Are you interested in the nuclear envelope and are still lacking a dye for it? Try the lectin concanavalin A in #U-ExM! Together with @baukjeje.bsky.social, @gautamdey.bsky.social and @dudinlab.bsky.social and many collaborators sharing species with us we explored the versatility of this dye

Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦@dudinlab.bsky.social · last mo.

We wanted to share this asap for everyone to use ! This will remain a #preprint for the time being. We are happy to recieve feedback, hear whether or not ot works in your hands and continue to apply it across #eukaryotes as part of #ExÂME You want to know more : www.dudinlab.com/exame

An animal’s body is in constant conversation with itself — & HHMI Janelia scientists have built a way to listen in. WHOLISTIC simultaneously records real-time activity from nearly every cell in a living larval zebrafish, a 1st step in understanding more complex bodies like ours: bit.ly/4xMR1Ww.

(1/4) We are very excited to share our latest preprint from @sauer-lab.bsky.social: Mega Expansion Microscopy (Mega-ExM)! We combine iterative hydrogel expansion with whole-proteome NHS labeling and post-expansion immunostaining, reaching tunable expansion factors up to ~1500× in whole cells 🤯

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 2mo ago

Structural cell biology by mega-expansion microscopy https://www.biorxiv.org/content/10.64898/2026.08.05.743040v1

🔬🔦In our latest Imaging spotlight, @jclandoni.bsky.social takes us through his recent papers dissecting mitochondria organisation. Juan discusses why they needed to employ multiple imaging approaches to unveil events that had not previously been observed. focalplane.biologists.com/2026/07/21/p...

Pearling and directed trafficking as determinants of mitochondrial genome organization and network architecture - FocalPlane

Pearling and directed trafficking as determinants of mitochondrial genome organization and network architecture - News

focalplane.biologists.com

FINALLY a histogram in napari! ♥️

napari@napari.org · 3mo ago

*Finally*, napari gets a built-in histogram! It's still a work in progress but already *very* cool if we do say so ourselves, with live update based on the canvas and progressive, background update when computing on large full data.

Our kind of fireworks: fruit fly neurons stacked in a rapid succession of rainbow colors. This video shows a small sampling of the more than 135,000 neurons in a typical fruit fly's brain, imaged by researchers at our Janelia Research Campus using multicolor flipout technique 🎆

These stunning single-celled organisms can shape-shift & regenerate. Their trumpet-like shape inspired their name: stentor, after the herald in Greek mythology known for his booming voice. 📸: Confocal microscopy by Igor Siwanowicz, HHMI’s Janelia Research Campus

The once-obscure Danionella fish takes center stage as a model research organism in a major new project funded by the Howard Hughes Medical Institute. Learn more: https://scim.ag/3QFj4XM

One of the world's leading brain research centers is shifting away from fruit flies and toward a tiny, transparent fish. The goal: to understand how brains control the behavior of an animal or human. n.pr/4vV8dYM

Is a transparent fish the future of brain science? This center is betting on it

One of the world's leading brain research centers is shifting away from fruit flies and toward a tiny, transparent fish. The goal: to understand how brains control the behavior of an animal or human.

n.pr

Janelia is built for this moment. Starting today, we're taking on 2 big bets: cracking how a vertebrate brain generates behavior, & building AI-in-the-Loop Discovery — a new way of doing biology. Tiny transparent fish + one of neuroscience’s biggest questions? Let's go: hhmi.news/2BigBets

And so it begins! Day 1, Lecture 0 of the first DL for Microscopy Image Analysis course at @hhmijanelia.bsky.social. Slides from @florianjug.bsky.social, presented by our TA Federico Carrara. #dljanelia

Home microscope project - high NA Phase contrast with the fun Lowa objective Lomo inverted with the Lomo 1.25 NA water inversion phase contrast Need to add light source and camera and phase annulus

📢 We're recruiting AI Scientists at HHMI Janelia. I'm biased, but these are exceptional opportunities. You'd join as an independent scientist with access to excellent computational infrastructure, some of the best biological data in the world, and a vibrant collaborative environment.

Expansion microscopy rocks

Ultrastructure of dopaminergic varicosities revealed by cryo-correlative light and electron microscopy. New study from Matthew Domenic Lycas (@lycasworks.bsky.social), Simon Erlendsson et al. @ucph.bsky.social: rupress.org/jcb/article/... #Neuroscience #Organelles #StructuralBiology #cryoCLEM

Got my pictures back

This mesmerizing timelapse captures the nonstop motion inside an animal cell. Red/orange streaks are the growing ends of microtubules, tiny “highways” that can rapidly assemble and disassemble to move proteins & other molecules within the cell. 📸: Andy Moore, HHMI’s Janelia Research Campus

My first corresponding author 🔬🎸🦾 rupress.org/jcb/article/... Ever wonder what the ultrastructure of dopaminergic neuron presynaptic sites looks like? Using cryo-CLEM/ET we observed the wild changes that happen at these sites when the neurons fire or are more quiet. In the latest @jcb.org

Ultrastructure of dopaminergic varicosities revealed by cryo-correlative light and electron microscopy

Lycas et al. develop a cryo-CLEM workflow to characterize the ultrastructure of dopaminergic varicosities. They resolve in situ structures of TRiC/CCT and

rupress.org

In @jcb.org, @lycasworks.bsky.social, Erlendsson et al. @ucph.bsky.social develop a #cryoCLEM workflow to characterize the ultrastructure of dopaminergic varicosities. rupress.org/jcb/article/... #Neuroscience #Organelles #StructuralBiology #Microscopy

@lycasworks.bsky.social, Erlendsson et al. @ucph.bsky.social develop a #cryoCLEM workflow to characterize the ultrastructure of dopaminergic varicosities. rupress.org/jcb/article/... #Neuroscience #Organelles #StructuralBiology #Microscopy

www.protocols.io/view/cryo-ex... New protocol alert!! Cryo-expansion microscopy of C. elegans and Tardigrades using the high pressure freezer!

Cryo-Expansion Microscopy of C. elegans and Tardigrades

Cryo-Expansion Microscopy of C. elegans and Tardigrades. Expansion microscopy (ExM) improves imaging r. Read full protocol, steps, and materials on protocols.io

protocols.io

We're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below! @fbm-unil.bsky.social @unil.bsky.social

Juan C. Landoni@jclandoni.bsky.social · 6mo ago

The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI

Quantitative Imaging: From Acquisition to Analysis (QICM), April 6 - April 21, 2026 Thank you to all of the participants and vendors that supported the course! #cshlcourses #cshl Photo Credit: Max Brambach, Eva de la Serna, and Federico Gasparoli (2026 Teaching Assistants) @qiatcshl.bsky.social

So thrilled to be part of Quantitative Imaging @qiatcshl.bsky.social Such an amazing course and now we got a whole new generation of expansion microscopy enthusiasts!

@lycasworks.bsky.social showing expansion microscopy followed by some hands on expansion exercises.

The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI

Super Res Sunday! And we are doing all the techniques:)

Hari Shroff giving the QI keynote on structural illumination microscopy, adaptive optics and new biosensors. Wow!

Light sheet lab. We image anything from cells to plants to shrimp. @fedegasparoli.bsky.social @excitedemissions.bsky.social are running the machines!