A detailed molecular picture of protein folding during active translation https://www.biorxiv.org/content/10.64898/2026.07.03.736445v1

1/13 So excited to share our new preprint!! How do organelles pack together in a crowded cytoplasm? we know organelles interact via contact sites, but how does competition for space contribute to organelle morphology and interactions? @wallaceucsf.bsky.social www.biorxiv.org/content/10.6...

Have a look at my latest Research Highlight below, highlighting an article by @sferronovick.bsky.social and colleagues, which found an interesting role for a COPII protein in autophagy 👀 Original article: www.science.org/doi/10.1126/...

Coupling of cargo to the autophagy receptor is a critical step in ER-phagy

The lipid composition of the ER regulates the ability of Lst1/SEC24C to couple cargo to an autophagy receptor.

science.org

Nature Reviews Molecular Cell Biology@natrevmcb.nature.com · last mo.

New Online! COPII meets autophagy at the ER membrane

Excited to share our review article on cilia disassembly, published in @jcellsci.bsky.social. journals.biologists.com/jcs/article/.... We highlight how disassembly of cilia occurs, ...

Primary cilium disassembly – from mechanisms to roles in physiology and disease

Summary: This Review explains how recent advances have expanded our models of how, when and where primary cilia disassemble and discusses emerging roles of altered disassembly in disease.

journals.biologists.com

So honoured to be joining the Lister community. Huge thanks go to my wonderful hardworking little group, my scientific mentors @cilialab.bsky.social and @carter-lab.bsky.social and all those who have helped me along this journey! We celebrated with some ice-cream!

The Lister Institute of Preventive Medicine@thelisterinstitute.bsky.social · last mo.

We are more than delighted to welcome our new #ListerPrize2026 Fellows! These eight inspiring researchers are set to pursue ambitious biomedical science, thanks to our flexible funding. Bravo! 👏 Meet the new #ListerFellows (read thread) and repost ⤵️ lister-institute.org.uk/news/our-lis...

Tet Trim-Away: A conditional rapid protein degradation system for Tetrahymena thermophila https://www.biorxiv.org/content/10.64898/2026.05.29.728803v1

Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 3mo ago

The hidden rules behind mRNA transport. A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs. Read more: mrclmb.ac.uk/news-events/... #LMBNews @cellbiol-mrclmb.bsky.social 🧪

cryoCLEM of dopaminergic neurons from @lycasworks.bsky.social and Simon Erlendsson: doi.org/10.1083/jcb....

Ultrastructure of dopaminergic varicosities revealed by cryo-correlative light and electron microscopy

Lycas et al. develop a cryo-CLEM workflow to characterize the ultrastructure of dopaminergic varicosities. They resolve in situ structures of TRiC/CCT and

doi.org

Our story on RNA recognition by Egl-BicD is now published! Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work. Paper: www.nature.com/articles/s41... News & Views: www.nature.com/articles/s41...

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 3mo ago

The hidden rules behind mRNA transport. A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs. Read more: mrclmb.ac.uk/news-events/... #LMBNews @cellbiol-mrclmb.bsky.social 🧪

Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.

Carter Lab@carter-lab.bsky.social · 4mo ago

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social. Available now on BioRxiv: doi.org/10.64898/202...

Ennio@amicoennio.bsky.social · 3mo ago

New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

The third round is now open! I will be hosting a webinar with my colleagues on Monday 27 April at 1pm. To sign up please go to: shorturl.at/Vuwib International applicants are eligible to apply!

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 4mo ago

The LMB Rising Talent Fellowship is open for new applicants! Aimed at Black heritage scientists, the Fellowship offers a 3-year postdoctoral position beginning Oct-Dec 2026. Visit our website for more info: mrclmb.ac.uk/careers-and-... Please circulate this post to anyone who might be interested!

Meet our new ECR Representatives for the Proteostasis UK ECR Network! This team will be delivering a range of resources, events, and initiatives to support the career development of ECRs Sign up to the network to access exclusive opportunities for ECRs 👉 Join here: proteostasisuk.co.uk

Very cool probe to label doublet MTs and therefore centrioles across different species and set ups (from live imaging, STED and expansion)!😍 www.nature.com/articles/s41...

Development of the fluorescent probe CenSpark for labeling centrioles and cilia - Nature Chemical Biology

CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling selective live imaging of cen...

nature.com

I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...

I am delighted to be among this years winners awards from the Biochemical Society! The Early Career Award recognises the work I did during my PhD and postdoc, and hopefully signals a bright start for my new lab within the @astbury-bsl.bsky.social at the University of Leeds 💫

Biochemical Society@biochemsoc.bsky.social · 4mo ago

We are so proud of all our Biochemical Society 2027 Award winners. Visit our website to find out more about all of the deserving recipients #BiochemAwards 🧪 https://ow.ly/mZ6O50YIGo8

The metallopeptidase MATCAP1 preferentially binds microtubules with an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulin @kjverhey1.bsky.social, Puck Ohi and collaborators link.springer.com/article/10.1...

MATCAP1 preferentially binds an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulin - The EMBO Journal

Microtubules are cytoskeletal filaments with critical roles in cell division, cell motility, intracellular trafficking, and cilium function. In cells, subsets of microtubules are selectively marked by...

link.springer.com

It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬

Caitie McCafferty@computingcaitie.bsky.social · 4mo ago

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

Beautiful work from @computingcaitie.bsky.social and colleagues, showing the power of combining multiple approaches to studying complex in situ cell biology!

Caitie McCafferty@computingcaitie.bsky.social · 4mo ago

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel

Congrats to the @biochemsoc.bsky.social 2027 Award winners, including @helenfoster.bsky.social who has won an Early Career Research Award. Helen was a PhD student in Andrew Carter’s group in the LMB’s Structural Studies Division, and is now a Group Leader at the University of Leeds. #LMBalumni

Biochemical Society@biochemsoc.bsky.social · 4mo ago

Utilising in situ structural biology to uncover fundamental mechanisms of cytoskeletal regulation, we're excited to present Helen Foster with an Early Career Research Award in 2027! Helen's research on immune cell cytoskeletal remodeling could open new frontiers in molecular immunology.

Also in Issue 6: - Research Highlights on kinesin-1, Capicua & endosomal fission - Editorial on publishing costs - JCS-David Stephens Prize - Helene Knævelsrud interview - Microscopy in mitochondrial research - Review on microtubules in cardiac mechanobiology journals.biologists.com/jcs/issue/13...

65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵

Beautiful new study from @dyneinassembly.bsky.social lab on cilia recycling.

(GIRISH)MALI LAB@dyneinassembly.bsky.social · 4mo ago

Happy to share our latest work spearheaded by super talented PhD student Muyang Ren now out as a bioRxiv preprint. 'Motile ciliophagy promotes ciliary recycling under stress' www.biorxiv.org/content/10.6...

Happy to share our latest work spearheaded by super talented PhD student Muyang Ren now out as a bioRxiv preprint. 'Motile ciliophagy promotes ciliary recycling under stress' www.biorxiv.org/content/10.6...

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

Some live movies to show to show surface cilia and internalised ciliary rings

Some live movies to show to show surface cilia and internalised ciliary rings

Happy to share our latest work spearheaded by super talented PhD student Muyang Ren now out as a bioRxiv preprint. 'Motile ciliophagy promotes ciliary recycling under stress' www.biorxiv.org/content/10.6...