Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling @ellenfoxman.bsky.social @yalepress.bsky.social www.cell.com/cell-press-b... @cellpressblue.bsky.social
Ellen Foxman
@ellenfoxman.bsky.social
Associate Professor, Immunologist, Physician-Scientist. Studying human immunology, innate immunity, host-virus interactions for better diagnosis, treatment, prevention. Opinions are my own.
Mechanistic insights into the impact of prenatal viral infections on maternal and offspring immunity www.nature.com/articles/s44...
Mechanistic insights into the impact of prenatal viral infections on maternal and offspring immunity - npj Viruses
npj Viruses - Mechanistic insights into the impact of prenatal viral infections on maternal and offspring immunity
nature.com
#Interferons protect against #ViralInfection, but can hinder tissue repair - how? @ellenfoxman.bsky.social &co show that high IFN levels suppress #BronchialCell migration & proliferation during tissue repair via JAK-driven LATS1 activation, independent of STAT1 @plosbiology.org 🧪 plos.io/4k1pyKA
Thank you to Bob McDonald for hosting me on @CBCRadioCanada to discuss our work @yaleschoolofmed.bsky.social on what leads to variation in common cold virus infections and how we tackled this using nasal organoids. Listen here: www.cbc.ca/listen/live-...
© CBC/Radio-Canada 2026. All rights reserved.
cbc.ca
Excited to see this beautiful image of nasal #organoids featured as biomedical Image of the day by @cellpress.bsky.social 🙏🙏🙏 See full paper @cellpressblue.bsky.social #respiratory #lungs #EpithelialMechanics #IdSky #MedSky #ImmunoSky
Biomedical Picture of the Day BPoD@bpodaily.bsky.social · 6mo agoResponse to rhinovirus depends on levels of interferon production & viral load – differences revealed using a nasal organoid 📷 Julien Amat & Bao Wang, relating to B.Wang et al article @yaleschoolofmed.bsky.social in @cellpressblue.bsky.social ➡️ bpod.org.uk/archive/2026... with @rooph.bsky.social
#Epithelialmechanics fans...interferons protect against viruses but also impair recovery post-infection. In new work @plosbiology.org we show that interferons block epithelial repair by co-opting the Hippo pathway #innateimmunity #lungs #respiratory journals.plos.org/plosbiology/...
Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells
Interferons (IFNs) initiate antiviral defence when infected cells sense a virus protecting against infection via JAK/STAT signaling, but can hinder recovery by impairing tissue repair by an unknown me...
journals.plos.org
Frequent presymptomatic household transmission of influenza A but not influenza B virus www.nature.com/articles/s44...
Frequent presymptomatic household transmission of influenza A but not influenza B virus - Nature Health
Based on two waves of data collection from 748 households in Hong Kong, this analysis sheds light on the number of transmission events that occurred before manifestation of symptoms in influenza A and...
nature.com
#Interferons protect against #ViralInfection, but can hinder tissue repair - how? @ellenfoxman.bsky.social &co show that high IFN levels suppress #BronchialCell migration & proliferation during tissue repair via JAK-driven LATS1 activation, independent of STAT1 @plosbiology.org 🧪 plos.io/4k1pyKA
#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo 🦛 pathway! journals.plos.org/plosbiology/... 👇👇👇
Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells
Interferons (IFNs) initiate antiviral defence when infected cells sense a virus protecting against infection via JAK/STAT signaling, but can hinder recovery by impairing tissue repair by an unknown me...
journals.plos.org
PLOS Biology@plosbiology.org · 6mo ago#Interferons protect against #ViralInfection, but can hinder tissue repair - how? @ellenfoxman.bsky.social &co show that high IFN levels suppress #BronchialCell migration & proliferation during tissue repair via JAK-driven LATS1 activation, independent of STAT1 @plosbiology.org 🧪 plos.io/4k1pyKA
#Interferons protect against #ViralInfection, but can hinder tissue repair - how? @ellenfoxman.bsky.social &co show that high IFN levels suppress #BronchialCell migration & proliferation during tissue repair via JAK-driven LATS1 activation, independent of STAT1 @plosbiology.org 🧪 plos.io/4k1pyKA
Interested in the common cold virus? Check out this clip from the Naked Scientist podcast about our recent study in which we observed thousands of nasal cells interact to cause (or stop) symptoms of common cold infections. #MedSky #IDsky #lungs www.thenakedscientists.com/articles/int...
Nose-in-a-dish: Scientists recreate common cold in culture
Rhinoviruses really nose how to change cells...
thenakedscientists.com
Fantastic work @ellenfoxman.bsky.social &co! If you block the #InterferonPower, Rhinovirus activates NFkB & NLRP1 #inflammasome leading to IL1b secretion & excessive mucus production!
Ellen Foxman@ellenfoxman.bsky.social · 7mo agoRhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...
Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...
Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling
Rhinoviruses are the most frequent cause of common colds and also a major cause of respiratory distress in high-risk groups. Using single-cell sequencing of rhinovirus-infected nasal epithelial organo...
cell.com
Cells in our nasal passages can detect common cold viruses and mount a defense before we catch it. spkl.io/63321Ao5fV @ellenfoxman.bsky.social & colleagues @cellpressblue.bsky.social
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this. www.science.org/doi/... 1/9
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that naked mole-rat cyclic guanosine monophosphate–adenosine ...
science.org
Happy to share this review just out in Current Opinion in Immunology on innate immunity in the respiratory tract - also check out the other reviews in this collection on Intrinsic Immunity edited by John MacMicking #ImmunoSky #IDSky #pulmsky #MedSky www.sciencedirect.com/science/arti...
Layers of defense: protection from respiratory viruses by epithelial-intrinsic immunity
A central challenge in defending mucosal barriers is protecting against pathogens while also limiting excessive inflammation. Respiratory viruses are …
sciencedirect.com
#COVID19 revealed the urgent need for better ways to screen for & rule out respiratory virus infection. We present a nasal biomarker screening strategy to prevent & manage outbreaks @eBiomedicine.bsky.social #IDSky #MedSky #lungs @yaleschoolofmed.bsky.social www.thelancet.com/journals/ebi...
Nasal biomarker testing to rule out viral respiratory infection and triage samples: a test performance study
These results demonstrate the utility of a nasopharyngeal biomarker to rule out respiratory infection, with potential applications in outbreak management and/or routine screening in high-risk settings...
thelancet.com
ASSIGNMENT: COMMENT ON SCHEDULE F 1 week left to comment about Schedule F, potentially making NIH institute and center director essentially political appointees. www.regulations.gov/commenton/OP... 1/n
Regulations.gov
regulations.gov
Nice coverage of our H5 mRNA work by Jon LaPook tonight on @cbseveningnews.bsky.social www.cbsnews.com/video/the-sc...
The scientists aiming to stay ahead of bird flu on dairy farms and prevent a human pandemic
So far, the only people to come down with bird flu got it from animals. Dr. Jon LaPook reports on how research is underway to keep bird flu from mutating into a form that could spread from person to p...
cbsnews.com
Are you a scientist and not sure what to do to help with all the awfulness all around us? Inspired by Vietnam era activism, @standupforscience.bsky.social is hosting a series of "teach ins," in which scientists share a bit about their area of expertise and why it's important with the public. 🧪🦑🌎
Check out this news story that @nature.com wrote describing our recent preprint where we tested our H5 mRNA vaccine in calves. The data look good and we are currently testing the vaccine in lactating cattle...more to come!
Nature@nature.com · last yr.As bird flu sweeps across US poultry and cattle farms, researchers are racing to find ways to contain the outbreaks before they ignite a human pandemic. Now, a team of scientists has developed a fresh approach: the first mRNA bird-flu vaccine for cattle. https://go.nature.com/4kbOvTe
Spectacular view of 100,000 people attending the #HandsOff march in NYC
Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
elifesciences.org
Top F.D.A. Vaccine Official Resigns, Citing Kennedy’s ‘Misinformation and Lies’ Gift link: nyti.ms/3DTuvVr
Top FDA Vaccine Official Resigns, Citing Kennedy’s ‘Misinformation and Lies’ (Gift Article)
Dr. Peter Marks, a veteran of the agency, wrote that undermining confidence in vaccines is irresponsible and a danger to public health.
nyti.ms
We are seeking to hire a lab tech, this is an HHMI funded position, please share the job posting: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Lab Administration Research Technician- Bertozzi Lab
Primary Work Address: Beckman Center, Stanford, CA, 94305-5323 Current HHMI Employees, click here to apply via your Workday account. We are currently looking for a highly motivated Lab Administration ...
hhmi.wd1.myworkdayjobs.com