📢 We are hiring a bioinformatician! 📍 @gustaveroussy.fr - U981 ⏳ 18 months contract 📩 hire.u981.hemonc@gmail.com Thanks for reposting #Recruitment #Genomics #Bioinformatics 👇
Effie Apostolou lab
@efapostolou29.bsky.social
Interested in 3D chromatin, cell fate decisions and gene regulation
Our study with @melnicklab on the discovery of a transient and tightly-regulated, plastic state of mature B cells during physiological immune response and potential links to aggressive lymphomas now out at NCB.👇Detailed threat by the amazing lead author @lscourzic.bsky.social!. .
T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response - Nature Cell Biology
Scourzic et al. show that germinal centre B cells display an enhanced ability to reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher plasticity ...
nature.com
Laurianne Scourzic@lscourzic.bsky.social · 7mo ago🚨 Our latest collaborative study with @efapostolou29.bsky.social & @LabMelnick regarding GC B cells’ transient epigenetic plasticity during the immune response is now out in @natcellbio.nature.com: https://www.nature.com/articles/s41556-025-01833-4. 🧵👇
Massive effort from the 4D Nucleome consortium and excellent resource for the community! Don’t miss it!
Job Dekker@jobdekker.bsky.social · 8mo agoA major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...
Our study with @stadtfeldlab.bsky.social on the dual mechanism by which EHMT2 is repressing totipotency-associated vs lineage-specific loci is now out @emboreports.org. See thread by @cmuyehara.bsky.social who led the study with K Chatterjee. Full article here link.springer.com/article/10.1...
Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 via LINE1 regulatory elements - EMBO Reports
Mouse embryonic stem cells (mESCs), in addition to differentiating into the three germ layers, can reverse typical developmental trajectories, as exemplified by their ability to de-differentiate into ...
link.springer.com
Chris Uyehara@cmuyehara.bsky.social · 2y agoKaushiki and I are excited to share our preprint about fate restriction in pluripotent cells! We show that EHMT2 counteracts the reactivation of clusters of totipotency genes by nucleating heterochromatin domains at LINE-1 repeats. 1/n @efapostolou29.bsky.social and Stadtfeld Labs #DevBio 🧬🖥️
Don't miss the chance to attend the annual virtual meeting on the advances in Nuclear Topology and 3D chromatin Architecture in Cancer organized by @janeskok @iannisaifantis1 @artsinyc and Melnick. The registration is FREE (see barcode) and the speaker lineup SPECTACULAR.
Don't forget to register for the upcoming Keystone Symposium Epigenetics & Gene Regulation in Health and Disease (Geveva, March 03-06). Join us for fun discussions on chromatin mechanisms and therapeutic innovation! keysym.us/KSEpigenetic...
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
keysym.us
👇👇👇
Dafne Campigli Di Giammartino@dafnecdg.bsky.social · 10mo ago🚨For chromatin, epigenetics and non-coding RNA lovers: only two more weeks left to apply! Check out our lab page and if interested don't hesitate to apply 3d-chrom.iit.it Research Technician app.ncoreplat.com/jobposition/... Senior Researcher-Technologist app.ncoreplat.com/jobposition/...
Honored and excited to be among the speakers in the upcoming #KSEpigenetics26 symposium! Thank you @kjarmache.bsky.social and @ckadoch.bsky.social for the invitation. Follow the link to register 👇👇👇
Karim-Jean Armache@kjarmache.bsky.social · 11mo agoOn behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...
Fraud, using A.I., impersonating medical professionals Front page NY Times www.nytimes.com/2025/09/05/t...
Honored to be part of the "Reprogramming Stars" interview series by @cellreprolab.bsky.social @CellularReprogramming. Humbling title but very fun discussion about past and ongoing research, future directions, advice to new trainees and more. Check it out! www.liebertpub.com/doi/10.1177/...
Reprogramming Stars #23: Charting Cell Fate Crossroads from the Interplay Between Epigenetics, Transcription, and 3D Chromatin Architecture—An Interview with Dr. Effie Apostolou | Cellular Reprogrammi...
Cellular Reprogramming
liebertpub.com
Another Exciting Fusion conference on 3D genome organization is coming up! #SGO25! Deadline for registration on September 1st! Hope to see many of you there!
Fusion Conferences@fusionconf.bsky.social · 12mo ago@efapostolou29.bsky.social we are looking forward to your presentation at the #SGO25 ! Please share this with your followers to let them know the poster and registration deadline is fast approaching - Monday 01 September! Register now ➡️https://bit.ly/4lhu1YX
NEW The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year Chokes off billions in research funding Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social
Trump Administration Puts New Chokehold on Billions in Health-Research Funding
The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.
wsj.com
The proposed budget slashes NIH by ~40%, devastating medical research, clinical trials, treatment breakthroughs—life-saving work. Thousands of lives at risk for tax cuts for the rich? NO THANKS. Tell your senators to oppose the cuts HERE: zurl.co/qiKdX zurl.co/RCR0y #CutsCostLives
Will the Senate Save NIH?
Rescuing biomedical research is every bit as important as saving Medicaid.
zurl.co
Check out this new preprint with @distefanolab.bsky.social lab! The manuscript focuses on RNA processing in the form of sequestration into P-bodies in the context of development.
Bruno Di Stefano@distefanolab.bsky.social · last yr.New preprint from the lab! With @brumbaugh-lab.bsky.social , we show that P-bodies sequester developmentally relevant RNAs to influence cell fate. miRNAs direct this conserved regulatory process, and manipulating it enhances totipotency and germ cell programming. www.biorxiv.org/content/10.1...
I am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...
training.nih.gov
A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.
The Groth lab@grothlab.bsky.social · last yr.🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
That’s huge!!! Congratulations Bing and welcome to NYC!!!
The first cancer-related story from our group @WeillCornell is now published in @MolecularCell. We investigate the role of hyperconnected 3D regulatory hubs in controlling oncogenic programs and properties in glioblastoma and also across 16 cancer types. www.cell.com/molecular-ce...
Three-dimensional regulatory hubs support oncogenic programs in glioblastoma
Here, Breves et al. profile the 3D enhancer-promoter connectomes of patient-derived glioblastoma stem cells (GSCs), identify hyperconnected 3D regulatory “hubs” relevant for GBM biology, examine the i...
cell.com
Postdoc position #1 is live! Please apply / spread the word! lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
Applications are invited for a 3-year post-doctoral research position at the MRC London Institute of Medical Sciences (LMS) at Imperial College London (http://lms.mrc.ac.uk/).
lms.mrc.ac.uk
It’s crazy how receiving an automated -previously routine- email that my grant application is scheduled for review this summer brought smile to my face! It can still be trashed but at least it would be after peer-review!!! #PIlife #GirlsJustWanttoHaveFUNding #StandforNIH
USA has been traditionally on the receiving end of braindrain thanks to its world class research and a culture of inclusivity…! Let’s see how that will play out…
Maria Polychronidou@mpolychronidou.bsky.social · last yr."Universities around the world have reported seeing an uptick in applications from U.S.-based researchers, who face an increasingly uncertain climate under President Donald Trump’s administration." ➡️ www.science.org/content/arti...
A nonsensical threat to: One of the most important advances in biotechnology of our time, already being used to successfully treat refractory cancers, enable genome editing, develop vaccines for infectious diseases for which there are none, treat autoimmune diseases, and more.
Alex Wayne@aawayne.bsky.social · last yr.Exclusive: NIH officials have advised scientists to remove reference to mRNA vaccines from their grant applications, in expectation the Trump administration intends to abandon most research in the field. By @arthurallen202.bsky.social kffhealthnews.org/news/article...
Our work on the regulation is out www.cell.com/stem-cell-re...! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine. #pluripotency #epigenetics #stemcells
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells
Pluripotent stem cells are susceptible to acquiring detrimental epigenetic abnormalities, posing a hurdle to their safe use in biomedical applications. Using pluripotent cells with defined genetic bac...
cell.com
Beautiful work by @stadtfeldlab.bsky.social and @tvierbuchen.bsky.social labs establishing the role of genetic variation in the epigenetic and imprinting stability of mouse iPS! Congrats!!!
Tommy Vierbuchen@tvierbuchen.bsky.social · last yr.Our collaborative project with Matthias Stadtfeld and Jason Mezey labs has now been published. We examined how genetic variation impacts regulation of DNA methylation at the control regions of imprinted genes in naive pluripotent stem cells. www.cell.com/stem-cell-re...
NIH is the best investment there is. www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
forbes.com
I received one of the 232 NIH grant "terminations" sent to scientists at Columbia last night. My research focuses on improving maternal and child health in the US. Also affected: ongoing clinical trials, research training programs, and research centers that aim to improve the health of Americans.
Hundreds of research grants at Columbia canceled following Trump edict, administrator says
The National Institutes of Health is terminating 232 grants for scientific research at Columbia University Irving Medical Center, according to an email an administrator sent to faculty.
gothamist.com
Devastating and outrageous!!! Where are we heading to???
Jeremy Berg@jeremymberg.bsky.social · last yr.I have confirmation from several sources now that all T32s, many F30s and F31s, and most or all Center awards (P30, P50) have been terminated at Columbia. This is quite damaging to research and to individuals. This is pure terrorism and cannot be legal. But litigation will take time...
It’s the first time in ten years that my money tree in my office is shedding a lot and looking sad… Should I stop reading the news in from of it😩? Is it an omen…? But seriously, any diagnosis or advice from plant experts out there? I really love it…
