Data identify signal regulatory protein gamma (SIRPγ) as a negative regulator of CD8 T cell effector programming. Researchers suggest SIRPγ may be a therapeutic target in settings of dysregulated T cell responses. Learn more: https://ow.ly/o79B50ZvWAL.

Data demonstrate an IL-9–dependent suppressive circuit that is evident early in the development of systemic lupus erythematosus, which could be manipulated for therapeutic benefit. Learn more in ImmunoHorizons: https://ow.ly/8PIl50ZvWyS.

New mechanistic insights into the generation of sustained monocyte low-grade inflammatory memory help identify potential therapeutic strategies to erase low-grade inflammation associated with chronic diseases. 🔗 https://ow.ly/by8950YySp6

#CXCR4 blockade–mediated reprogramming of the perivascular tumor microenvironment promoted effective T-cell trafficking and function, providing a rationale for combining oncolytic virotherapy with adoptive cell transfer in #ovariancancer. 🔗 https://ow.ly/KHgi50YyShV

Data indicate that repeated SARS-CoV-2 vaccinations remodel the cellular and humoral immune landscapes in kidney transplant recipients, underscoring the importance of tailored vaccination strategies that optimize immune protection. 🔗 https://ow.ly/lFt150YySft

🚨 Paradigm Shift: New data in ImmunoHorizons suggests Hypermobile Ehlers–Danlos Syndrome (hEDS) includes innate immune dysfunction. This discovery may redefine how we diagnose and treat #hEDS moving forward. 🔗 https://ow.ly/nPMX50YWGFw.

#ICYMI New data show that the adapter functions of the inositol phosphatase SHIP-1, rather than the phosphatase activity, account for the inhibition of ERK by FCRL1 in addition to the recruitment of FCRL1 to the B cell receptor cap. Learn more: https://ow.ly/P4qg50Z4Gsw.

Researchers sought to determine the effect of natural microbial exposures on the immune composition of bone marrow and spleens of male and female mice from a single exposure to dirty bedding from pet store mice. 🔗 https://ow.ly/8b3Y50Z7fEY

#ICYMI Researchers sought to determine the effect of natural microbial exposures on the immune composition of bone marrow and spleens of male and female mice from a single exposure to dirty bedding from pet store mice. See more in ImmunoHorizons: https://ow.ly/8b3Y50Z7fEY.

New data show that the adapter functions of the inositol phosphatase SHIP-1, rather than the phosphatase activity, account for the inhibition of ERK by FCRL1 in addition to the recruitment of FCRL1 to the B cell receptor cap. Learn more: https://ow.ly/t0oz50Z7fO5.

Researchers sought to determine the effect of natural microbial exposures on the immune composition of bone marrow and spleens of male and female mice from a single exposure to dirty bedding from pet store mice. See what they found in ImmunoHorizons: ow.ly/8b3Y50Z7fEY.

IH is proud to support the 2026 AAI ASPIRE award recipients and introduce their contributions to immunology through a special collection. Read more from Anna Globig, Pamela Rosato, Jenna Guthmiller, Brandon Dekrosky, and @reinacampos.bsky.social: academic.oup.com/immunohorizo...

📢 Calling all AAI Members! The RESTORE Grants Program is officially accepting applications on a rolling basis. If your research has been impacted by federal funding disruptions unrelated to scientific merit, we want to hear from you. Learn more and apply now: https://ow.ly/ABtJ50YZxGC.

Review @immunohorizons.bsky.social Cellular and molecular interactions underlying the peripheral immune responses to blood-stage malaria infections academic.oup.com/immunohorizo...

🚨 Paradigm Shift: New data in ImmunoHorizons suggests Hypermobile Ehlers–Danlos Syndrome (hEDS) includes innate immune dysfunction. This discovery, currently trending on @Altmetric, may redefine how we diagnose and treat hEDS moving forward. 🔗 ow.ly/nPMX50YWGFw.

This special issue of ImmunoHorizons, guest-edited by Dr. Yiliang Chen, highlights macrophages in the heart and discusses the role and impact of these cells in cardiovascular disease: ow.ly/vn2H50YyScp.

Volume 10 Issue SI | ImmunoHorizons | Oxford Academic

ImmunoHorizons is a fully open-access peer-reviewed journal committed to advancing the knowledge of immunology and immunology education.

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#ICYMI ImmunoHorizons is excited to share a Special Collection focused on avian influenza, featuring 3 reviews on factors impacting emergence and spread #OneHealth, characteristics of current H5N1 strains, and a method for vaccine design. Read more: ow.ly/6HN550XSZop.

Volume 9 Issue SI | ImmunoHorizons | Oxford Academic

ImmunoHorizons is a fully open-access peer-reviewed journal committed to advancing the knowledge of immunology and immunology education.

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When comparing salivary IgA antibody levels in those with vaccine-only vs vaccine-and-infection immunity, researchers found that IgA levels to spike and RBD are high in those with hybrid immunity but low in those with vaccine-only immunity. Read more: ow.ly/Xg8W50XNcci.

Rapid decline of SARS-CoV-2–specific salivary IgA antibody levels in people with hybrid immunity—data from the STOPCoV study

Abstract. Hybrid immune individuals who experience an infection after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine series sh

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Are you passionate about immunology and ready to gain hands-on advocacy experience? The AAI PPFP 2026-27 is about more than understanding science policy—it's about making scientists heard. https://www.aai.org/Public-Affairs/PPFP?utm_source=bsky&utm_medium=social&utm_campaign=PPFP_2026#gsc.tab=0.

AAI Member Dr. Elizabeth Jaffee from Johns Hopkins Medicine shared with #ImmunologyExplained the powerful story of how her research is changing outcomes for patients with pancreatic cancer. Learn more and watch the video: ow.ly/mKx550XyhEC.

Exciting Breakthroughs in Pancreatic Cancer Research - Immunology Explained

From vaccines that prevent pancreatic cancer entirely to treatments that shrink tumors and make surgery more successful, major breakthroughs are happening in pancreatic cancer research.

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Researchers sought to determine if pre-existing immunity to Cas9 from S. aureus or S. pyogenes was present or augmented in people with cystic fibrosis (CF), as a cure for #CF will likely require a gene therapy approach. Learn more in ImmunoHorizons: ow.ly/9MUj50XsYlK.

Detection of pre-existing immunity to bacterial Cas9 proteins in people with cystic fibrosis

Abstract. Cystic fibrosis (CF) is caused by homozygous mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in multi

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Researchers found that exogenous type I interferons, a major downstream product of STING activation, also upregulate CCL22 in cancer cells via a STING-dependent mechanism and that exogenous IFN-β can directly activate STING. Learn more in ImmunoHorizons: ow.ly/C11i50Xmw7h

Tumor cells upregulate CCL22 in a STING-dependent manner in response to paracrine factors released by STING-activated myeloid cells and type I interferons

Abstract. Immunosuppressive elements within the tumor microenvironment include both regulatory T cells (Tregs) and M2 macrophages. A well-described mechani

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The synergistic activity of LIGHT with other classical cytokines was observed to regulate transcription in pulmonary fibroblasts and suggests the involvement of LIGHT in shaping fibroblast phenotypes observed in chronic lung disease. 🔗 ow.ly/pGOn50Xmwlq. #OpenAccess

LIGHT in combination with IL-13 or IL-17 drives inflammatory transcriptional signatures in human pulmonary fibroblasts relevant for human lung disease

Abstract. Fibroblasts are structural cells primarily involved in tissue remodeling, but recent single-cell RNA sequencing (RNA-seq) transcriptomic data hav

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Researchers found that exogenous type I interferons, a major downstream product of STING activation, also upregulate CCL22 in cancer cells via a STING-dependent mechanism and that exogenous IFN-β can directly activate STING. Learn more in ImmunoHorizons: ow.ly/C11i50Xmw7h

🎃 Happy Halloween! Ever wondered what your immune cells would wear to a costume party? 🚑 Neutrophil as an EMT: First responder on duty! 🥷 Killer T-Cell as a K-Pop Demon Hunter: Eliminating threats with precision! What do you think each immune cell would wear for Halloween?

#DYK We published one of the 6 spookiest discoveries of the year according to @zmescience.bsky.social? As a ghost passes through a wall, the parasitic work Schistosoma mansoni can pass through your skin without being detected. Read more: ow.ly/yIUS50Xl7h3. 📘 ow.ly/189i50Xl7h4

Zombie Ants, Spider Bait, and a Sneaky Burrowing Worm: The 6 Spookiest Science Discoveries of the Past Year

The natural world is full of discoveries that feel straight out of a Tim Burton fever dream.

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CHPE and metformin can modulate immune responses and improve gland function in mouse model of Sjögren’s disease via interaction with antigen-binding grooves of MHC Class II, with effectiveness varying by sex and age academic.oup.com/immunohorizo... @immunohorizons.bsky.social

Get ready for #IMMUNOLOGY2026™! We're heading to the vibrant city of Boston, MA. Prepare for groundbreaking science, incredible networking, and an unforgettable experience. Don't miss your chance to be part of the #immunology community! Learn more: immunology2026.aai.org/abstracts.

Join us for IMMUNOLOGY2026™

YouTube video by The American Association of Immunologists (AAI)

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🚀 New from AAI: Immunology Explained — a hub for clear, evidence-based insights into how the immune system protects health. Check it out: immunologyexplained.aai.org Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube #ImmunologyExplained

An essential conversation during #PeerReviewWeek! We hosted the webinar "How to Be the Reviewer You Want to Have," presented by Dr. Gail A. Bishop, EIC of @jimmunol.bsky.social. It's a key topic for graduate students and post-docs. Watch now: ow.ly/mAXQ50WZ1kH #TBT #PeerReviewWeek