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Surfin' NuRD

@surfinnurd.bsky.social

Ahh well-a everybody's heard about the NuRD. #NuRDistheWord Cycling/Chromatin Remodelling/Transcription/Enhancers/StemCells We've got it all. Living Systems Institute, University of Exeter https://lsi.exeter.ac.uk/groups/hendrich-group/

538 Posts2708 Follower826 Folgt
Raphaël Pantier@r-pantier.bsky.social · 2w ago

Our laboratory is looking for a PhD student in Functional Genomics (fully funded position). Expected starting date: Oct 2026 More info here: www.igbmc.fr/en/igbmc/lif... Please share 📨

IGBMC: PhD position available in Raphaël Pantier's lab

igbmc.fr

IGBMC@igbmc.bsky.social · 2w ago

PhD position in Functional Genomics, in Raphaël Pantier's lab: Interplay between transcription factors and genome architecture in embryonic stem cells more info : amethis3.unistra.fr/amethis-clie...

Count Binface@countbinface.bsky.social · 3y ago

Under a Binface government, anyone who doesn’t accept human-made climate change as fact will be sent back to school, from Year 1 right the way to A Levels, to see if anything goes in the second time round. #VoteBinface

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Ben Goldacre@bengoldacre.bsky.social · 3w ago

SUVs are higher at the front and three times more likely to kill a child when they hit them. SUV drivers drag the child under their vehicle, and then they crush the child to death. It's incredible that SUVs don't have higher tax, and why not lower speed limits. www.theguardian.com/commentisfre...

Britain’s cars and SUVs are growing bigger – but there is a way to stop this deadly ‘carspreading’ | Christian Wolmar

Larger vehicles crowd our roads and are far more dangerous to pedestrians. Let’s curb them before they do even more damage, says says transport commentator Christian Wolmar

theguardian.com

Courtney Hanna@cwhanna.bsky.social · 4w ago

Is the unusual DNA methylation landscape in extra-embryonic tissues a mammalian trait? I'm excited to share our latest work led by @georgiaplea.bsky.social, comparing the molecular signatures of trophoblast/extra-embryonic ectoderm between human, mouse and chicken. tinyurl.com/bdzesv2n

Conserved and divergent DNA methylation features of extraembryonic tissues between human, mouse and chicken - BMC Genomics

Background The first cell fate decisions in embryogenesis give rise to extraembryonic tissues, such as the yolk sac and placenta, which are essential for embryo survival. In mammals, extraembryonic cell types arising from these first lineage decisions show distinct DNA methylation patterning, including large partially methylated domains, gene body methylation and accumulation across developmental CpG island (CGI) promoters. Analysis of extraembryonic membranes beyond mammalian species has been limited. Using bisulphite-seq and RNA-seq, we comparatively define these epigenetic characteristics of extraembryonic tissues in both mouse and human. We then tested whether these features are conserved in the chicken extraembryonic membranes (EEMs) including the yolk sac, chorion and chorioallantoic membrane (CAM). Results Transcriptomic analysis revealed that embryonic day (E)4 yolk sac/chorion and E14 CAM express similar marker genes to the mouse chorionic trophoblast, supporting that the chicken chorionic ectoderm shares a ‘trophoblast-like’ cell identity. We find that partially methylated domains and transcription-linked gene body methylation patterning are highly conserved between mouse and human proliferative multipotent trophoblast cells but were not evident in the chicken EEMs. However, we find that methylation of CGIs associated with developmental genes was a conserved feature of mouse, human and chicken EEMs. Conclusions These findings support that features of the extraembryonic DNA methylation landscape have distinct underlying mechanisms. We find that only one feature is conserved across extant amniotes, suggesting distinct evolutionary pressures are associated with different features of EEM epigenetic landscape.

tinyurl.com

Alex Radzisheuskaya@a-radzisheuskaya.bsky.social · 4w ago

1/ Very excited to share the first publication from my lab! In this work, we developed an efficient strategy to precisely mutate mammalian histone genes in their native genomic context using CRISPR prime editing: www.nature.com/articles/s41...

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature Genetics

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...

nature.com

Luís M. Silva@luismsilva.bsky.social · last mo.

1/🧵 With this paper finally published, I want to talk about the worst peer review experience of my career as a non-native English speaker, early-career researcher, and solo author, and why I think it matters. #AcademicSky #AcademicPublishing #EvoSky

Luís M. Silva@luismsilva.bsky.social · last mo.

1/🧵 Excited to finally share my latest paper (and my first solo paper)! 🎉 Pathogens evolve. Hosts respond. But does pathogen evolution simply change the magnitude of the host response, or does it reshape which host programmes are activated? 🤔 👇 doi.org/10.1038/s420... #Anopheles #EvoSky

Lluis Montoliu@lluismontoliu.bsky.social · last mo.

Frank Grosveld, born in 1948, passed away last Friday. He was a colossal scientist in the transcriptional control of gene expression during development and helped us understand the complex regulation of beta-globin genes. His work will remain as a reference. May he rest in peace.

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Teif lab@teiflab.bsky.social · last mo.

1/9 A few thoughts and personal opinions on the use of AI in research evaluation. I suspect many of these changes may be inevitable, so the real question may not be whether this will happen, but how we shape it responsibly 🧵

Surfin' NuRD@surfinnurd.bsky.social · last mo.

Finally, more people have watched the new video than the old one (since re-posting). But Youtube says only 40% of you watch to the end! The "BDHLab in Action" shots at the end are my favourite bits. #Transcription #Chromatin #Enhancer #Signalling

Surfin' NuRD@surfinnurd.bsky.social · last mo.

NEW VIDEO KLAXON!! With sound! Extracellular signals cause a commotion at enhancers. Thank goodness NuRD is there to re-establish order! youtu.be/FangQlItLv0 Read all about it: www.biorxiv.org/content/10.6... Please spread the Word of the NuRD! #NuRDistheWORD

Anzy Miller@anzymiller.bsky.social · last mo.

Really interesting preprint, check it out - interesting to see how a rapid chromatin state change allows cells to be responsive to new signalling. Also - amazing video!!! My favourite are the cheeky transcription factors 🤩

Surfin' NuRD@surfinnurd.bsky.social · last mo.

NEW VIDEO KLAXON!! With sound! Extracellular signals cause a commotion at enhancers. Thank goodness NuRD is there to re-establish order! youtu.be/FangQlItLv0 Read all about it: www.biorxiv.org/content/10.6... Please spread the Word of the NuRD! #NuRDistheWORD

Dr Charlie Gardner@charliejgardner.bsky.social · last mo.

Reform UK councillors have introduced a motion to rescind King's Lynn and West Norfolk's climate emergency declaration and deprioritise decarbonisation efforts The council were going to vote on it on Thursday But the meeting has been postponed due to extreme heat

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