Selin Jessa
@selinjessa.com
(she/her) Computational biologist and post-doc scientist in the Greenleaf and Kundaje labs at Stanford. Interested in understanding how cells know what to become (transcription factors, gene regulation, dev bio, open science) www.selinjessa.com
Love science, teaching genetics, and mentoring? There are some great students and faculty at @smithcollege.bsky.social and they are hiring a tenure track assistant professor! Some of my favorite folks in #DevBio are there! www.smith.edu/people/cagne... www.smith.edu/people/micha...
George O'Toole (he/him/his)@geiselbiofilm.bsky.social · 5d agoPls share. Assistant Professor of Biological Sciences - Genetics/Genomics at Smith College. apply.interfolio.com/190342
New post on the @cosmik.network blog: who ever heard of bookmarks that can help *shorten* your reading list? On how bookmarks, combined with social curation networks like @semble.so, can be much more than bookmarks - they can be sensors! blog.cosmik.network/sensors-not-...
Sensors, not just bookmarks [Patterns of Sensemaking #1]
First of a new series on sensemaking patterns we're observing on Semble
blog.cosmik.network
Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/
An encyclopedia of human enhancer–gene regulatory interactions - Nature
An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...
nature.com
My department, Neurobiology and Biophysics at the University of Washington (nbio.uw.edu), is hiring a new tenure-track Assistant Professor, application deadline 09/30/26. It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome. apply.interfolio.com/187735
Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...
Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers
Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac...
biorxiv.org
Great experience compiling years of collective screening experience to produce what we hope is a comprehensive protocol for others to accessibly scale up experiments! And some fun new data hidden in there :) @joshtycko.com www.nature.com/articles/s41...
High-throughput measurements of protein domain functions using magnetic separation - Nature Protocols
This Protocol presents a scalable magnetic separation-based method for screening large protein domain libraries in mammalian cells, providing a simple and quantitative alternative to fluorescence-acti...
nature.com
Our latest is out in Nature Genetics with @soumyakundu.bsky.social @anshulkundaje.bsky.social and @sbmontgom.bsky.social ! We built a resource of predicted variant effects on chromatin accessibility, and FLARE to identify disease variants with extreme effects. www.nature.com/articles/s41...
Decoding common and rare noncoding variant effects across cellular and developmental contexts - Nature Genetics
This study contributes a resource of predicted effects of noncoding variants on chromatin accessibility and a method to identify noncoding variants with extreme regulatory effects, with application to...
nature.com
My colleague @guipingwang.bsky.social will soon be launching her lab at the CRUK combining imaging and gene regulation - check it out for fully-funded PhD opportunities!
Guiping Wang@guipingwang.bsky.social · 2mo agoIf you are intrigued by principles of gene regulation not only at the cellular level but also at the subcellular level... my lab at the CRUK Cambridge Institute is recruiting highly motivated PhD students with Jan 2027 start! 4-year fully funded, UK + intl welcome (1/5)
Last call for our open Group Leader position at VIB.AI and Ghent University! Focus: AI in (bio)medicine Don’t miss this opportunity 👉 https://vib.ai/en/group-leader-vacancy
Do you know any students who are planning to apply to graduate school this cycle? Encourage them to apply to the Biology Preview Program! We provide intensive workshops to help students w/ their applications + 1:1 mentorship.
Please repost: My department at USC is hiring for a teaching-track faculty position. We are looking for someone principally to teach statistics for biologists, but there will be opportunities for other courses in statistics & algorithms applied to biology usccareers.usc.edu/job/los-ange...
Full-Time, Teaching-Track Faculty Position in Quantitative and Computational Biology at USC
Learn more about applying for Full-Time, Teaching-Track Faculty Position in Quantitative and Computational Biology at USC
usccareers.usc.edu
This @anshulkundaje.bsky.social, Kyle Fahr and William Greenleaf paper is finally out, we've been following it for a while in its preprint form, phenomenal work. www.nature.com/articles/s41...
nature.com
We are so excited to see our work out in @nature.com! We present a multi-omic single-cell atlas of 12 organs in human fetal development, explore the enhancer landscape, use deep learning to infer rules of transcription factor activity, and interpret non-coding variants in complex traits: #GeneReg 🧬🖥️
John Greally@greally.bsky.social · 4mo agoThis @anshulkundaje.bsky.social, Kyle Fahr and William Greenleaf paper is finally out, we've been following it for a while in its preprint form, phenomenal work. www.nature.com/articles/s41...
Grateful to have the opportunity to publish this review with Xiao Peng in Annual Reviews. We set out the challenges and opportunities to use information in rare disease diagnostics from the 98.8% of the human genome that does not encode genes. www.annualreviews.org/content/jour...
Understanding the Role of Functional Noncoding Variation in Human Diseases with Lessons from Immunity
The advent of next-generation sequencing has expanded our understanding of the genotypic, pathobiological, and phenotypic spectrum of human disease, helping to inform more personalized patient care. Current clinical guidelines are prompting the generation of large volumes of clinical diagnostic genome sequencing data, but we remain unable to interpret variants found in the noncoding 98.5% of sequencing data. In this review, we discuss the known and emerging mechanisms by which noncoding variants cause human disease. Through the lens of immunity, we integrate insights from population genetics, evolutionary and functional genomics, and in silico strategies to propose a framework for identifying and characterizing potential disease-relevant noncoding variants with regulatory impact on gene expression. By tackling the assessment of this vast black box of missing genetic contributions to disease, we hope to improve diagnostic yields and clinical management for more unsolved patients.
annualreviews.org
@sara-altman.bsky.social and I recently got together to compare Claude Code and Posit Assistant for data analysis with a recent #TidyTuesday release! The recording is now live on YouTube: www.youtube.com/watch?v=7GI6...
Comparing Posit Assistant and Claude Code
YouTube video by Posit PBC
youtube.com
We launched a new Group Leader vacancy in our Center for AI & Computational Biology - VIB.AI @vibai.bsky.social - with a Professorship at Ghent University. Join us with your most creative AI+Biology research plan! Apply before 31st May vib.ai/en/group-lea...
Group leader vacancy
We are looking for a Group Leader in applied artificial intelligence in (bio)medical research at VIB.AI & UGent, Belgium
vib.ai
🚨Attention #postdocs! Applications for our Excellence Postdoctoral Fellows Program open on April 1. 👩🔬Are you an early career researcher interested in working at the interface of biology & physics? We offer a 3+ year position, generous resources, and mentoring opportunities! Apply: tud.link/y3djda
Interested in joining a dynamic, interdisciplinary research department? A call is open for Group Leaders at the UCL Laboratory for Molecular Cell Biology. Please submit your expression of interest by April 13, 2026. Further details here: www.ucl.ac.uk/work-at-ucl/...
Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org
Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you! 1/n
Job Details
my.corehr.com
A reminder that we are actively recruiting a geneticist to the Department of Genetics at Albert Einstein College of Medicine careers-einstein.icims.com/jobs/17847/a...
Einstein
careers-einstein.icims.com
In a world first, B.C. teen cured of rare disease through gene editing treatment. Ty Sperle cured of chronic granulomatous disease with a treatment known as “prime editing,” by Brenna Owen www.theglobeandmail.com/canada/briti... via @theglobeandmail.com
In world-first, B.C. teen cured of rare genetic disease
The 19-year-old, who lives in Kelowna, had been diagnosed with chronic granulomatous disease around age five, compromising his immune system
theglobeandmail.com
📢📢📢Lectureships at Bristol!📢📢📢 We're hiring 3 x lecturers (=assistant professor) in Biological Sciences, across the discipline. Great department, great colleagues, great building, great city Details here: www.bristol.ac.uk/jobs/find/de...
Principal investigator job alert @ircm.bsky.social! We are recruiting a new junior faculty member working in the field of cancer. Apply before February 22nd. Contact me if you have more questions. www.ircm.qc.ca/en/position-...
Research Unit Director – IRCM Cancer Research Center
Job reference code: IRCM-Cancer
ircm.qc.ca
Each summer, I lead a week-long creative retreat for environmental researchers & academics on Catalina Island. We develop your most ambitious project ideas. It's truly life-changing. Applications for the 2026 Storymakers fellowship are now open! Deadline is Feb 1. dornsife.usc.edu/wrigley/enga...
Storymakers Program - Wrigley Institute for Environment and Sustainability
Creating a more sustainable and environmentally just future for our planet and all who live on it
dornsife.usc.edu
🧬🎉Join us on Dec 17th for our last session of 2025! 🎉🧬Two fantastic talks on transcriptional regulation: 🔬JB Lalanne on developmental enhancers (and starting a lab in 2025?) 🔬 @rberrens.bsky.social on transposable elements in development 📋Register here: us06web.zoom.us/webinar/regi...
Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...
First paper from the lab is now online @natneuro.nature.com ! We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1
The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS
Nature Neuroscience - Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover...
rdcu.be
Margherita Zamboni@margheritazamboni.bsky.social · 8mo agoThrilled to share our new publication on the regulatory code of injury responsive enhancers in the CNS! www.nature.com/articles/s41... @ellorens.bsky.social @ki.se @natneuro.nature.com
Ledidi is a DNA design method that designs *edits* to a template while explicitly minimizing the number of needed edits. This allows you to build upon informative starting material, which our genomes are full of, and simply edit in the final touches, similar to an Instagram filter or video touch-up.
After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells. www.biorxiv.org/content/10.1...
Programmatic design and editing of cis-regulatory elements
The development of modern genome editing and DNA synthesis has enabled researchers to edit DNA sequences with high precision but has left unsolved the problem of designing these edits. We introduce Le...
biorxiv.org