www.theguardian.com/commentisfre...

Britain’s cars and SUVs are growing bigger – but there is a way to stop this deadly ‘carspreading’ | Christian Wolmar

Larger vehicles crowd our roads and are far more dangerous to pedestrians. Let’s curb them before they do even more damage, says says transport commentator Christian Wolmar

theguardian.com

It is out 😍 check it out!! Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning. @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social www.cell.com/cell/fulltex...

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

cell.com

🤯 Third ERC Advanced Grant @erc.europa.eu for @maxplanck.de Director Thomas Boehm (MPI-IE & @mpi-bio-fml.bsky.social)! He receives 2.5 million euros to study “Evolutionary plasticity of vertebrate immune systems” – the 🐟 anglerfishes and their bizarre matin behavior ❤️ are back! Congratulations 🥳

Thomas Boehm receives third ERC Grant for groundbreaking study on anglerfish immunity

Thomas Boehm has been awarded his third ERC Advanced Grant to investigate the unique immune system of deep-sea anglerfish and their immune tolerance mechanisms.

ie-freiburg.mpg.de

As Editor of @dev-journal.bsky.social I get asked "What are you doing about your impact factor?" In our new editorial we say: Ask not what Dev can do for the impact factor. Ask what you can do for Dev's IF The IF is about how we all cite, review & assess each other's work doi.org/10.1242/dev....

The elephant in the room: impact factor

Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...

doi.org

Thrilled to share that our paper is now published Developmental Cell! 🧬🎉 Spearheaded by Xian Zhang and Wilfred Wong, we built a human stem cell-based organoid system to model PDAC initiation. A huge team effort with our collaborators Rohit Chandwani and Christina Leslie. tinyurl.com/5ezyh3fa

Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation

Zhang et al. develop hPSC-derived pancreatic progenitor organoids that model PDAC initiation and progression. The model reveals that CDKN2A loss is uniquely required for human pancreatic transformatio...

cell.com

If you have experience in biochemistry/cryo-EM, are interested in DNA replication, and would like to do a postdoc in New York - our lab has positions available! Just DM or email me with your CV.

Postdoc position available now in the Smith Group lsi.exeter.ac.uk/groups/smith... to test the hypothesis that differentiation biases between human pluripotent stem cell lines may be eliminated by reversion to the naïve state. careers.exeter.ac.uk/vacancies/79...

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

cell.com

Is this the future of peer review? New from @biologyopen.bsky.social: expanded Fast & Fair trial paying reviewers £220 per paper The result: rapid peer review with no drop in quality or change in acceptance rate Paying referees makes peer review faster & fairer www.biorxiv.org/content/10.6...

The Frenster Lab is here! 🍾 I am so excited to start my #EmmyNoether funded group at @uni-freiburg.de this summer. Our group studies #CellCompetition dynamics during embryonic development using #gastruloids from multiple species. Thanks to the @dfg.de for creating this opportunity! FrensterLab.com

Frenster Lab | Cell Competition Dynamics

We study Cell Competition during Embryonic Development using 3D Gastruloids at the University of Freiburg. We view cells as interactive societies in development and cancer. Research, stem cells, Gastr...

frensterlab.com

Our latest work from The KottonLab, just out now, focused on lung endothelium: "A chimeric human-mouse lung vascular model using induced pluripotent stem cells reveals insights into the pathogenesis of BMPR2-related pulmonary hypertension": www.biorxiv.org/content/10.6...

My lab and the group of @efapostolou29.bsky.social are looking for a new lab manager/research tech. We are driven by basic questions of cell identity, epigenetics, and 3D genome regulation. If you believe you fit the bill or know somebody who does: jobs.weill.cornell.edu/job-invite/9...

Beautiful study by @m-stower.bsky.social, Shankar Srinivas and colleagues into how coordinated cell movements shape axial identity in the very early mouse embryo. www.biorxiv.org/content/10.6... #embryogenesis #development #patterning

I am excited to announce that I have received a Travel & Merit Award for the #ISSCR2026 Annual Meeting about my work modeling mouse cranial and cardiac neural crest development in vitro. Many thanks to my mentor @tvierbuchen.bsky.social for his guidance and support throughout this project @ISSCR.org

I'm attending the ISSCR 2026 Annual Meeting, join me

Register now

invt.io

1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. www.cell.com/molecular-ce...

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains

Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize...

cell.com

Particularly excited to announce "In Formation" 👉Vernissage 17h00 Munich *5th of July* @Muffatwerk 1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin replifate.eu/event/in-for... 😇STAY TUNED 4more info

Events for February 2026

We are thrilled to announce In Formation, the first exhibition featuring work from four artist-in-residence projects that bring art into the heart of scientific stem cell and epigenetics research. ...

replifate.eu

Final version of our paper now published. elifesciences.org/articles/109... Take homes: CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n

The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.

elifesciences.org

An insightful account of the review process at one of the most pre-eminent and influential journals in developmental and stem cell biology, by @jamesbriscoe.bsky.social and fellow @dev-journal.bsky.social editors. #Development #how-to-review #how-to-publish journals.biologists.com/dev/article/...

The hard truth about how hard it is to publish in Development

Every researcher knows the anticipation and trepidation that come with submitting a paper to a journal. Years of effort have been distilled into a few thousand words and a handful of figures containin...

journals.biologists.com

Very interesting pre-print from Chris Baker's lab at JAX on the mechanistic link between trans-acting genetic variants and heterochromatin formation in mice. #heterochromatin #epigenetics #variants www.biorxiv.org/content/10.6...

Trans-regulation of heterochromatin underlies genetic variation in 3D genome contacts

Genetic variation drives phenotypic diversity and disease susceptibility. Trans -acting genetic variation coordinates genome-wide chromatin changes, yet the molecular mechanisms underlying this regula...

biorxiv.org

Very excited to announce that our collaborative study with @efapostolou29.bsky.social on the transcriptional mechanisms distinguishing totipotent and pluripotent cells has been published (link.springer.com/article/10.1...). #totipotency #ZGA #stemcells #epigenetics #chromatin

Interesting and elegant study by Simon Braun's group in Geneva into redundant and unique functions of specific SWI/SNF components during mouse neurodevelopment. www.biorxiv.org/content/10.6... #degrons #neurodevelopment #chromatin

Very happy to see this published! 🎉🎉🎉 Amazing collaboration with Max Yun and her team @maxyunlab.bsky.social @crtd-tud.bsky.social on Axolotl Thymus regeneration. Thanks also to @claireolingy.bsky.social for coverage, and grateful for December cover #scienceimmunology www.science.org/doi/10.1126/...

Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl

The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.

science.org

Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions: Mentoring Profile raising Leadership training Network building Spread the word... www.biologists.com/grants/devel...

Development's Pathway to Independence Programme

Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

biologists.com

new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4 rdcu.be/eOc0q

Human DICER1 hotspot mutation induces both loss and gain of miRNA function

Nature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are...

rdcu.be

📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...

Don't miss the chance to attend the annual virtual meeting on the advances in Nuclear Topology and 3D chromatin Architecture in Cancer organized by @janeskok @iannisaifantis1 @artsinyc and Melnick. The registration is FREE (see barcode) and the speaker lineup SPECTACULAR.

Very insightful study by @distefanolab.bsky.social and @brumbaugh-lab.bsky.social labs, revealing RNA sequestration as a mechanism to restrict and direct cellular plasticity.

Bruno Di Stefano@distefanolab.bsky.social · 9mo ago

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

For over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease. But the mouse reference genomes still have missing pieces. The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains. 🧬💻

Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 10mo ago

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1

Happy to see some of the work I’ve done during my PhD officially published! Check it out!

Chris Parker@chrisgparker.bsky.social · 10mo ago

Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins. This was a big team effort led by @inesforrest.bsky.social and in collaboration with AbbVie.