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Michele Frison

@frisophagy.bsky.social

Junior Group Leader at Goethe University Frankfurt. Lover of mitophagy and quality control. Fervid European. Obsessive environmentalist. Yoga enthusiast. Way too excited. Curator of mitophagy newsletter - https://biomed.news/bims-tofagi

81 Posts217 Follower 247 Folgt

Jelle van den Ameele @jellevda.bsky.social · 3mo ago

Visualising heteroplasmic mitochondrial DNA variants in situ? Now out as #mtDNA-smFISH in @cp-devcell.bsky.social! We find purifying selection against pathogenic mtDNA variants through genetic bottlenecks in the germline and the developing brain. www.cell.com/developmenta...

Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in vivo

Chandrasegaram et al. directly visualize mitochondrial DNA inside intact cells and tissues and reveal how genetic cell-to-cell variability arises during development. They show that somatic bottlenecks...

cell.com

Osman Lab @osman-lab.bsky.social · 6mo ago

🧬 Introducing the #mtDNA Lab Intel Pipeline! Our system daily scans PubMed and bioRxiv to bring you: 📄 #Gemini generated Daily Dossiers (PDF) and 🎙️ #NotebookLM generated Podcasts with a focus on #mtDNA-QC and #mtDNA-copy-number 📂 Full Archive: drive.google.com/drive/folder...

Square, neon-colored illustration announcing a “Daily Briefing” on mtDNA, showing mitochondria, DNA, AI icons, literature stacks, exercise symbols, and a bar graph, in a futuristic purple-pink style.

Michele Frison @frisophagy.bsky.social · 6mo ago

Good morning everyone, below is last issue of #mitophagy news 🪫 🔋 🗑️ biomed.news/bims-tofagi/... This week you'll find insights on the role of mitophagy in germline cells and in inheritance of mtDNA, in mice and in the male arabidopsis germline Thanks to @biomednews.bsky.social for pre-sorting

Michele Frison @frisophagy.bsky.social · 7mo ago

Welcome to another week of mitophagy papers! 🪫🗑️ biomed.news/bims-tofagi/... highlights: -A rab1 A Rab1 interactome illuminates a dual role in autophagy and membrane trafficking -a review on the role of superoxide in mitophagy -USP15 inhibition ameliorates PD phenotype in mouse models of disease

Figure 1. Rab1A and Rab1B MitoID ident ifies novel Rab1 effectors. (A) Schematic of the Rab1-MitoID approach in which Rab1 is fused to the promiscuous biotin ligase BirA* and a mitochondrial localization signal from monoamine oxidase (depicted in red), resulting in the relocalization of Rab1 to the mitochondrial membrane. Rab1 interactors will be efficiently biotinylated, while other Golgi proteins and Rab interactors are not. (B) Two-dimensional plot comparing the enrichment of proteins biotinylated by Rab1A-MitoID vs control (BirA alone), plotted against the enrichment of proteins biotinylated with GTP-locked Rab1A (QL) vs GDP-locked Rab1A (SN). For the x axis, the value plotted is that for the nucleotide form of Rab1 that gave the greatest fold change over background. For clarity, Rab1A itself is not shown, as it is part of the BirA* construct. Known effectors and regulators are indicated, with known effectors being enriched in the upper right quadrant. Zoomed regions to the right show a region demarcated by well-enriched known effectors with novel proteins of note identified. For all protein identities and enrichment values see Table S1. (C) as for (B) except with Rab1B rather than Rab1A. (D) Overrepresented GO terms for biological process of the proteins within the regions demarcated by known effectors shown in B and C with the known effectors removed. Ranking is by the summed FDR and enrichment rank. (E) Immunoblots of binding to GST-Rab1A–coated beads of the indicated proteins from HEK293A cell lysates. Rab1A was either Q70L (GTP) or S25N (GDP). The known Rab1 effector RABEP1 (rabaptin-5) is included as positive control (Valsdottir et al., 2001). Source data are available for this figure: SourceData F1.

Michele Frison @frisophagy.bsky.social · 8mo ago

MISO: An MTFP1 interactor that regulates inner mitochondrial membrane fusion and quality control MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains | Nature Cell Biology

MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains - Nature Cell Biology

Zhang et al. characterize the mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner mitochondrial membrane stress by inducing membrane subdomains promoting homeostat...

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Sam J Wilson @samjwilsonphd.bsky.social · 8mo ago

How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵 www.science.org/doi/10.1126/...

Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

science.org

RyanLab_TCD @ryanlab.bsky.social · 9mo ago

📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Exciting to have a paper in the collection! An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

Michele Frison @frisophagy.bsky.social · 9mo ago

In this week's mitophagy news: -a novel screen for endogenous modulators of PINK1-Parkin pathway uncovers unstudied dependencies -autophagy regulation by phase separation, avidity and wetting -a bacterial mitophagy receptor to evade inflammation biomed.news/bims-tofagi/...

Journal of Cell Biology @jcb.org · 9mo ago

Liu et al. discover that pathogenic bacteria use a shared strategy to exploit the host’s cellular recycling process, #mitophagy. Through an effector protein that acts as an external receptor, bacteria suppress inflammatory responses to promote #infection rupress.org/jcb/article/... #Autophagy

David Pla Martin @dplamartin.bsky.social · 9mo ago

link.springer.com/epdf/10.1007...

Mitochondria quality control: preserving the cells’ command center

link.springer.com

Eric Chevet @ericchevet.bsky.social · 9mo ago

Ultra-processed foods and human health: the main thesis and the evidence - The Lancet www.thelancet.com/journals/lan...

Ultra-processed foods and human health: the main thesis and the evidence

This first paper in a three-part Lancet Series combines narrative and systematic reviews with original analyses and meta-analyses to assess three hypotheses concerning a dietary pattern based on ultra...

thelancet.com

Michele Frison @frisophagy.bsky.social · 9mo ago

Only good papers on mitophagy this week! biomed.news/bims-tofagi/... Highlights: -The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy -Piecemeal Mitochondrial degradation in plants -Allophagy?! Thanks to @biomednews.bsky.social

Altered bottleneck and mitochondrial turnover affect mtDNA mutation load and selection efficiency.
(A) Mutational burden was quantified as the total number of mtDNA variants detected per animal. (B) For each animal, the mtDNA N/S ratio was calculated by dividing the number of nonsynonymous variants, normalized to the number of possible nonsynonymous variants in the mitochondrial genome, by the number of synonymous variants, normalized to the number of possible synonymous sites. For (A) and (B): dashed line, median value of the Polg+/+ control group; dotted line, modal value of the Polg+/+ control group; gray, Polg+/+ control group; orange, Polg+/+ Tfam+/− group; blue, Polg+/+ Tfam+/OE group; green, Polg+/+ Bcl2l13−/− group; and pink, Polg+/+ Ulk2−/− group.

Michele Frison @frisophagy.bsky.social · 9mo ago

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy | Nature

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature

Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...

nature.com

Michele Frison @frisophagy.bsky.social · 9mo ago

Mitophagy updates of last week 🪫🗑️ biomed.news/bims-tofagi/... Highlights: -two papers on the beneficial effects of mitophagy in CD8+ T cells -VPS35 mutations in PD affect PINK1/Parkin mitophagy selectively -review on selective autophagy initiation Thanks to @biomednews.bsky.social for pre-sorting

Left, soluble SARs such as SQSTM1/p62, NDP52, OPTN, TAX1BP1, and NBR1 are cytosolic proteins that are recruited to cargo on demand. Their recruitment is commonly driven by ubiquitin (Ub) marks on damaged or misfolded cargo, enabling rapid and flexible targeting of diverse substrates. Upon recruitment, these SARs concentrate autophagy initiation factors at the cargo site to initiate autophagosome biogenesis. Right, transmembrane SARs such as NIX, BNIP3, FAM134B, and CCPG1 are stably integrated within organelle membranes. To prevent unwanted autophagy activation, these SARs require additional layers of control. Selective autophagy can be triggered by transcriptional upregulation (e.g., hypoxia-driven induction of NIX/BNIP3), post-translational modifications such as ubiquitination, or SAR clustering. ER-phagy SARs further promote local membrane bending and scission to excise a portion of the organelle for autophagic removal. While some SARs are transcriptionally induced, others—such as FAM134B—are constitutively present and rely primarily on clustering and post-translational regulation, providing SAR-specific modes of control over autophagosome formation.

Christian Frezza @frezzalab.bsky.social · 9mo ago

Wonderful work from @mito-oncogene.bsky.social and @edreznik.bsky.social on the role of mito ribosomal RNA in cancer.

Payam Gammage@mito-oncogene.bsky.social · 9mo ago

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask? rdcu.be/eN1jm

Michele Frison @frisophagy.bsky.social · 9mo ago

In this week's issue of mitophagy news 🗑️🪫 biomed.news/bims-tofagi/... -High sugar diet inhbits renal mitophagy and disrupts renal function -a review by @soleimanpourlab.bsky.social on mitophagy in diabetic ß-cells -Optineurin is necessary for mitochondrial removal during erythrocyte maturation

Assessment of mitophagy in the Malphigian tubules of the dmt-Keima Drosophila kidney

Scott Soleimanpour @soleimanpourlab.bsky.social · 10mo ago

New from us! Had a question about mitophagy but were afraid to ask? 😂 Excited to review the latest advances in beta cell mitophagy research as a key adaptive response in all forms of diabetes in @cp-trendsendomet.bsky.social. We'd be honored if you have it a read! #T1D #T2D

Trends in Endocrinology and Metabolism@cp-trendsendomet.bsky.social · 10mo ago

Online Now: Mitophagy in the adaptation to pancreatic β cell stress in diabetes #trends #endocrinology #metabolism

Oded Rechavi @odedrechavi.bsky.social · 10mo ago

Here's the link to the system, try it! qedscience.com @qedscience.bsky.social

q.e.d Science

Critical Thinking AI for constructive criticism and science evaluation

qedscience.com

Jack Collier @mitocollier.bsky.social · 10mo ago

🔥 Check out our new paper! @natcellbio.nature.com Also thanks to @embo.org for their Postdoctoral Fellowship and especially to Mai and Heidi, I learned more than I could ever have imagined in Montreal 🇨🇦 🍁

Heidi M McBride@mitodynamics.bsky.social · 10mo ago

New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org. rdcu.be/eKKz1 🇨🇦

Euromit-2026 @euromit-2026.bsky.social · 10mo ago

📢 Check out this exciting new study by Professor Patrick Chinnery from @mrc-mbu.bsky.social, who will be joining #Euromit2026 as keynote speaker! pubmed.ncbi.nlm.nih.gov/41066576/ #MitochondrialDisease #mtDNA #mitochondria #euromit2026 @ua-recherche.bsky.social @chuangers.bsky.social

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations - PubMed

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

pubmed.ncbi.nlm.nih.gov

Johannes Zuber @johanneszuber.bsky.social · 10mo ago

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Michele Frison @frisophagy.bsky.social · 10mo ago

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease? This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility. www.science.org/doi/10.1126/...

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations

science.org

Scott Soleimanpour @soleimanpourlab.bsky.social · 10mo ago

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔 In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n www.science.org/doi/10.1126/...

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy

TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.

science.org

Michele Frison @frisophagy.bsky.social · 10mo ago

In this week's mitophagy news 🪫🗑️ biomed.news/bims-tofagi/... ⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡ -Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway Thanks to @biomednews.bsky.social

PP2A-B55α activates TFEB upon mitochondrial damage to support Parkin-dependent mitophagy.

Mongabay @mongabay.com · 10mo ago

Jane Goodall, who revealed the intimate lives of chimpanzees and gave the modern world a language of hope, has died at the age of 91. “Every individual matters. Every individual has a role to play. Every individual makes a difference,” she told audiences. Those words remain her truest epitaph.

Jane Goodall (1934–2025): primatologist, conservationist, and messenger of hope

Jane Goodall, who revealed the intimate lives of chimpanzees and gave the modern world a language of hope, has died at the age of 91. Over the course of six decades, she moved from an unlikely young…

news.mongabay.com

Michele Frison @frisophagy.bsky.social · 10mo ago

Lots of interesting papers in this week's mitophagy news! 🗑️🪫 biomed.news/bims-tofagi/... -Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity -Pink1 KO leads to APP-induced dopaminergic pathology -An OMM-rupture sensor

Anupam Patgiri @apatgiri.bsky.social · 11mo ago

Replication competition drives the selective mtDNA inheritance in Drosophila ovary www.cell.com/cell-reports...

Replication competition drives the selective mtDNA inheritance in Drosophila ovary

Zhang et al. report a novel imaging method that can distinguish mtDNA variants with single-nucleotide polymorphisms at single-molecule resolution in situ. Using this method, they visualized dynamics o...

cell.com

Michele Frison @frisophagy.bsky.social · 11mo ago

In this week's issue of mitophagy news 🪫🗑️: -Urolithin A increases healthspan via MERCS and Ca2+-mitophagy -Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity -a Parkin and hTau mouse cross biomed.news/bims-tofagi/...

Urolithin A ameliorates the age-dependent decline of ER-mitochondria contacts and alters intracellular Ca2+ balance.

Michele Frison @frisophagy.bsky.social · 11mo ago

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations | Science www.science.org/doi/10.1126/...

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations

Somatically acquired mitochondrial DNA mutations accumulate with age, but the mechanisms and consequences are poorly understood. Here we show that transient injuries induce a burst of persistent mtDNA...

science.org

Nikita Kozhushko @nikitakozhushko.bsky.social · 11mo ago

Celebrating Postdoc Research – National Postdoc Appreciation Week 2025! #PostdocAppreciationWeek #PostdocResearch #CIMR #MBU #Cambridge #ResearchSeminar #ScienceCommunication #CambridgeUniversity