Join us! Research Fellow role at UCL @ukdri.ac.uk @uclqsion.bsky.social with me & @sj-marzi.bsky.social studying oligodendrocytes, genetics & epigenetics in ageing & neurodegeneration using multiomics/bioinformatics. Collaboration with Alexi Nott & @rikeshrajani.bsky.social Closing date: 2nd June

Dementia Researcher@dementiaresearcher.bsky.social · 3mo ago

Research Fellow role at UCL @ukdri.ac.uk with @dervissalih1.bsky.social studying oligodendrocytes, genetics and epigenetics in ageing and neurodegeneration using multiomics and bioinformatics. Closing date: 2nd June www.dementiaresearcher.nihr.ac.uk/job/research...

The @ukdri.ac.uk at University of Edinburgh is recruiting a Research Fellow to study oligodendrocytes in vascular and Alzheimer’s dementia using iPSC models and epigenetics. Closing date: 19th May www.dementiaresearcher.nihr.ac.uk/job/research...

Research Fellow: Oligodendrocyte changes in Vascular & Alzheimer’s dementias

University of Edinburgh seeks a Research Fellow to study oligodendrocytes in vascular and Alzheimer’s dementia using iPSC models and epigenetic insights.

dementiaresearcher.nihr.ac.uk

The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to grow human iPSC-derived oligodendrocytes in vitro and investigate how gene regulatory changes affect oligodendrocyte function in Alzheimer’s disease. Apply here 👇 bit.ly/4tVip2k

New research sheds light on why Alzheimer's treatments targeting amyloid alone may not be enough 🧠 Prof @marcaurelbusche.bsky.social & Dr Robert Ellingford suggest the hallmark proteins amyloid beta and tau may work together to disrupt memory circuits 👉 ukdri.ac.uk/news-and-eve...

QR Special: The cruelty of Long Covid 👩‍⚕️ The brutal physical, mental, emotional, social & professional impact 😳 HOW many affected? 🚑 The battle to be taken seriously With @mrkennycampbell.bsky.social & Claire Higham 🎧 open.spotify.com/episode/1YGg... 🍎 podcasts.apple.com/us/podcast/t...

QR Special: The cruelty of Long Covid

open.spotify.com

We're excited to launch a new 4-year PhD studentship programme funded by @thebhf.bsky.social! 🙌 The programme will support up to 10 students across 2 intakes, investigating vascular mechanisms underlying dementia and neurodegeneration. ukdri.ac.uk/news-and-eve...

🚨 PhD Programme – Vascular Dementia Research New 4-year PhD funded by BHF & UK DRI on vascular mechanisms in dementia. Training across UCL, Oxford, Leicester & Edinburgh with lab rotations. 📅 Deadline: 14 April 🎓 Start: Sept 2026 Apply: CV + statement + 2 refs → neurophd@ucl.ac.uk Please share!

What role do oligodendrocytes play in Alzheimer's? 🔬 We're pleased to support a major new project led by @sj-marzi.bsky.social, @dervissalih1.bsky.social, @nottalexi.bsky.social & @rikeshrajani.bsky.social, to investigate how these cells influence neurodegeneration👉 www.ukdri.ac.uk/news-and-eve...

💫 A top highlight from last year was the official launch of our new Centre dedicated to revolutionising understanding and treatment of vascular dementia, in partnership with the British Heart Foundation ♥️ Find out more 👉 youtu.be/g8KLVN1ODfs?...

BHF - UK DRI Centre for Vascular Dementia Research

YouTube video by UK Dementia Research Institute - UK DRI

youtu.be

VIDA PhD studentship at The University of Edinburgh with Rikesh Rajani using iPSC-derived models to investigate vascular-oligodendrocyte interactions in vascular dementia. Closing date: 6th January www.dementiaresearcher.nihr.ac.uk/job/the-univ...

PhD: Vascular and oligodendrocyte work in inherited dementia

VIDA PhD studentship at University of Edinburgh with Rikesh Rajani using iPSC-derived models to investigate vascular-oligodendrocyte interactions in vascular dementia

dementiaresearcher.nihr.ac.uk

We have an exciting opportunity for a PhD student to join our lab and use iPSC-derived models to investigate vascular-oligodendrocyte interactions in vascular dementia. Details here: www.findaphd.com/phds/project...

VIDA DTC - Investigation of vascular-oligodendrocyte interactions using iPSC-derived models of inherited vascular dementia at University of Edinburgh on FindAPhD.com

PhD Project - VIDA DTC - Investigation of vascular-oligodendrocyte interactions using iPSC-derived models of inherited vascular dementia at University of Edinburgh, listed on FindAPhD.com

findaphd.com

Meet Dr @rikeshrajani.bsky.social , Group Leader at the BHF - UK DRI Centre for Vascular Dementia Research (CVDR)👋 Dr Rajani has dedicated his career to understanding white matter damage across multiple forms of dementia. Learn more about Dr Rajani's work 👉 tinyurl.com/3bwez8r6

🎉 This week, we’re proud to officially launch the BHF-UK DRI Centre for Vascular Dementia Research, in partnership with the British Heart Foundation. The centre will explore how changes in vascular health contribute to dementia - paving the way for new treatments👉 buff.ly/5ZEjQx8

📢 Job Alert 📢: Research Fellow in new national BHF-UK DRI Centre for Vascular Dementia Research. You will use in vitro and ex vivo techniques to investigate the relationship between endothelial cells, oligodendrocytes and neurons in the context of Alzheimer’s and vascular dementias. edin.ac/4nrMrIm

The Rajani Lab is hiring again! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate vascular-oligodendrocyte interactions in dementia. Apply here 👇 bit.ly/4nm8csZ

Just over a week left to apply for this position in our lab!

Rikesh Rajani@rikeshrajani.bsky.social · last yr.

The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia. Apply here 👇 bit.ly/44AFJHx

The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia. Apply here 👇 bit.ly/44AFJHx

📢JOB ALERT📢 @rikeshrajani.bsky.social is looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research. edin.ac/3GGUwZn

Amazing opportunity postdocs

Rikesh Rajani@rikeshrajani.bsky.social · last yr.

The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia. Apply here 👇 bit.ly/44AFJHx

The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia. Apply here 👇 bit.ly/44AFJHx

NEW FROM ME - Britain is abandoning international medical consensus on disability. Every other developed nation recognizes cumulative impairment as genuine severity. We're about to become an anomaly—and the logic of 4+ suggests it was deliberate. tinyurl.com/mwwb5xv4

Who Will Count as Disabled Tomorrow?

The dangerous redefinition of welfare disguised as Labour's compassionate reform.

tinyurl.com

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments. Apply here👇 shorturl.at/LpCAq

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

shorturl.at

More great work from the Busche Lab that I’m glad to have played a part in. Now out in @cp-neuron.bsky.social, we show that the earliest neuronal dysfunction in Alzheimer’s models is seen in parvalbumin interneurons in deep cortical layers.

Marc Aurel Busche@marcaurelbusche.bsky.social · last yr.

Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2. www.cell.com/neuron/fullt...

Delighted to have played a part in this work, now out in @cellpress.bsky.social, where we show how soluble high molecular weight tau from Alzheimer’s brain suppresses burst firing in hippocampal neurons.

Marc Aurel Busche@marcaurelbusche.bsky.social · last yr.

Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory. www.cell.com/cell/fulltex...

New research led by @marcaurelbusche.bsky.social has found that tau specifically disrupts a certain type of electrical activity in the hippocampus in Alzheimer's🧠 The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6

Excited to share that I'll soon be moving back to Edinburgh to start my own lab, as part of the BHF-UK DRI Centre for Vascular Dementia Research! The Rajani Lab will be recruiting soon, so keep your eyes peeled.

UK Dementia Research Institute@ukdri.ac.uk · last yr.

Delighted to announce @rikeshrajani.bsky.social as the first Group Leader to join our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏 The Rajani Lab will investigate how the protective myelin sheath around brain cells is damaged in small vessel disease👉 buff.ly/4hIGaVM

Delighted to announce @rikeshrajani.bsky.social as the first Group Leader to join our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏 The Rajani Lab will investigate how the protective myelin sheath around brain cells is damaged in small vessel disease👉 buff.ly/4hIGaVM

Link to British dementia work with @selinawray.bsky.social : link.springer.com/article/10.1... Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...

Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia - Acta Neuropathologica

Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-ter...

link.springer.com

My colleague @neuroschnell.bsky.social chose this study of the surprising role played by oligodendrocyte (rather than neuronal) amyloid in Alzheimer's: journals.plos.org/plosbiology/...

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease

Neurons are thought to be the primary source of pathogenic amyloid beta (Aβ) in Alzheimer’s disease. This study identifies oligodendrocytes as significant contributors to Aβ production and shows that ...

journals.plos.org