How do cells sense tissue damage - and help their neighbors withstand it? Our new paper on the redox-sensitive 5-oxoETE lipid pathway shines light on this question. A huge THANK-YOU to all the colleagues and funding bodies that made this work possible! www.nature.com/articles/s41...

5-oxoETE links redox control of epithelial damage detection and resilience - Nature

The DHRS7–OXER1 pathway links oxidative stress to immunity and tissue resilience by modulating 5-oxoETE via NADP+–NADPH, activating OXER1 to recruit antimicrobial cells and induce NUDIX enzymes t...

nature.com

👉Two fascinating, conceptually intertwined stories from my lab will finally be published this Wednesday. MASSIVE KUDOS to the two fearless postdoctoral scholars, Yanan Ma and Miklos Lengyel, whose ingenuity, resilience, and team spirit made all of this possible! A little reminder:👇🧵

Philipp Niethammer@niethammerlab.bsky.social · 2y ago

While the US science ship is shaking, on a brighter note: two new preprints from the lab. In the first, we identify a long sought, enzyme of eicosanoid metabolism, 5-HEDH, which regulates inflammatory lipid synthesis and breakdown as a function of tissue redox state. www.biorxiv.org/content/10.1...

👉 The Niethammer lab has two postdoctoral openings. We’re looking for researchers interested in how organelle mechanotransduction and redox signaling shape early responses to tissue injury. If interested, please reach out to me with a CV and letter of intent written in your own words (🚫 AI).

Electrochemical response triggers organ growth, following tail injury in a #zebrafish embryo. Credit to @ritamateus.bsky.social, @nerlielisa.bsky.social, & @liujinghui.bsky.social. #ZebrafishZunday

Don´t know yet what you´ll be doing next April? Why not join us for a great meeting in Porto? Registration for Forces across scales is now open! meetings.embo.org/event/27-for...

Forces across scales

This EMBO Workshop on Forces Across Scales will provide an integrative perspective on mechanobiology, a rapidly advancing field that examines how mechanical forces shape biological systems across mol…

meetings.embo.org

Drawing by hand is not just a nostalgic/cute way to generate visuals. A good scientific drawing generates a faithful model of reality through careful observation and humble craftsmanship - it epitomizes good science.

Royal Society Publishing@royalsocietypublishing.org · 3w ago

In order to understand early modern science, images are no less significant than words. A new #NotesandRecords special issue examines a wide range of images, from true-to-life drawings to carefully conceived schematics: royalsocietypublishing.org/rsnr/issue/8... #HistSci #HistSTM

sOrganellomics

Stella Hurtley@smhsci.bsky.social · 3w ago

Out now in @science.org Multi-organelle signatures map cell-state diversity and metabolic adaptation in tissues | Science www.science.org/doi/10.1126/...

Once in a while a student like Zaza comes along - so unafraid, and with so much skill, determination and pure, contagious joy for science and discovery, you remember that you also picked the job for meeting just such people. www.mskcc.org/news/2026-gs...

👉1/3 We are looking for a research technician to join our lab at Sloan Kettering Institute in New York City. This is an ideal position for a recent college graduate (e.g., from the NYC area) interested in basic biology and gaining hands-on research experience before graduate or medical school.

Join us at the Gerstner Sloan Kettering Graduate School in one of the great cities of the world! www.sloankettering.edu/gerstner/wel...

When threatened, a pufferfish fills its stomach with water (or air), reaching 3-4X their original size. That requires specialized adaptations. What you see below are the caltrop-shaped spines that change configuration with expanding skin. But these aren't the /bones/ of the fish. They're scales.

Adaptive motility enables neutrophils to rapidly navigate confined capillaries | Science Immunology www.science.org/doi/10.1126/...

Adaptive motility enables neutrophils to rapidly navigate confined capillaries

Neutrophils maintain migration speed in confined capillaries through adaptive actomyosin remodeling.

science.org

The strongest "methods" of philosophy are those that throw you out of cozy "sureness" and the "well established". If you let this happen, you start philosophizing. No academic titles needed.

New facets of eicosanoid signaling in TB: crosstalk with a specialized population of granuloma-associated fibroblasts. Happy to share new work led by Erika Hughes, with @charliejpyle.bsky.social and many other wonderful collaborators not on BlueSky.

Host eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial containment

Hughes et al. find that the TB susceptibility gene lta4h contributes to the recruitment and differentiation of a discrete set of fibroblasts that populate the periphery of mycobacterial granulomas in ...

cell.com

Philosophy is not about being "sure", it is exactly about the opposite 😜.

Susana Monsó@susanamonso.com · 2mo ago

I wrote a little something on the value of philosophy for animal cognition. Out now in Science’s Expert Voices column.

Ever wondered how epithelial cells clear apoptotic cells while maintaining tissue cohesion?🍝🔗 Check our new paper in which we show that E-cadherin plays a dual role in regulating basal cortex dynamics upon phagocytosis while maintaining connected tissue organization www.nature.com/articles/s41...

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance - Nature Communications

Epithelial cells remodel their shape during phagocytosis while preserving tissue cohesion. Here, authors show that the E-cadherin/catenin adhesion complex is repurposed at phagocytic contacts, where i...

nature.com

Interested in nuclear mechanobiology and want to know what some of the big open questions are in the field? Read our recent editorial with input from >15 leading experts in the field, along with a list of review articles on nuclear mechanobiology: www.tandfonline.com/doi/full/10....

Nuclear mechanobiology: a brief history and five unresolved questions

Published in Nucleus (Vol. 17, No. 1, 2026)

tandfonline.com

👉1/3 We are looking for a research technician to join our lab at Sloan Kettering Institute in New York City. This is an ideal position for a recent college graduate (e.g., from the NYC area) interested in basic biology and gaining hands-on research experience before graduate or medical school.

Last week in @science.org A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo | Science www.science.org/doi/10.1126/...

A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo

The cellular distribution of mitochondria in response to stress and local energy needs is governed by the relative activities of the microtubule-based molecular motors kinesin and dynein. The mechanis...

science.org

A 15-year history of my lab in signed champagne bottles. We always find some reason to celebrate: papers, fellowships, prizes - 🙏 to all the good people in the lab. Yet we have never opened the BIG bottle - now it's time 😅. Hope it fits on the shelf.

Very interesting work! www.nature.com/articles/s41...

I just updated LCS turbo adding a compatible Connector app at Zenodo. The Connector connects logical or marker/scRNAseq clusters across different experiments/data sources into Cytoscape compatible enrichment networks. Hope it is useful - I count downloads as ❤️. zenodo.org/records/2064...

Philipp Niethammer@niethammerlab.bsky.social · 4mo ago

Now live: LCS 3.0 engine rebuild with C++ with command line our GUI interface. Optional bioconductor edgeR filters and stats (slow), and fast internal stats (correlationdistance & welch test). Can be integrated into any bioinformatics pipline as executable. (1/5)🧵 zenodo.org/records/2063...

Independent thinkers are rare, technically adept followers are plenty. Understanding/questioning what is closest to us -current concepts, life, reality, ourselves, etc- is the most difficult thing. It has never been different. No wonder that many people prefer to 👉 „shut up and calculate“ 😉

Thiago Carvalho@cyrilpedia.bsky.social · 3mo ago

"For me, the ending of the talk was the most relevant part. Chalfie asked how we can become better at making new discoveries. His answer was surprisingly simple: we need to 'question what is right in front of us' and 'question our assumptions'." network.febs.org/posts/thinki...

EZM2026 setting a very high bar for future social events 🍾🥂

European Zebrafish Society (EZS)@ezsociety.bsky.social · 3mo ago

What a night! Thank you @wien.gv.at for hosting us, the organizers to make this happen and the amazing quartet for the music. #EZM2026

My favorite summer tune!

Phil Abitua@ohnolog.bsky.social · 3mo ago

When your favorite artist comes out of nowhere with a track about chick development, it really feels like you’re living in a simulation. www.youtube.com/watch?v=cDCI...

www.nature.com/articles/s41...

CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

nature.com

gut.bmj.com/content/earl...

Pancreatic cancer fibrosis activates protumorigenic Schwann cells through a nuclear mechanosensing mechanism

Background Fibrosis and tumour innervation are two features of the tumour microenvironment (TME) that contribute directly to the lethality of pancreatic ductal adenocarcinoma (PDAC), but their potenti...

gut.bmj.com

Next week - looking forward to see you there! www.ezm2026.org

European Zebrafish Meeting 2026 - July 7-11, 2026 - Vienna

Create a professional science website with Avada. Showcase research, highlight discoveries, and engage your audience with custom, informative designs.

ezm2026.org

So proud of @sydsat.bsky.social, the lab’s first graduate student, for leading this work! Special thanks to the Searle Scholars Program and the Royalty Research Fund for making it possible. Check out the preprint here: www.biorxiv.org/content/10.6...

Early immune cell development precedes gastrulation in annual killifish

During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

biorxiv.org