Happy to share the lab's latest work characterizing the impact of a youth-associated protein on microglial function. Congrats to 1st author Brittany Hemmer, w/ excellent contributions f/ Sarah Philippi and all co-authors! @sinaibrain.bsky.social Paper: www.nature.com/articles/s41...

Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice - Nature Communications

Aging disrupts microglial function, but factors that rejuvenate these cells are poorly characterized. Here, the authors show the youth-associated protein TIMP2 revitalizes microglia by altering inflam...

nature.com

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀 Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities. Sign up. Stay informed. Join the movement: www.nycures.org/

Excited to share a new preprint out from the lab (www.biorxiv.org/content/10.1...) by 1st-author Brittany Hemmer, a newly minted PhD from the lab! A brief thread on what we found (1/n):

Youth-associated protein TIMP2 alters microglial state and function in the context of aging

There is little understanding of how aging serves as the strongest risk factor for several neurogenerative diseases. Specific neural cell types, such as microglia, undergo age-related maladaptive chan...

biorxiv.org

🎉Thrilled to announce that my awesome PhD student, @brittany_hemmer , successfully defended her thesis! Her thesis work is now preprinted (brief summary to follow)—proud of her hard work and perseverance!

Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social! Registration 🔗 us02web.zoom.us/meeting/regi... #NewVisionResearch #ProfessionalDevelopment

Zoom your career 🤓🧠🧬https://us02web.zoom.us/meeting/register/tIp9vIuwSF2LJydcdpDIxQ#/registration

Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.

Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.

us02web.zoom.us

Fantastic talks at #CCAD2025 Reunion Conference! @sinaibrain.bsky.social @jmcastell.bsky.social, Panos Roussos and Kuan-Lin Huang

Charleston Conference on Alzheimer's Disease (CCAD)@the-ccad.bsky.social · 2y ago

Day 2 of the CCAD Reunion Conference did not disappoint! Great conversations, poster sessions, and a fantastic group of scientists. #CCAD2025 #AlzheimersResearch #NewVisionResearch @malutansey.bsky.social @panosroussos.bsky.social @bobalhill.bsky.social @hoppzor.bsky.social @bucklr01.bsky.social

Our latest in PNAS! 🎉 ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep Take home message? KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions. www.pnas.org/doi/10.1073/...

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS

Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...

pnas.org

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

rdcu.be

Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube! Please like and repost to help us get the word out! www.youtube.com/playlist?lis... Lecture 1: Signals and data acquisition Focusing on hardware, digital/analog I/O, synchronization 🧵

Neuroscience methods - YouTube

Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...

youtube.com

Atlas of the plasma proteome in health and disease in 53,026 adults. #Cell #medBsky #SciBsky #scisky #proteome These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com). Open Access www.cell.com/cell/fulltex...

Updated Aging Starter Pack!! People and labs interested in aging 😀 Let me know if you'd like to be added! go.bsky.app/5UXXaDA

Hello Bluesky! 🦋 I’m an Associate Professor of #Neuroscience at the Icahn School of Medicine at Mount Sinai. I study how memories are stably stored and flexibly updated across time and experience 🧠 I also develop open-source tech! Looking forward to connecting here! #Neuroskyence #WomenInSTEM

go.bsky.app/Lyzro3M !WELCOME! thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list. apologies for missing many of you - please do reply to get added and remember to repost so the newbies can find us!

Our study is out! TIMP2, prev tied to blood-borne revitalization of aged brain, regulates hippocampal plasticity via the extracellular matrix. Great teamwork f/ 1st-author Catarina Ferreira + the whole lab, +collaborators Tim Ahfeldt, Merina Varghese, and Patrick Hof! www.nature.com/articles/s41...

Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity - Mole...

Molecular Psychiatry - Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

nature.com