Congratulations Annie @anniegallagher.bsky.social for a wonderful thesis defense. Thanks also to @alexisbarr.bsky.social and Elena Bochukova for being the examiners.

🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...

Audrey, superstar postdoc in my lab is sadly moving on but not before seeing her first author work published! www.linkedin.com/posts/audrey...

Replication origin firing capacity indicates ATR inhibitor sensitivity - Nature Communications | Audrey Lumeau

We are thrilled to share that our latest work has been published in Nature Communications! 🎉 In our study, we identify replication origin firing capacity as a key determinant of cellular sensitivity ...

linkedin.com

Delighted to post (after quite a hiatus) our latest published work trying to get to the bottom of why some cancers respond to ATR inhibition and some don’t care www.nature.com/articles/s41...

Today, on #WorldCancerDay, we’re taking you behind the scenes at Queen Mary's Barts Cancer Institute and introducing you to the people who are making progress possible. Follow us to stay up to date with new developments. 🧪 #UnitedByUnique #MedSky #OncoSky @qmul.bsky.social @cancerresearchuk.org

Driving discoveries for tomorrow's cancer care at Barts Cancer Institute

YouTube video by BCIQMUL

youtu.be

We are recruiting a Postdoc in computational biology, together with @mariasecrier.bsky.social 4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence Applications open now: www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

imperial.ac.uk

www.nature.com/articles/s41...

A breakage–replication/fusion process explains complex rearrangements and segmental DNA amplification - Nature Genetics

This paper introduces breakage–replication/fusion, a genomic rearrangement process underpinning three patterns of copy-number gains found in cancer and other diseases.

nature.com

4 months ago I boasted of two papers accepted in two days. In the interests of transparency I should also post that this week we had two papers rejected (or stalled). I wish this process was a little less demoralising, it’s the most important thing we have to do!!! Be nice people!

www.sanger.ac.uk/news_item/or...

Order of cancer-driving mutations affects the chance of tumour development

Scientists reveal that mutation order influences tumour growth in the intestine.

sanger.ac.uk

Arriving at work. That’s the moon.

So proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍 The mighty yeast reveals what we believe are general principles of centromere evolution! Behind the curtain: communities.springernature.com/posts/counti... #MEvoSky 🧪🌎

Counting Chromosomes: The Simple Idea That Unlocked the Rules Behind Centromere Evolution

communities.springernature.com

Jana Helsen@helsenjana.bsky.social · 8mo ago

How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1

We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you. Application deadline: 24 December www.crick.ac.uk/careers-stud...

A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration. www.nature.com/articles/s41...

Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time www.nature.com/articles/s41...

Engineered chromatin readers track damaged chromatin dynamics in live cells and animals - Nature Communications

DNA damage threatens genome stability, but its dynamics in living systems remain difficult to track. Here, the authors engineer MCPH1-based protein probes that specifically recognize γH2AX, enabling r...

nature.com

Lab website has been updated including a very nice news section! Www.mcclellandlab.com/news

Ready to start your own independent research programme? We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk Apply by 27 Nov 2025: www.crick.ac.uk/careers-stud... #EarlyCareerResearchers #GroupLeader #ScienceCareers

Early career group leaders

We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

crick.ac.uk

The Francis Crick Institute@crick.ac.uk · 10mo ago

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...

Senior Research Technician at University of Birmingham

Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

jobs.ac.uk

3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries lnkd.in/etU3yydb

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026. Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years. Find out more: www.jic.ac.uk/training-car...

Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre

The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…

jic.ac.uk

Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...

2026 BLiC PhD Project Soliman

Targeting a cell cycle vulnerability in TP53 mutant cancers Primary supervisor: Tanya Soliman, Queen Mary University of London Secondary supervisor: Miraz Rahman, King's College London Project To ...

colcc.ac.uk

Cancer Research UK City of London Centre@cruk-cityoflondon.bsky.social · 10mo ago

Are you interested in doing a #PhD in #cancerresearch? 🧪👩🏿‍🔬🧫🦠🔬 Do you want to develop new #biotherapeutics? Are you of black heritage? Applications for our fully funded 4-year BLiC PhD programme starting in Autumn 2026 are open now! bit.ly/485QAga #uclcancer #QMBCI #KCLcancer_pharm #KCL #TheCrick

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

Investigating the interplay between DNA damage repair mechanisms, genomic instability and radiotherapy resistance - CRUK RadNet

Investigating the interplay between DNA damage repair mechanisms, genomic instability and radiotherapy resistance Primary supervisor: Sarah McClelland, Queen Mary University of London Secondary superv...

crukradnet.colcc.ac.uk

CRUK Radiation Research City of London Centre @cruk-rrc-col.bsky.social · 10mo ago

Interested in carrying out research in cancer Radiotherapy and Radiobiology? Applications are open now for our PhD programme for 2026 intake! @kingscollegelondon.bsky.social @qmbci.bsky.social @crick.ac.uk @ucl.ac.uk crukradnet.colcc.ac.uk/phd-students...

Our first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social

Last day of the @theaacr.bsky.social Advances in Pancreatic Cancer Research Conference in Boston! Yesterday I presented my poster on genome evolution & chemoresistance in PDAC, from @mcclellandlab.bsky.social. Thanks for the great feedback — and to @pancreaticcanuk.bsky.social for the opportunity!

Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.

Professors x 10, Faculty of Medicine & Dentistry | Veredus

QUEEN MARY UNIVERSITY OF LONDON Professors x 10, Faculty of Medicine and Dentistry London Competitive Remuneration Package Queen Mary University of London seeks up to 10 world-leading translational re...

veredus.co.uk

Dosage responses of aneuploid autosomal chromosomes https://www.biorxiv.org/content/10.1101/2025.09.18.677044v1

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

imperial.ac.uk

Please visit our newly refreshed and updated website mcclellandlab.com We seem to be hard to find on Google for some reason, any tips from website savvy people?? 🙏

Checkout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells

Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

rdcu.be

Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs www.cell.com/cell-reports...

ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin

The ARID1A subunit of the BAF chromatin remodeling complex is frequently mutated in cancer. Simões-Sousa et al. demonstrate that ARID1A promotes the assembly of repair factors on chromatin and promote...

cell.com

The Downs Lab@thedownslab.bsky.social · last yr.

New preprint from the lab on ARID1A, G quadruplexes, and repair: www.biorxiv.org/content/10.1...

Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...

Learning the cellular origins across cancers using single-cell chromatin landscapes - Nature Communications

Understanding the cellular origins of cancers is crucial for improving diagnosis and treatment. Here, the authors utilize single cell chromatin accessibility data, patient whole-genome sequencing muta...

nature.com