When Being Social Is Costly: Empathy's Role for Risk States, Acute Symptoms, and Cumulative Disease Severity of Depression

Objectives Patients with major depressive disorder (MDD) frequently report burdensome interpersonal difficulties and altered empathy and perspective-taking. Previous findings on binary comparisons b.....

doi.org

The role of attention in perceptual biases in patients with schizophrenia spectrum disorder and healthy controls

rdcu.be

career.tu-darmstadt.de

DYNAMIC Symposium at the Psychology and Brain Conference 2026

Participation from LOEWE-DYNAMIC Researchers in the Psychology and Brain Conference 2026

dynamic-center.net

Discourse context and co-speech gestures jointly shape hierarchical prediction during the processing of a multimodal narrative

Abstract. Understanding one another in daily communication depends on predicting language from prior discourse context and visual signals, such as co-speech gestures. However, it remains unclear how d...

doi.org

Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study - Scientific Reports

Scientific Reports - Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study

nature.com

Placebo-Forschung: Placebos sind der Schlüssel zu einer menschlichen Medizin

Wir haben eine Apotheke in uns, die wir kostenlos nutzen können. Der Placebo-Effekt ist so stark, dass wir eigentlich das gesamte Gesundheitswesen umkrempeln müssten.

zeit.de

From Expectation to Learning: A Mediational Model of Exposure Therapy Outcome in Anxiety Disorders

Abstract. Introduction: Negative expectations about treatment outcomes are associated with poorer recovery in anxiety disorders. However, it remains unclear whether (1) patients’ expectations about how effective the treatment will be (treatment-specific expectations) mediate the link between generalized negative expectations (i.e. unspecific pessimistic beliefs) and treatment outcomes, and (2) these expectations affect outcomes via the learning rate during exposure therapy, that is, the extent to which patients update their fear-related beliefs based on corrective experiences. Since treatment-specific expectations may be more modifiable, clarifying these mechanisms could improve interventions. This study investigated whether treatment-specific expectations and learning rate mediate the effect of generalized negative expectations on treatment outcomes. Methods: Data from 605 patients with various anxiety disorders undergoing 12 sessions of manualized exposure therapy were analyzed. Generalized negative expectations at baseline (session 0) were hypothesized to predict treatment outcomes (i.e., symptom severity at post treatment) via expectations about treatment success measured at session 4 and learning rate during exposure. Depression and anxiety at baseline were covariates. Mediation analyses were conducted using the PROCESS macro with bootstrap confidence intervals. Results: Generalized negative expectations predicted poorer treatment outcomes (higher symptom severity), mediated by lower expectations about treatment success (β = 0.0375; 95% CI: 0.0088–0.0730). A sequential mediation via these treatment-specific expectations and learning rate was also significant (β = 0.0059; 95% CI: 0.0008–0.0134), even after accounting for baseline symptom levels (R² = 0.3375). Conclusion: Targeting both generalized and treatment-specific expectations early in treatment may enhance exposure-based learning and improve clinical outcomes in anxiety disorders.

doi.org

biorxiv.org

Genetic predisposition to inflammation and psychopathology: A transdiagnostic network analysis

Although low-grade inflammatory processes have traditionally been studied in affective disorders, they are increasingly recognized as relevant across …

sciencedirect.com

Leiter*in (m/w/d) der zentralen Core Facility MR I...

Mit der Entwicklung der zentralen, fakultätsübergreifenden Core Facility MR Imaging baut die Universität Bielefeld unter Beteiligung der Naturwisse...

uni-bielefeld.hr4you.org

deepmriprep: voxel-based morphometry preprocessing via deep neural networks - Nature Computational Science

deepmriprep leverages neural networks to enable voxel-based morphometry preprocessing of MRI data that is 37× faster than existing methods while achieving comparable accuracy in segmentation, registra...

nature.com

Client Challenge

nature.com

Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia

The efficacy of exposure-based cognitive behavioral therapy (eCBT) for panic disorder and agoraphobia (PD/AG) is well established, but the mechanisms …

sciencedirect.com

What to target? Interventions to modulate key mechanisms underlying the trajectories of affective disorders in the transregional Collaborative Research Center 393 - Der Nervenarzt

Background Affective disorders are associated with an enormous disease burden, necessitating research on the mechanisms of effective treatments. Objectives This article introduces the intervention pro...

link.springer.com

Sustainability of treatment success five years after exposure-based cognitive-behavioral therapy for anxiety disorders

Abstract. Introduction: Achieving sustainable success in the treatment of anxiety disorders remains a central objective in mental health care. Although research has demonstrated the short-term efficac...

doi.org

Key mechanisms of affective disorders - Der Nervenarzt

Background Although affective disorders are a major driver of disability worldwide, there is a lack of understanding of the mechanisms and modulating factors involved in the long-term disease trajecto...

doi.org

Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group - Molecular Psychiatry

Molecular Psychiatry - Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group

doi.org

Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium - Translational Psychiatry

Translational Psychiatry - Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium

nature.com

Redirecting

doi.org

Redirecting

doi.org