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Edward Pimentel

@edwardpimentel.bsky.social

Stanford Postdoc (Soh Lab) 🧬 UW-Madison PhD (Martell Group) 🧪 Loves Chemistry, Books, Bread, Bikes and Plants. 🇺🇸 🇧🇦 🇷🇴 🇳🇱 🇸🇩 🇧🇪

23 Posts63 Follower168 Folgt
Edward Pimentel@edwardpimentel.bsky.social · 8h ago

Polizzi lab preprint just dropped! Big implications for the future of small molecule sensing: Jeffrey designed de novo proteins with conformational changes upon binding that can be read out optically! Read it now on bioRxiv: www.biorxiv.org/content/10.6...

De novo design of small-molecule-induced conformational change

Many biological proteins function by changing shape upon small-molecule binding. Here, we present a general strategy for designing de novo proteins that undergo small-molecule-induced conformational c...

biorxiv.org

Boston Protein Design and Modeling Club@bpdmc.org · yesterday

Next week, Jeffrey Chang from @nickpolizzi.bsky.social's lab will present cutting-edge work from a pre-print that just came out today! Wednesday, August 12th 2026, 7pm EDT in Room 6055, Longwood Center, @danafarber.bsky.social "De novo design of small-molecule-induced conformational change"

WARF (Wisconsin Alumni Research Foundation)@warfnews.bsky.social · 6d ago

We're looking for a technology transfer intern to: ✔️ Assist with licensing & IP projects ✔️ Participate in outreach activities ✔️ Conduct market research Visit our careers page to learn more and apply! #NowHiring

WARF Careers | Wisconsin Alumni Research Foundation

WARF helps steward the cycle of innovation with a team that includes intellectual property, commercialization, investment and engagement professionals.

warf.org

Edward Pimentel@edwardpimentel.bsky.social · 6d ago

Fresh from the Soh lab: using a high-throughput aptamer screening platform to design non-intuitive split aptamers that challenge the traditional approach to split design. Bonus: this Lettuce won't give you cyclosporiasis. 🥬 😂 Read now in ACS Sensors: pubs.acs.org/ascefj/artic...

A Rationally Designed Split Lettuce Aptamer Based on Large-Scale Mutational Analysis

AbstractSplit-aptamer biosensors offer exceptionally low background by assembling only in the presence of a target analyte; however, their performance is f

pubs.acs.org

Admirable Women@admirablewomen.bsky.social · 4mo ago

Chemist & X-ray crystallographer Rosalind Franklin's meticulous research was instrumental in uncovering DNA's molecular structure. Most famous for her role in the DNA double helix discovery, her work also revolutionized our understanding of viruses & coal. Died #OTD in 1958, age 37. #WomenInSTEM

This black-and-white studio portrait photograph captures Rosalind Elsie Franklin, the brilliant British chemist and X-ray crystallographer whose meticulous research produced Photograph 51—the iconic X-ray diffraction image that revealed DNA’s double-helix structure and proved pivotal to the 1953 Watson-Crick model of the molecule. Shown in a close-up, three-quarter view from the shoulders up, Franklin appears in her late twenties or early thirties, her dark, wavy hair neatly styled and swept back from her face. She wears a simple, dark collared blouse or shirt with a crisp, professional appearance that reflects the understated elegance typical of mid-20th-century scientific women. Her expression is calm and intensely focused: direct gaze slightly off-camera to the viewer’s left, lips gently closed in a subtle, knowing half-smile, conveying quiet confidence, intellectual depth, and quiet determination. The plain, softly lit studio background with its neutral gradient emphasizes her face and upper torso, creating an intimate, timeless composition that places her poised presence at the absolute center.
Edward Pimentel@edwardpimentel.bsky.social · 4mo ago

New Martell Group paper alert! www.sciencedirect.com/science/arti... Cool work by Sifei Fang evolving APEX2 for proximity labeling probes with higher redox potentials! Amazing to see this project published.

Directed evolution of APOX for proximity labeling using phenols with high redox potentials

Proximity labeling (PL) can identify endogenous proteins in specific subcellular regions. APEX2 (enhanced ascorbate peroxidase 2) enables PL with high…

sciencedirect.com

Jeremy Baskin@jeremybaskin.bsky.social · 6mo ago

And save >80% on the cost by pooling 6 or more plasmids into a single sample using our free SAVEMONEY algorithm! elifesciences.org/articles/88794 colab.research.google.com/github/Masaa...

Barcode-free multiplex plasmid sequencing using Bayesian analysis and nanopore sequencing

SAVEMONEY is a computational tool that guides users to mix plasmids prior to nanopore sequencing, reducing the effective cost of whole-plasmid sequencing to below that of Sanger sequencing.

elifesciences.org

The bumbling biochemist (Bri Bibel)@bumblingbiochemist.bsky.social · 6mo ago

Whole plasmid sequencing (in my opinion) soooo beats Sanger for checking your molecular cloning (and do be sure to check your plasmids!!!!). youtu.be/RJmBxwEoFHw

Edward Pimentel@edwardpimentel.bsky.social · 7mo ago

Amazing work from the @aliceyting.bsky.social lab! Especially cool to see the functional effect of the conformational biasing on enzyme activity. www.science.org/doi/10.1126/...

Computational design of conformation-biasing mutations to alter protein functions

Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...

science.org

Jake Yeston@jakeyeston.bsky.social · 11mo ago

In @science.org this week @zachwickens.bsky.social and collaborators find a way to do Z-selective elimination using thianthrenium chemistry in a versatile route to Z olefins. chemsky 🧪 www.science.org/doi/10.1126/...

Stereo-reversed E2 unlocks Z-selective C–H functionalization

The stereoselective functionalization of C–H bonds represents a central challenge in modern organic synthesis. Despite decades of innovation in C–H activation chemistry, methods for Z-selective functi...

science.org

Chris Chang@christhechang.bsky.social · 11mo ago

Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...

An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis

Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...

pubs.acs.org

Edward Pimentel@edwardpimentel.bsky.social · 11mo ago

New preprint from the Soh lab! Nice work by my labmate Haji - new highly specific steroid aptamers identified using our modified sequencer platform! These don't have the 3wj structure and promiscuity of previous aptamers - I've used it myself! #chemsky www.biorxiv.org/content/10.1...

Discovery of high-specificity DNA aptamers for progesterone using a high-throughput array platform

Aptamer-based biosensors offer several advantages for detecting small molecules, including chemical stability and compatibility with diverse sensing formats. However, developing highly specific DNA ap...

biorxiv.org