📢 Calling all senior neuro postdocs: SYNAPSES brings postdocs from around the world to Yale to share their work during an in-person symposium on October 22, 2026. Apply today! Deadline Sept 3. medicine.yale.edu/neuroscience...

📢 Attention Recent Graduates 📢 I’m hiring a Postgraduate Research Associate to join my growing team at Yale! If you’re passionate about RNA biology/Gene Regulation and are looking to gain hand-on research experience before graduate school, please consider applying! postdocs.yale.edu/posts/2026-0...

Summer plans: start with the RNA Center! The academic year is wrapping up; let’s celebrate together at the RNA Center’s Midsummer RNA Dream social. For soccer fans: we’ll be screening the World Cup match. Jerseys encouraged Details in the flyer and website medicine.yale.edu/event/rna-ce...

Congrats to our postdoc Katie Copley on another terrific publication from her PhD work @upenn.edu with Shorter and Barmada labs! @yaleneuro.bsky.social @yalerna.bsky.social www.science.org/doi/10.1126/...

Isoform-specific steric zippers drive aberrant assembly and mislocalization of shortened TDP-43

The sequence-encoded determinants underlying aberrant sTDP-43 behavior are defined, revealing therapeutic strategies for ALS.

science.org

Two new preprints featuring work from @ryanymuller.bsky.social on PABPC biology! With important contributions from @eugenevalkov.bsky.social, Tanner Myers, and @kxwang.bsky.social

The molecular determinants of PABPC-mediated deadenylation rate

Deadenylation, the enzymatic shortening of the poly(A) tail, is typically the first committed step of mRNA decay. Deadenylation rates span nearly a 1000-fold range between transcripts and are governed...

biorxiv.org

It’s time for the final RNA Club of the academic year Tuesday, June 9 9:00 AM Hope 103, Yale School of Medicine Featuring great talks by the Lu & Gerstein Lab and the Simon Lab. Details in the flyer

Check out this Q&A by @alstdi.bsky.social highlighting Dr. Katie Copley, a Corsalex Postdoc Fellow in our lab @yaleneuro.bsky.social @yalerna.bsky.social ! The Corsalex Postdoctoral Fellowship program is now open for application: www.corsalex.com/corsalex-fel...

"I always wanted to be a scientist." Pietro De Camilli’s journey from curious observation of nature as a child to understanding the molecular machinery of the brain has consistently been driven by an unwavering commitment to understanding life. @pdc-lab.bsky.social

Tending The Frontier: Pietro De Camilli and the Cell Biology of Neurons

Pietro De Camilli always wanted to be a scientist. He has spent his career bridging cell biology and neuroscience.

medicine.yale.edu

Congratulations to our @yaleneuro.bsky.social INP student Ata Isiktas for being selected as one of the ✨Rising Stars in Neuroscience✨ and to give a research talk @uuneurobiology.bsky.social @yalerna.bsky.social

Check out the phenomenal PhD work by Katie Copley, a current postdoc in our lab @yaleneuro.bsky.social @yalerna.bsky.social. www.science.org/doi/10.1126/...

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how sho...

science.org

🆕 review with @jpunfried.bsky.social out in Nature SMB. Direct roles of lncRNAs in transcriptional activation. What do we understand about how lncRNAs lure Pol2 and set the stage for RNA production, and what do we still miss? www.nature.com/articles/s41...

Direct roles of long non-coding RNAs in transcription activation - Nature Structural & Molecular Biology

This Review discusses how long noncoding RNAs (lncRNAs) control transcription activation by RNA polymerase II, including how they are produced at active enhancers or chromatin-domain boundaries and ac...

nature.com

A full house of audience @yalerna.bsky.social learning from Dr. Xiang-Dong Fu from Westlake University about his latest work on transcriptional regulation in aging. He spoke separately with our trainees about his 40-year scientific career in the US and China. Thank you for visiting us!

We bid farewell to @yaleneuro.bsky.social graduate Suzhou Yang, who discovered C9orf72 RNA cryptic splicing in ALS-FTD and will soon move to UCLA to start postdoc training with William Yang working on Huntington's disease. Can't wait to hear about your future successes! @yalerna.bsky.social

Thomas A. Steitz Lecture Series by @yalembb.bsky.social Dr. Rachel Green, “ZAK activation on the colliding ribosome”, hosted by Dr. Yong Xiong Monday, April 20 | 4:00 PM 📍O.C. Marsh Lecture Hall, Yale Science Building Open to Yale and affiliated institutions. Details in the flyer below

Our work investigating mRNA 3' UTRs that trigger target-directed miRNA degradation is now published! genesdev.cshlp.org/content/earl...

David Bartel's Lab@bartellab.bsky.social · 9mo ago

Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)

New @yalembb.bsky.social student Han Yin joins the lab for PhD thesis research. Han received his BS in Biology from Peking University @pku1898.bsky.social, where he worked on membrane protein structure, electrophysiology, and of course, RNA. Welcome, Han! @yaleneuro.bsky.social @yalerna.bsky.social

Our work on the E3 ligase mechanism of target-directed microRNA degradation is now published! Amazing collaboration with Brenda Schulman’s lab led by @jakobfarnung.bsky.social and @elenaslo.bsky.social, with special thanks to @wyppeter.bsky.social, Lianne Blodgett, and Daniel Lin! tinyurl.com/Z8TDMD

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation - Nature

Target-directed microRNA degradation is driven by the atypical ZSWIM8–CUL3 E3 ubiquitin ligase that uses a two-RNA-factor authentication mechanism to specifically recognize AGO–miRNA–trigger...

tinyurl.com

David Bartel's Lab@bartellab.bsky.social · 7mo ago

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

We are recruiting a post-bac researcher to join our lab in Yale MCDB! Ideal for a recent college grad looking to get in-depth research experience and mentoring in genetics & cell/molecular biology, working on exciting cilia-related projects. Details: breslowlab.yale.edu/news/post-gr...

Congratulations to The Brain Prize winners Prof. David Ginty (Harvard Medical School, US) and Patrik Ernfors (Karolinska Institutet, SE) for their pioneering work on how the nervous system detects and processes touch and pain: https://brainprize.org/winners/touch-and-pain-2026 The Brain Prize HHMI

RNA Club | March 2026 Come support our trainees and engage in discussion across RNA disciplines 📅 Tuesday, March 10 ⏰ 9:00 AM 📍 Bass 305, Science Hill Coffee & bagels provided Open to Yale and affiliated institutions

Congratulations to Dr. Lianhuan Wei in the lab for winning a poster award at the Gordon conference on FTD and related dementias! @yaleneuro.bsky.social @yalerna.bsky.social

Biochemist/molecular biologist Joan Steitz was born #OTD in 1941. She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM

Check our latest collaboration with the Kleaveland Lab (kleavelandlab.org), led by Joanna Stefano and Lara Elcavage: academic.oup.com/nar/article/... (1/2)

Excited to publish our work on how mutations in the muscle-specific ribosomal protein RPL3L drive severe heart disease. This is Part I of a larger body of work led by Michael - stay tuned for Part II on how specialized ribosomes function in normal physiology www.nature.com/articles/s44...

Michael Murphy@mmurphyrna.bsky.social · 7mo ago

Thrilled to share our research on how mutations in the muscle-specific ribosomal protein RPL3L, a paralog of RPL3, cause a rare infant heart disease. Hotspot mutations are both proteotoxic and induce unproductive splicing in RPL3 mRNA, preventing phenotypic rescue. rdcu.be/eYkC7

The Wu Tsai Institute at Yale University is hiring! Two faculty searches are now open for neurocomputation and neurodevelopment. If you are at #SfN25, visit booth #3724 to learn more. wti.yale.edu/opportunities #KnowTogether #ScienceAtYale

New article @natneuro.nature.com by @yaleneuro.bsky.social Suzhou Yang & @kavliatyale.bsky.social Postdoc Fellow @zhenlei.bsky.social, highlighting studies by @frattalab.bsky.social Gitler & La Spada labs on the role of TDP-43 on mRNA 3' end in ALS @yalerna.bsky.social www.nature.com/articles/s41...

TDP-43 loss brings RNA to a twist ending - Nature Neuroscience

In amyotrophic lateral sclerosis (ALS), nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 cause widespread dysregulation of mRNA splicing. Two recent studies have now rev...

nature.com

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins

Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

biorxiv.org

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

mRNA poly(A)-tail length is a battleground for coronavirus–host competition

Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...

biorxiv.org

I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n unc.peopleadmin.com/postings/307...

Excited to see this beautiful art, commissioned from the Chinese artist 懒云居画 (@subaiweipainting on Instagram), on this month's cover of Nature Neuroscience! @natneuro.nature.com @yaleneuro.bsky.social @yalerna.bsky.social @kavliatyale.bsky.social @wutsaiyale.bsky.social

Nature Neuroscience@natneuro.nature.com · 10mo ago

Our October issue is now live! www.nature.com/neuro/volume...