The week of publications continues for the lab with a @currentbiology.bsky.social piece on ninj1 by @elliottbernard.bsky.social and @ehartenian.bsky.social check it out to have all your pressing ninj1 questions answered :) www.cell.com/current-biol...

Our latest work from @brozlab.bsky.social and led by @alexandraboegli.bsky.social is out now in @embojournal.org. Check out our findings on how the intestinal #inflammasome NLRP6 senses lysosomal damage to trigger pyroptotic cell death.

The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage | The EMBO Journal

imageimageThe innate immune sensor NLRP6 is known to control host defense against bacteria and viruses in the gastrointestinal tract by a poorly-understood mechanism. This study shows that NLRP6 forms...

embopress.org

It's always a pleasure to spend the day out with the lab. Today was all about sharing our research and hearing about the other work going on in the department. I was able to share and get valuable feedback on our latest insights on NINJ1 in #celldeath and #inflammation.

Broz Lab@brozlab.bsky.social · 9mo ago

It’s DIB day! The annual conference for our department @dib-unil.bsky.social. Lovely day (and view!) at the Lausanne Olympic museum exchanging with our colleagues. Plus a stellar presentation on NINJ1 by our own @elliottbernard.bsky.social 🔬!

Registration opens soon for the second Pattern Recognition receptor symposium in Lausanne Switzerland in October 2025. Check out the link for the great list of speakers. wp.unil.ch/immunobiolog...

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland. Registrations open March 1 - Attendance limited to 150 participants. More info: wp.unil.ch/immunobiolog... #ImmunoSky

#Pathogens #Lysosomes #CellDeath what's not to like? Check out our latest work deciphering how the protein NLRP6 links all of these to protect your gut from infections like Listeria.

Broz Lab@brozlab.bsky.social · 2y ago

Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press! www.biorxiv.org/content/10.1...

New research revealed how NINJ1 is kept inactive in living cells. Head over to Nature News & Views to check out our thoughts on these cool findings. Free to read at rdcu.be/d2nqH

Broz Lab@brozlab.bsky.social · 2y ago

First real bluesky post 🥳 Did you know that NINJ1 exists as an autoinhibited dimer in the PM of cells? In a News & Views, @elliottbernard.bsky.social and Petr describe new results from Dixit & Deshpande, including a resting structure of NINJ1 with 3 helices! Check it out here: rdcu.be/d2nqH

If you're interested in knowing what I'm currently working on in the lab, we recently posted a preprint of our findings www.biorxiv.org/content/10.1... I study cell death and inflammation and am also interested in how cells defend themselves against infection.

Ninjurin-1 mediated plasma membrane rupture is a two-step process requiring cell swelling

Plasma membrane rupture (PMR) and the release of cytosolic content are hallmarks of necrotic cell death. The plasma membrane protein ninjurin-1 (NINJ1) actively promotes cell lysis by polymerizing int...

biorxiv.org