via the learning rate during exposure therapy, that is, the extent to which patients update their fear-related beliefs based on corrective experiences. Since treatment-specific expectations may be more modifiable, clarifying these mechanisms could improve interventions. This study investigated whether treatment-specific expectations and learning rate mediate the effect of generalized negative expectations on treatment outcomes. Methods: Data from 605 patients with various anxiety disorders undergoing 12 sessions of manualized exposure therapy were analyzed. Generalized negative expectations at baseline (session 0) were hypothesized to predict treatment outcomes (i.e., symptom severity at post treatment) via expectations about treatment success measured at session 4 and learning rate during exposure. Depression and anxiety at baseline were covariates. Mediation analyses were conducted using the PROCESS macro with bootstrap confidence intervals. Results: Generalized negative expectations predicted poorer treatment outcomes (higher symptom severity), mediated by lower expectations about treatment success (β = 0.0375; 95% CI: 0.0088–0.0730). A sequential mediation via these treatment-specific expectations and learning rate was also significant (β = 0.0059; 95% CI: 0.0008–0.0134), even after accounting for baseline symptom levels (R² = 0.3375). Conclusion: Targeting both generalized and treatment-specific expectations early in treatment may enhance exposure-based learning and improve clinical outcomes in anxiety disorders.
doi.org
Our special issue on the CRC/TRR 393 "Trajectories of Affective Disorders" is out. Find out all about the project here www.springermedizin.de/der-nervenar... @trr393.bsky.social @tudresden.bsky.social @uni-muenster.de @unimarburg.bsky.social
Why are tactile sensations suppressed during movements? In our new preprint, we explain this as optimal integration of sensory signals with an internal model. Work led by @fatatai.bsky.social with Dimitris Voudouris, Katja Fiehler and @c-rothkopf.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
Why is touch perceived as weaker during movement? In our new preprint 📝, we examine tactile suppression during reaching. Using optimal control theory, we show that tactile suppression reflects dynamic, uncertainty-dependent integration of forward model predictions and sensory feedback.
How is genetic risk for inflammation linked to mental disorders? Our new study applies transdiagnostic network analysis to uncover symptom-level associations beyond categorical diagnoses. www.sciencedirect.com/science/arti...
Genetic predisposition to inflammation and psychopathology: A transdiagnostic network analysis
Although low-grade inflammatory processes have traditionally been studied in affective disorders, they are increasingly recognized as relevant across …
sciencedirect.com
I’m excited to announce that Bielefeld will soon (in 2026) be home to a research-dedicated 3-T MRI The scanner will be run as a central research core facility, and we’re seeking a scientific leader (TV-L E15, permanent) to help build and shape it. MR physicist ads to follow. tinyurl.com/mryhaxed
Leiter*in (m/w/d) der zentralen Core Facility MR I...
Mit der Entwicklung der zentralen, fakultätsübergreifenden Core Facility MR Imaging baut die Universität Bielefeld unter Beteiligung der Naturwisse...
uni-bielefeld.hr4you.org
"deepmriprep: VBM preprocessing via deep neural networks" is published in Nature Computational Science 🧠💻 🔗 Paper: rdcu.be/e1t4N VBM preprocessing in ~10 seconds per #brain image 🚀 🔗 GitHub: github.com/wwu-mmll/deepm… Install via "pip install deepmriprep"
📢Out now! @codingfisch.bsky.social and colleagues present deepmriprep, a tool that leverages neural networks to enable 37x faster Voxel-based Morphometry preprocessing of MRI data than existing methods. www.nature.com/articles/s43... #compneurosky
deepmriprep: voxel-based morphometry preprocessing via deep neural networks - Nature Computational Science
deepmriprep leverages neural networks to enable voxel-based morphometry preprocessing of MRI data that is 37× faster than existing methods while achieving comparable accuracy in segmentation, registra...
nature.com
New fMRI evidence shows altered neural dynamics in schizophrenia spectrum disorders: temporal recalibration of action-outcome predictions engages the middle frontal gyrus and cerebellum differently in patients vs controls. www.nature.com/articles/s41...
Client Challenge
nature.com
New evidence challenges a usual assumption of exposure therapy: instructed increases in fear activation during exposure did not enhance treatment outcomes for anxiety disorders (e.g., social anxiety/panic) www.sciencedirect.com/science/arti...
Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia
The efficacy of exposure-based cognitive behavioral therapy (eCBT) for panic disorder and agoraphobia (PD/AG) is well established, but the mechanisms …
sciencedirect.com
Introduction to the interventions tested in our @trr393.bsky.social consortium to improve #depression and #bipolardisorder Big thanks to @lisaleehr.bsky.social! @unimarburg.bsky.social @tudresden.bsky.social @uni-muenster.de @dfg.de @dgps.bsky.social link.springer.com/article/10.1...
What to target? Interventions to modulate key mechanisms underlying the trajectories of affective disorders in the transregional Collaborative Research Center 393 - Der Nervenarzt
Background Affective disorders are associated with an enormous disease burden, necessitating research on the mechanisms of effective treatments. Objectives This article introduces the intervention pro...
link.springer.com
Let's meet at the #DGPPN! Our members are happy to chat with you at our info desk in the exhibition hall, right across the main entrance - stop by to get to know the people behind the hashtag #SFBTRR393 👥 (also: we have sweets 🤭) #DGPPN2025 #DGPPNKongress
📄 New study published: Exploring the sustainability of treatment success over five years – key insights for clinical practice! 🔍 Read more here: doi.org/10.1159/0005... #Medicine #TreatmentSuccess #LongTermStudy #Research #Sustainability
Sustainability of treatment success five years after exposure-based cognitive-behavioral therapy for anxiety disorders
Abstract. Introduction: Achieving sustainable success in the treatment of anxiety disorders remains a central objective in mental health care. Although research has demonstrated the short-term efficac...
doi.org
Last week, 130 researchers of the #SFBTRR393 & invited guests gathered at Kulturrathaus Dresden for an inspiring retreat. 4 days of sharing recent results, discussing new directions, and strengthening collaborations across sites. More & more difficult to get everyone into one photo, but we managed!
During last week's retreat, we awarded #posterprizes to the best 3 of ~70 excellent #ECR posters. 🎉 Congratulations to winners Vera Ludwig, Alina Nostadt, Claudia Förster Ribet, Tung Anh Nguyen & Theresa Kolb - thank you to all ECRs for presenting your research and engaging in lively discussions!
🧠 Our CRC/TRR 393 consortium outlines key mechanisms of affective disorders — focusing on emotion regulation, expectation, social cognition, and cognitive-behavioral rhythms. Read here 👉 doi.org/10.1007/s001... @kanske.bsky.social @markuswohr.bsky.social @lisaleehr.bsky.social @trr393.bsky.social
Key mechanisms of affective disorders - Der Nervenarzt
Background Although affective disorders are a major driver of disability worldwide, there is a lack of understanding of the mechanisms and modulating factors involved in the long-term disease trajecto...
doi.org
📣 The ENIGMA study “Regional brain morphology and current antidepressant use” explores how antidepressant medication correlates with structural brain differences in Major Depressive Disorder across age and sex, drawing on data from 32 international cohorts. 🧠 🔗 Read it here: doi.org/10.1038/s413...
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group - Molecular Psychiatry
Molecular Psychiatry - Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group
doi.org