While we’ve heard that watching cell blebs (like watching larva lamps) can be relaxing, we think that @ankita13jha.bsky.social’s talk from our #CellMigration webinar will leave you feeling excited about #science & running to your #microscope! Full video @ focalplane.biologists.com/2026/09/25/f...

Remodeling of cholesterol metabolism in melanoma progression regulates nuclear membrane mechanics. https://www.biorxiv.org/content/10.64898/2026.09.25.754527v1

Excited to share that Saket Bagde @saketbagde.bsky.social and I @junzhe28.bsky.social are chairing the 2027 Fibronectin, Integrins & Related Molecules GRS in Ventura, CA, 6-7 Feb 2027! Theme: The 4D Matrisome: Integrating Architecture & Dynamics from Morphogenesis to Disease. Applications are OPEN!

1/5 🎉 Finally, the results of my main postdoctoral project are out in @natcomms.nature.com! Adhesion-derived condensates control component availability to regulate adhesion dynamics bit.ly/4y9E8Xr Also excited to see the paper highlighted in Nat Comms Editors’ Highlights 🥳 bit.ly/44n4O9i

Excited to share our new paper, now published in Nature Cell Biology! 🎉 We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces? www.nature.com/articles/s41556-026-01981-1

CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

nature.com

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com : www.nature.com/articles/s41...

What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity! www.nature.com/articles/s41...

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials

Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

nature.com

I am very excited to share this preprint which has been my main postdoc project! We identified leupaxin as a negative regulator of durotaxis via paxillin-FAK inhibition in MDA-MB-231 brain and bone tropic metastatic variants. www.biorxiv.org/content/10.6...

Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships to join our friendly & collaborative environment, in areas related to gene expression, mechanistic cell biology & cancer biology. For more info 👇 sheffield.ac.uk/biosciences/...

🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs). Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬 Details in thread 🧵👇 #ScienceSky #Postdoc #AcademicJobs Please RT🫶

CELL MIGRATION LAB

We study cell migration in health and disease

cellmig.org

Postdocs wanted - Please spread the word! We are looking for one bioinformatician and 1-2 cell biologists with different expertise! See the job ad below for more information and links to the job descriptions!

Delighted to share the latest paper from the lab "Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers" Amazing work driven by @follainga.bsky.social with contributions from many. link.springer.com/article/10.1...

Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers - The EMBO Journal

The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an i...

link.springer.com

1/5: New preprint: Cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1... Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.

Cytokines control the physical state of immune tissue

Unlike most solid-like tissues, immune tissue is protean and reconfigurable—its component cells can patrol vast territories, find rare cellular partners, and dynamically self-organize into functional ...

biorxiv.org

- A postdoc to work on cancer extravasation (4-year project). - A postdoc help in completing Filopodia-related lab projects (2-year). - Multiple Marie Curie postdoc positions that will open in the fall. - We will open a 5-year position to cover my teaching (70% research and 30% teaching).

Guillaume Jacquemet@guijacquemet.bsky.social · last yr.

Are you looking for a postdoc? I will be looking for 2-4 people after the summer to join the lab !! Do not hesitate to reach out and disseminate !!

🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇

Cassie Clarke@cassiejclarke.bsky.social · last yr.

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Our new preprint is out! Led by @stefanosala89.bsky.social sky.social we investigate the difference between molecular tension sensing and global tension on the focal adhesion. Follow along for a thread of our findings: www.biorxiv.org/content/10.1...

LIM Domain Proteins link molecular and global tension by recognizing strained actin in adhesions

Mechanotransduction is fundamental to cell signaling and depends on force-sensitive adhesion proteins. How these proteins differentiate and integrate their responses to tension remains an open questio...

biorxiv.org

Latest from Ivaska Lab ▶️ Niklas Jäntti et al delve deep into the roles of EPLINα/β on integrin trafficking and breast cancer outcomes! Congratulations to all the authors! Check the paper out here: www.sciencedirect.com/science/arti...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

sciencedirect.com

Are you looking for a postdoc? I will be looking for 2-4 people after the summer to join the lab !! Do not hesitate to reach out and disseminate !!

1/ Beyond thrilled to see my #PhD work now published in @jcb.org A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados

Journal of Cell Biology@jcb.org · last yr.

@gounismichalis.bsky.social‬ et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...

In a new study led by InFLAMES PI Professor Johanna Ivaska and Dr James Conway have developed a new fluorescent probe to visualise signaling dynamics in moving cancer cells which they used to uncover a new therapeutic possibility for limiting breast cancer spread. #Illusia @ivaskalab.bsky.social

New visualisation tool helps researchers to target breast cancer dissemination - InFLAMES Research Flagship

Cancer cell movement during metastasis is a dynamic process regulated by several different signals. However, the way cells receive, process and respond to these signals has been extremely hard to dete...

inflames.utu.fi

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation! Read more at: www.nature.com/articles/s41...

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology

Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...

nature.com

Excited to share our recently published study on how DNA secretion in neutrophils modulates their inflammatory response spearheaded by @sbarya.bsky.social Thanks to all our collaborators and contributors for their help getting this story to press. 👏👏 www.nature.com/articles/s41...

Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation - Nature Cell Biology

Arya et al. report that migrating neutrophils resolve acute inflammation by releasing exosomes associated with nuclear DNA. This process is distinct from the release of neutrophil extracellular traps,...

nature.com

Paljon onnea Suomen tiedepalkinnosta, @johannaivaska.bsky.social Professorin viesti päättäjille: "Minä toivoisin, että Suomen valtiovalta ja poliitikot ymmärtäisivät, että pienessä maassa perustutkimus on se ainoa tapa, millä niitä paljon puhuttuja innovaatioita saadaan." www.ts.fi/uutiset/6665...

Suomen tiedepalkinto turkulaiselle syöpätutkijalle

Professori Johanna Ivaska pitää syöpää erityisen kiehtovana tutkimuskohteena ja innostuu siitä yhä uudelleen.

ts.fi

Here we share our opinions on "Practical considerations for data exploration in quantitative cell biology" journals.biologists.com/jcs/article/... Joanna, Hanna and I worked quite a bit on this piece and I hope you find it useful Many thanks to @jcellsci.bsky.social for publishing it

Practical considerations for data exploration in quantitative cell biology

Summary: We present practical guidelines for data exploration in quantitative cell biology that are designed to help yield reliable conclusions and promote a collaborative, transparent approach to dat...

journals.biologists.com

We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️ ats.talentadore.com/apply/vaitos... 📸 @oonapaavolainen.bsky.social

Looking for EGFR shrna plasmid urgently if someone has it🙏 if you could please check your connections it would be great as well! Thank you

As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration www.biorxiv.org/content/10.1...

CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration

Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...

biorxiv.org

🚨 new preprint 🚨 Here we report that deleting the Septin aspB results in cidal activity of the static anti cell wall drug Caspofungin. This wasn’t only in vitro as 🐭 infected with the mutant and treated had 70% survival compared to 30% of the wild-type 1/2

Deletion of core septin gene aspB in Aspergillus fumigatus results in fungicidal activity of caspofungin

Septins are a family of GTP-binding proteins found in many eukaryotic lineages. Although highly conserved throughout many eukaryotes, their functions vary across species. In Aspergillus fumigatus, the...

biorxiv.org

I am very excited to (delayed) share our preprint which has been led by Kabilan Sakthivel on mechanisms by which ECM stiffening of normal 3D tissues in their native environment drives invasive phenotypes www.biorxiv.org/content/10.1...

β1 Integrin–FAK–Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium

Stiffening of tissue is a hallmark of cancer progression, driving invasive phenotypes through complex interactions between cells and their extracellular matrix (ECM). However, the mechanisms linking m...

biorxiv.org