Jarrod Dudakov
@dudakov-lab.bsky.social
Immunology with a touch of regenerative medicine (or is it the other way around?). Thymus enthusiast at Fred Hutch (previously seen around Monash Uni & Sloan Kettering Institute) 🇦🇺 in 🇺🇸
#For #TCR #Lovers look at this #great paper @pgtimmune.bsky.social Uneven TCR chain pairing constraints govern epitope recognition | Science www.science.org/doi/10.1126/...
Uneven TCR chain pairing constraints govern epitope recognition
Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope reco...
science.org
Our lab anticipate having #two #postdoctoral #positions starting beginning/late summer #2027. We are searching for candidates with #Tcell #expertise #protein #engineering and #ThymicTcellDevelopment.
🚨If you are a CA resident, please be aware of Prop 38, which is on the ballot this Nov. This initiative will provide $8.4 billion to advance breakthrough immunology research and treatments w/ half the funds dedicated to Alzheimer’s, cancer, and heart disease 1/
And again with the Second year hate. Hard on programs with a rotation year.
Joshua Weitz@joshuasweitz.bsky.social · 2w agoNSF just announced its GRFP solicitation due in October - deadline varies by field: www.nsf.gov/funding/oppo... Now for the bad news... * NSF estimates they will issue 1,500 awards, down from 2,500+ last year. * NSF removed STEM Education and Learning Research as a Major Field.
More validation for how critical health of the thymus is in adults, as assessed by AI of a chest CT. Thymus radiation exposure is linked to worse outcomes for cancer (non-small cell lung cancer) for distant metastasis and reduced survival annalsofoncology.org/article/S092...
Thymic radiation is associated with worse outcomes in patients with NSCLC
Emerging evidence indicates the functional importance of the thymus in adult health and may influence oncological outcomes, yet current radiotherapy (RT) practice does not consider the thymus as an or...
annalsofoncology.org
Central T cell tolerance from sparse peptide sampling www.science.org/doi/10.1126/... @hannahvmeyer.bsky.social @cshlnews.bsky.social
Simpsons: Homer and Bart Say 'Join Us'
ALT: Simpsons: Homer and Bart Say 'Join Us'
static.klipy.com
Fred Hutch@fredhutch.org · 3w ago🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @basicsci.fredhutch.org. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: https://apply.interfolio.com/190640
What transparency! Now every application below 25th %ile (but really 50th) is in the lottery! Taken with all other shenanigans, who is making funding decisions and on what grounds is going to become literally impossible to determine.
Elizabeth Sypek@elizabethis.bsky.social · 4w agoFriday drop grants.nih.gov/grants/guide...
He is not CDC (acting) director anymore; I say again, where the hell is the CDC in all of this????
Aaron Rupar@atrupar.com · 4w agoFOX NEWS: Will dropping the number of vaccines that people are advised to receive from 18 down to 11 lower the instances of autism in America? BHATTACHARYA: I don't know the answer to that question. It's something we're studying actively at NIH. We're not taking vaccines away from anybody.
Anyone heard a peep from the new CDC Director? She was touted as a rational vaccine proponent so perhaps now would be a good time for her to weigh in.
This will probably not receive as much attention as some things but this is truly catastrophic. Limiting the K99 to US citizens and Green card holders will be a huge blow to scientific innovation in this country - it is how so many of us got our starts here. I for one would not be here without mine
STAT@statnews.com · last mo.The NIH plans to close the door on one of the few pathways available to international students on visas to forge a career in biomedical research in the U.S. www.statnews.com/2026/08/07/n...
Second Annual Dudakov Summer Lab Olympics in the bag. Challenges included: calculations of solute concentration; speed BSL2 PPG dressing; read the tiny hidden text under the microscope; blindfolded pipetting; and Gatorade mouth pipetting. Great day and amazing organization by Emma Lederer.
Ellen is truly an amazing scientist and extremely generous with her time and support. An inspiration to all.
Itai Yanai@itaiyanai.bsky.social · 2mo ago‘Inhabiting the data’ is how CalTech Professor Ellen Rothenberg describes her process for coming up with a new idea, in the very first episode of the Night Science Podcast. (@nightsciencepod.bsky.social)
Hard for me to believe but we had a beach day to celebrate the labs 10th anniversary (and promotion to full Professor). What a fantastic group of people (past and present) who have made it possible!
What if the next breakthrough never comes? The trailer for The Endless Frontier, a new documentary, by two time Emmy Winning Director Marilyn Ness. @nycures.bsky.social @standupforscience.net @aai.org @aaas.org @nature.com @sciam.bsky.social @statnews.com www.youtube.com/watch?v=rZ6s...
The Endless Frontier (2026) - Official Trailer
YouTube video by Endless Frontier Film
youtube.com
Several people have asked for possible content and structure for comments regarding the proposed OMB regulations. With some suggestions from others, I have posted on example (as a Word document) for downloading). jeremymberg.github.io/jeremyberg.g... I hope this is helpful.
jeremymberg.github.io
If you are going to comment on the proposed changes to how science is done in the US, please use this guide. The rules specify that you have to mention the number associated with the proposed changes, and this blog has those. Here is where to comment: www.federalregister.gov/documents/20...
Regulation for Federal Financial Assistance
The Office of Management and Budget (OMB) proposes to revise the Guidance for Federal Financial Assistance to improve government- wide policies and requirements related to the management of grants, co...
federalregister.gov
Susana Wadgymar🌿🔬@smwadgymar.bsky.social · 3mo agoHere's a summary of what is being proposed: elizabethginexi.substack.com/p/summary-of...
Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis. New study from Jie Li, Yousuke Takahama (National Cancer Institute) and colleagues: rupress.org/jem/article/... #MucosalImmunology #LymphocyteBiology #TCells #Thymus
Online now: Aged circulating CD8+ T cells and their secreted factors drive cognitive decline
Aged circulating CD8+ T cells and their secreted factors drive cognitive decline
The role of non-infiltrating aged CD8+ T cells in brain function remains unclear. Sucharov et al. reveal that aged circulating cytotoxic T cells are drivers of age-related cognitive decline. Removal of aged T cells, or their secreted factor granzyme K, rescues cognition in mice. These findings have promise for therapeutics that target immune factors in circulation to restore brain function.
dlvr.it
Join us on Oct. 8-9 in Seattle for this unique opportunity to explore careers in #immunology, #oncology and #datasciences at Fred Hutch. Food, lodging and travel covered! Apply by June 1: https://bit.ly/4mhE8yX
Hennings, Ekwall et al. integrated spatial transcriptomic and proteomic analyses of #thymus tissue from patients with 22q11.2 deletion syndrome to identify fibroblast-driven collagen expansion and alterations in medullary niches. rupress.org/jhi/article/... #InbornErrorsOfImmunity
For decades, a mysterious, two-lobed organ nestled behind the breastbone has been overlooked by most physicians. Now, research is recasting it as a potent regulator of aging and immune health across the lifespan.
The body’s most mysterious organ may play a key role in longevity and cancer
A raft of research is recasting the thymus from a bit player to a potent regulator of aging and immune health.
washingtonpost.com
In a new study from Tan, Kergaravat, @petterbrodin.bsky.social et al., longitudinal profiling of 136 newborns shows thymic output peaks at 3–4 mo, correlating with plasma RANKL, lymphotoxin-α, and the TCRD variant rs2204985. rupress.org/jhi/article/...
www.nature.com/articles/s41... 📢 Check out our article in its final format in @natcomms.nature.com Unbiased recording of thymic cellular interactomes via synthetic Notch receptors #synNotch #Tcells #thymus #syntheticbiology @qmbci.bsky.social
Unbiased recording and identification of thymic cellular interactomes using synthetic Notch receptors - Nature Communications
Interactions with haematopoietic and stromal cells in the thymus are essential for T cell development. Here, the authors develop an unbiased genetic system based on synthetic Notch receptors to label ...
nature.com
KLF2 is a critical regulator of thymic epithelial cells homeostasis and preventor of autoimmunity www.sciencedirect.com/science/arti... @cp-iscience.bsky.social
Your Thymus and Your Healthspan erictopol.substack.com/p/your-thymu... Plus: can we rejuvenate our thymus?
Your Thymus and Your Healthspan
New landmark studies using AI to determine thymus health and its link to major outcomes
erictopol.substack.com
Wow. Multiple papers showing clinical relevance of thymus function for lifelong health and immunotherapy outcomes. Like music to my ears! www.nature.com/articles/d41... www.nature.com/articles/s41... www.nature.com/articles/s41...
Thymus health is a predictor of lifelong well-being and immunotherapy effectiveness
It was thought that the thymus serves its purpose for the immune system early in life. Insights about the organ in adults reveal its importance for later well-being.
nature.com
