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Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 2mo ago

MedPage Today @medpagetoday.com quotes @brianrifkin.bsky.social et al on CKM guidelines/staging www.medscape.com/s/viewarticl... I do think CKM is a fake made up condition & the staging is a terrible idea Flozinate, glipinate - but shoving another disease and staging and guideline? Count me out!

Happy #ClinicalTrials Day Trial design and conduct is no place for novices with best intentions. Patient participants make sacrifices. Medical progress holds its breath. Large sums of public and private money is invested. So get it right, from the start. statsepi.substack.com/p/dealing-wi...

Dealing with

There are no negative trials - just ones we learn from and ones we don't

statsepi.substack.com

Really cool paper

@jamesyoungevans.bsky.social · 5mo ago

Out today in @science.org: with the amazing Haochuan Cui, Yiling Lin, & @lingfeiwu.bsky.social, we analyzed 3.6 million scientists publishing 1960–2020. The findings reshape a century-old debate about age and scientific creativity.

Find out if standard ECG features or heart rate variability (HRV) parameters effectively predict the risk of heart failure hospitalization in patients with CKD in this #ASNKidney360 study. kidney.pub/KID1175 Qandeel Soomro

Here is today’s #eyeSCANdy! Scanning EM of a normal glomerulus showing a glomerular capillary loop with interdigitating podocyte foot processes. Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath

Issue 35 of #rdmweekly is out! Including: ➡️ Building Realistic Fake Datasets with Pointblank @richmeister.bsky.social ➡️ Rethinking TXT Files @kbriney.bsky.social ➡️ Economic Benefits of OS @plos.org ➡️ What Is Data Governance? @thegovlab.org and more! Link: rdmweekly.substack.com/p/rdm-weekly...

Not every biological phenomenon we can’t explain entirely at the moment is a syndrome. Not everything is a “vicious cycle” or “bidirectional”. Poorly thought out terminology-> intellectually lazy hypotheses and questions

ASN Publications@asnpublications.bsky.social · 7mo ago

How clinically relevant is a cardiovascular-kidney-metabolic syndrome (CKM) diagnosis? This perspective in #ASNKidney360 explores similarities, differences, and future directions for Metabolic syndrome (MetS) and CKM. Read the perspective here: kidney.pub/KID1140

well said - indeed a peer review system in crisis hard to find someone to review burden of review duplication and waste misuse/corruption of peer review www.kidneynews.org/view/journal... in @asnpublications.bsky.social Kidney News #NephSky

PSA: From a causal inference perspective, if there are multiple confounders, you should *very much* include them simultaneously. That is the one way to rule out that their joint contributions don't fully explain away what you are interested in. journals.sagepub.com/doi/full/10....

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journals.sagepub.com

Yeah, people mean that there is a feedback loop between the values of each variable over time. Which is not bidirectional. And not a loop. Zach Kunicki & I wrote an explainer on this but it never made it out of pre-print. osf.io/preprints/os...

The JASN editorial team has selected the following articles to highlight as 2025 Editors’ Choice Articles. They exemplify the highest potential to inform future research, change clinical practice, and/or guide public policy. They will be freely available until February 23: kidney.pub/JASNRecog...

Neat review on supine hypertension...the next coolest thing in hypertension research (in my humble opinion)! www.nature.com/articles/s41... Love this figure! @rueyhu.bsky.social

2025 James S. Kaufman Early Career Award winning article: Extreme Humid-Heat Exposure and Mortality Among Patients Receiving Dialysis bit.ly/4rTeNh2 (FREE temporarily) #VisualAbstract

Coronary artery disease is a barrier to kidney transplantation. This new meta-analysis in #ASNJASN investigates how many patients meet class 1 indication for revascularization. Read more: kidney.pub/JASN0890 @qandeelsoomro.bsky.social

We are live The @theisn.org launches a new journal www.sciencedirect.com/journal/kidn...

A lot of funny opinions about the fish oil RCT. People have spent their entire careers trying to understand the complex pathophysiology of high cardiovascular mortality in those with CKD. Here all we were waiting for is fish oil!

Mike Johansen@mikejohansenmd.medsky.social · 11mo ago

The editorial of this paper is kind of funny. They don't recommend use given "outsized results of early trials have failed to be replicated". Given the effect size is ginormous, the likelihood that any meta-analysis would not show that this is beneficial is very small. www.nejm.org/doi/full/10....

No no no begs every archivist. You are never going to be able to find anything. Please don’t start using emojis in file names. Who asked for this? What fresh hell is next?

“Pause before accepting such remarkable results as gospel” hmm probably good advice from my mentor

NEJM.org@nejm.org · 11mo ago

Editorial: Fish Oil for Patients Receiving Hemodialysis — Red Herring or Great Catch? nej.md/49zWAOM

(1/3) Paying close attention to morphologic detail can sometimes suggest etiologic clues in cases of severe chronic renal injury. The glomerulus in this image, for example, shows near complete global glomerulosclerosis. #TeachingPoints #kidneypath #nephsky #pathsky #renal

It has been 2 years since Rajnish Mehrotra stepped up to become the inaugural senior editor-in-chief of the ASN Publications portfolio. Read the interview with #ASNKidneyNews here to learn more about the portfolio structure and what's next here: kidney.pub/KN1710-17 @rajmehrotra.bsky.social

Pfft so patronizing #LLMfail

How about instead:

If people knew how many medical guidelines are based on change scores getting predicted from baseline severity, everyone would be really scared

This paper’s been popping as “evidence” that you can’t do real #causalinference w/ obs data. To me it shows you need rigorous pre-specified design (in addition to the willingness to fold when your hypothesis is not possible to answer with the data at hand). #EpiSky, #CausalSky, #AcademicSky

One of the adaptive designs we are seeing more frequently is the Sequential Multiple Assignment Randomised Trial (or SMART trial) 1/7 #MethodologyMonday #126

The opening plenary at #KidneyWk looks phenomenal Renal RCT Renaissance is upon us (LBCT list drops tomorrow) www.asn-online.org/education/ki...

I read and write, I explore and I question, I design and script and analyse, I interpret and communicate. I do this to train my mind in the hopes of one day generating new knowledge. New knowledge that might even be useful, and that no algorithm can yet be trained on.

Terry McGlynn@hormiga.bsky.social · 12mo ago

Y'all. I just got ChatGPT to do everything in R for this manuscript. I mean EVERYTHING. And it's all legit and reproducible. I'm shook. How are we mentoring our trainees in statistics now? Who needs to learn coding in R line by line, and who doesn't? scienceforeveryone.science/statistics-i...

This is a nice paper. It faces down a common problem: in order to explain to why a common approach cannot work even in theory, we first need to teach a framework in which regression is not magic that tells us which variables on right cause the variable on left. It's exhausting. Anyway great paper!

Peter Tennant@pwgtennant.bsky.social · 12mo ago

academic.oup.com/ije/article/...

"Uncooperative statistician": the term used (typically by a senior clinician) to describe a well-trained and knowledgeable statistician who refuses to conduct flawed or fraudulent research.