“Never delegate understanding.” That quote stuck with me—and it’s now the title of my new Substack. I’ll be writing about health, science, & how these things can be understandable. Subscribe here → neverdelegateunderstanding.substack.com/subscribe #health #science #medicine @yalemed.bsky.social

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Making health and science understandable. Click to read Never Delegate Understanding, by Harlan Krumholz, a Substack publication. Launched 2 days ago.

neverdelegateunderstanding.substack.com

A JAMA study examined lifestyle interventions' effects on cognitive function in older adults at risk of cognitive decline and dementia. Lead author Laura Baker, PhD, from @wakeforest.bsky.social shared key insights with several media outlets. 🧵 ja.ma/4lQmvFu #AAIC2025

Aiming for 7,000 daily steps can reduce risk of chronic diseases, cognitive decline, and death, finds new study. Explore the research in @thelancetph.bsky.social: tinyurl.com/mrvd9uyt

A brilliant article by @rmcelreath.bsky.social . I had not heard of ‘bread scientists’ before but see them everywhere. Related to the strong case for teaching reliable, rigorous methods, I see as a major problem the selection of “optimistic” stat methods. #StatsSky #EpiSky

Richard McElreath 🐈‍⬛@rmcelreath.bsky.social · last yr.

How can we reform science? I have some ideas. But I am not sure you’ll like them, because they don’t promise much. elevanth.org/blog/2025/07...

While sedentary behavior among US adults decreased from 2013 to March 2020, this trend stalled from 2021 to 2023. https://ja.ma/4nWVKRg

Researchers have been sneaking secret messages into their papers in an effort to trick AI tools into giving them a positive peer-review report Read the full story: www.nature.com/articles/d41...

Our new JAMA Cardiology study finds that many US adults don't know that they have hypertension, diabetes, or high cholesterol Nearly 1 in 3 young adults w/ hypertension, 2 in 5 with diabetes, and 1 in 4 with high cholesterol are unaware of their condition. bit.ly/45an6MC #medsky #cardiosky

Hypertension, Diabetes, and High Cholesterol Awareness Among US Adults

This cross-sectional study evaluated the changes in the proportion of US adults who were unaware they had hypertension, diabetes, or a high cholesterol level using 2013 to 2023 data from the National ...

jamanetwork.com

Interesting thesis in the latest issue of Hypertension @ahascience.bsky.social @ahajournals.bsky.social Additional support for multiclass approach to hypertension management. www.ahajournals.org/doi/abs/10.1...

Are Diuretics a Clandestine Risk Factor for Patients With Treatment-Resistant Hypertension? | Hypertension

The control of blood pressure in patients with treatment-resistant hypertension is paramount and requires the use of thiazide or loop diuretics to enhance renal salt excretion and reduce expanded body...

ahajournals.org

On social engagement and healthy aging. open-access "High social engagement was associated with lower mortality risk than low engagement (a-HR:0.58) agsjournals.onlinelibrary.wiley.com/doi/10.1111/...

#EuroPCR #JACC LBCT: #FFR-guided complete #revascularization reduced future and repeated events compared with infarct-related artery only after 10 years. The risk was mainly driven by revasc, with no reduction in MIs or death. www.jacc.org/doi/10.1016/... #cvMI #revasc

10-Year Outcome of Complete or Infarct–Artery-Only Revascularization in STEMI with Multivessel Disease (DANAMI-3-PRIMULTI):

jacc.org

When should you take your blood pressure medication? A new randomized trial shows no difference bedtime vs morning @jama.com jamanetwork.com/journals/jam...

Antihypertensive Medication Timing and Cardiovascular Events and Death

This randomized clinical trial assesses the effect of bedtime vs morning administration of antihypertensive medication on the rate of all-cause death or major cardiovascular events among patients with...

jamanetwork.com

Consistent with results of 4 other randomized trials

Reducing the risk of all-cause dementia with intensive blood pressure control, the results of a cluster randomized trial in~34,000 participants. @naturemedicine.bsky.social www.nature.com/articles/s41...

Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial - Nature Medicine

In the CRHCP-3 cluster-randomized trial, blood pressure reduction lowered the risk of all-cause dementia by 15% in 33,995 individuals with hypertension.

nature.com

One of my outstanding mentees will presenting our angina findings from the RESILIENT trial at #ACC25. #CardioSky

The number of geriatricians is shrinking, just 7,400 in 2022, down from 10,000 in 2000, while the aging population keeps growing. The American Geriatrics Society says we’ll need 30,000 by 2030. The math isn’t adding up!

America's aging population faces a growing shortage of geriatric care

For a variety of reasons, geriatric care experts told BI it's been hard attracting new doctors to the field. It's a problem for an aging US population.

businessinsider.com

#ACC25 is just around the corner! Our Health Policy Team will be presenting timely research on the effects of private equity acquisitions, telehealth parity policies, & the Inflation Reduction Act on cardiovascular health Come by to check out this amazing group of trainees work! #cardiosky

This is a neat study with implications for high-throughput community screening: Accuracy of a Novel High-Throughput “Car Blood Pressure” Measurement Protocol academic.oup.com/ajh/article-...

Accuracy of a Novel High-Throughput “Car Blood Pressure” Measurement Protocol

AbstractBackground. More than one in three adults with hypertension in the United States are unaware of their condition, highlighting the importance of lar

academic.oup.com

One little problem for the dimension of Superhumans with extended longevity: no data. @economist.com www.economist.com/briefing/202...

Important to do studies like this in our older patients: www.acc.org/latest-in-ca... #CardioSky

Does Tafamidis Improve Survival For Octogenarians With Wild-Type Transthyretin Cardiac Amyloidosis? - American College of Cardiology

acc.org

Stepped-Wedge Cluster Randomized Trial??? What on earth is that????!!!! A complicated study design in which an intervention is rolled out at different times across sites Excellent article will help you understand and make sense of this design. jamanetwork.com/journals/jam...

What Is a Stepped-Wedge Cluster Randomized Trial?

This Guide to Statistics and Methods describes design, interpretation, and examples of a stepped-wedge cluster randomized trial.

jamanetwork.com

Who funds biomedical research? @nature.com www.nature.com/articles/d41...

New example of opportunistic A.I. in medicine Get a liver diagnosis from an echocardiogram ai.nejm.org/doi/full/10.... @cedarssinai.bsky.social @ai.nejm.org

Opportunistic Screening of Chronic Liver Disease with Deep-Learning–Enhanced Echocardiography

Chronic liver disease (CLD) affects more than 1.5 billion adults, most of whom are asymptomatic and undiagnosed. Echocardiography is broadly performed and visualizes the liver, but this information...

ai.nejm.org

This is an important @nytimes.com piece on Geriatric Cardiology and how we need to think differently when caring for our older cardiac patients: www.nytimes.com/2025/02/15/h... #CardioSky

New Insights Into Older Hearts

Heart disease is more common in people over 65, but treatments are better than ever. That can complicate decision-making for older heart patients.

nytimes.com

Great conversation with Dr. Blachman today on SiriusXM about healthy cardiovascular aging. Our NYU Geriatric Cardiology Program is celebrating its 10th year! ❤️ #CardioSky #Geriatrics #MedSky

How to get 146% return on investment? The NIH. That's just the economic benefit. Biomedical research promotes human health.

Massive NIH cuts to research infrastructure threaten the foundation of U.S. research—putting our future at risk. We need innovation in funding, not dismantling our research engine. My take in @statnews: www.statnews.com/2025/02/08/n...

The NIH’s drastic cut to indirect cost rates is a critical threat to U.S. research infrastructure

The drastic reduction in indirect costs is not a path to innovation or cost savings — it’s a threat to U.S.’s position as global leader in medical research.

statnews.com

This 👇 www.acc.org/latest-in-ca... #CardioSky @accintouch.bsky.social

The BMJ will always be the funniest journal 😂 #CardioSky #MedSky

🚨 NEW in @JACCJournals: Despite global initiatives, 2° prevention medication use in CVD stagnant or declining in most income-level groups. 12-year study across 17 countries. We must do better! 📉💔#HealthEquity @ACCinTouch #PURE Read the full study 👉 www.jacc.org/doi/10.1016/...

Preventing cognitive decline through lifestyle intervention, results of a large randomized trial www.nature.com/articles/s41... Conducted online, 4 modules, personalized, targeting physical activity, nutrition, cognitive activity, depression/anxiety, in at-risk individuals, mean age 65 years