New paper alert! Michal Dibus and team show tensin-1 forms reversible condensates that act as reservoirs for adhesion proteins, tuning adhesion turnover and cell migration - a cool new role for phase separation in cell adhesion dynamics! Congratulations to the team 🎉! Paper here: bit.ly/4y9E8Xr

Michal Dibus@midibu.bsky.social · 4w ago

1/5 🎉 Finally, the results of my main postdoctoral project are out in @natcomms.nature.com! Adhesion-derived condensates control component availability to regulate adhesion dynamics bit.ly/4y9E8Xr Also excited to see the paper highlighted in Nat Comms Editors’ Highlights 🥳 bit.ly/44n4O9i

I'm grateful to have had the opportunity to give my little contribution to this great story! Check it out to see what happens to vocal fold cancer cells under vibrations 🎶

Johanna Ivaska@johannaivaska.bsky.social · 6mo ago

What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity! www.nature.com/articles/s41...

Review alert! Our new review titled 'The dynamic tumor extracellular matrix: Biophysical cues, cellular crosstalk, and disease progression,' is now online! Congrats to all the authors! Link: tinyurl.com/bdh6zzzp

The dynamic tumor extracellular matrix: Biophysical cues, cellular crosstalk, and disease progression

The interplay between diverse cell types and their extracellular matrix (ECM) is fundamental for multicellular life. The ECM is a complex meshwork of …

tinyurl.com

I am very excited to share this preprint which has been my main postdoc project! We identified leupaxin as a negative regulator of durotaxis via paxillin-FAK inhibition in MDA-MB-231 brain and bone tropic metastatic variants. www.biorxiv.org/content/10.6...

Postdocs wanted - Please spread the word! We are looking for one bioinformatician and 1-2 cell biologists with different expertise! See the job ad below for more information and links to the job descriptions!

Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...

I am super happy to see this published in @jcb.org ! If you are interested in cell adhesion and trafficking go have a look !

Ivaska Lab@ivaskalab.bsky.social · 8mo ago

We are very happy to share our latest work exploring the role of newly synthetized integrin-α5 using RUSH. We found that a subset goes to the PM via unconventional secretion! Big thanks to all involved! Read more at doi.org/10.1083/jcb.... @mathildemathieu.bsky.social @martina-lerche.bsky.social

De nombreuses personnalités du monde culturel, académique, scientifique, dont El Mouhoub Mouhoud, président de l'Université PSL, et plusieurs membres de la communauté PSL ont signé l’appel lancé par @radiofrance.fr en faveur de la liberté de savoir. Lire l’appel 👉 www.radiofrance.com/actualite/ra...

Radio France lance un appel pour la liberté de savoir | Radio France

Appel pour la liberté de savoir

radiofrance.com

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…

sciencedirect.com

Are you looking for a postdoc? I will be looking for 2-4 people after the summer to join the lab !! Do not hesitate to reach out and disseminate !!

1/ Beyond thrilled to see my #PhD work now published in @jcb.org A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados

Journal of Cell Biology@jcb.org · last yr.

@gounismichalis.bsky.social‬ et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...

Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

Happy to share our Tensin 1 phase separation project is now on bioRxiv. www.biorxiv.org/content/10.1... This wouldn't be possible without @johannaivaska.bsky.social @ivaskalab.bsky.social #VattulainenLab #MSCA by @ec.europa.eu @turkubioscience.bsky.social @inflames-flagship.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics

Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

biorxiv.org

Haven't registered for "Advances in mechanobiology" yet? No problem!! We've got you covered!!! Just scan the QR code below or head over our website: themeshwork2020.wixsite.com/info/up-comi... @drsarahboyle.bsky.social @mathildemathieu.bsky.social @ivaskalab.bsky.social @carstenschulte4.bsky.social

‼️Typos happen to everyone. So small correction RE: "Advances on Mechanobiology" session. Thursday, Feb. 6 and not Tuesday. Still, plenty of time to register for this session. All things mechanobiology coming your way. Detailed program below! Join us: themeshwork2020.wixsite.com/info/up-comi...

🔔📢 Next event is fast approaching, so here is the complete program for next week's "Advances in Mechanobiology" session. @drsarahboyle.bsky.social @carstenschulte4.bsky.social @mathildemathieu.bsky.social Moderator: @ccstorytime.bsky.social Info: themeshwork2020.wixsite.com/info/up-comi...

I will be talking about my work on negative durotaxis of metastatic breast cancer cells. Thanks @themeshwork.bsky.social for the invitation!

The Meshwork@themeshwork.bsky.social · 2y ago

Our first event for 2025 is here 🥳Starting off strongly with a session dedicated to Mechanobiology 📅 Feb 6, 2025 | 🕒 12 PM CET. @drsarahboyle.bsky.social @carstenschulte4.bsky.social @mathildemathieu.bsky.social will share their innovative work with us. @ccstorytime.bsky.social will be chairing

Passing by Florence before heading to the directed cell migration Gordon Research Seminar and Conference in Lucca tomorrow!

Ivaska Lab at the Turku Bioscience Pikkujoulu party 🥳 Can you recognize our costumes? 😉 @omkarjoshi.bsky.social @mathildemathieu.bsky.social @mchastney.bsky.social @gounismichalis.bsky.social @sanshiya04.bsky.social

Here is the most recent preprint from our most recent PhD graduate, Dr Nicolas Pasquier. Orientation of mucinous CRC apicobasal polarity is regulated by tumor-stroma interactions. This work was a collaboration with the Jaulin lab at the Gustave Roussy Institute. www.biorxiv.org/content/10.1...

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity

Mucinous colorectal carcinoma (MUC CRC) dissemination into the tumor stroma and metastasis to multiple organs, including the peritoneum, is associated with poor prognosis. Disseminating MUC CRCs exhib...

biorxiv.org

After almost 4 years in Finland I am still excited about the first snow of the season 🌨️🤩

@ivaskalab.bsky.social is here now 🎉🦋

For my first post here, as an introduction of my background and what I used to work on, here is the publication from my PhD where I used the RUSH system to follow the trafficking of EV cargoes. Any #extracellularvesicles and #exosomes enthusiasts around here? www.nature.com/articles/s41...

Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 - Nature Communications

Extracellular vesicles (EVs) play a role in intercellular communication, however the precise biogenesis of different populations of EVs are not clear. Here, the authors follow the intracellular t...

nature.com