For those interested in studying cell-cell communication, check out our latest methodological work in AJHG where we discuss more powerful and practical techniques for this task. Project was joint effort with @yjingj.bsky.social and led by our incredible trainee Dr. Qile Dai (now at Lilly)

The American Journal of Human Genetics@ajhgnews.bsky.social · 2mo ago

🧬Online now! 📄Identifying condition-related cell-cell communication events using supervised tensor analysis 🧑‍🤝‍🧑 @epsteinstatgen.bsky.social @yjingj.bsky.social & Dai 🖥️ github.com/daiqile96/ST...

🧬Online now! 📄Identifying condition-related cell-cell communication events using supervised tensor analysis 🧑‍🤝‍🧑 @epsteinstatgen.bsky.social @yjingj.bsky.social & Dai 🖥️ github.com/daiqile96/ST...

Identifying condition-related cell-cell communication events using supervised tensor analysis

Cell-cell communication (CCC) events coordinate physiological functions in multicellular organisms and are important for exploring biological processes and disease mechanisms. We introduce STACCato, a...

cell.com

Happy to see this out w/ @epsteinstatgen.bsky.social and @davecutler.bsky.social (paper: doi.org/10.1093/bioi...)! We tackled the problem of identifying dysregulated pathways (i.e. differentially co-expressed) in gene expression studies. We show that differential co-expression arises ...

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

Excited to see our (w/ @chr1sw.bsky.social) work published in @natcomputsci.nature.com! We developed a new framework, surrogate functional false discovery rate (sffdr), that integrates summary statistics of related traits to improve power in GWASs. Paper: www.nature.com/articles/s43...

Exploiting pleiotropy to enhance variant discovery with functional false discovery rates - Nature Computational Science

This study introduces a cost-effective strategy called surrogate functional false discovery rates to increase power in genome-wide association studies by leveraging genetic correlations (or pleiotropy...

nature.com

RIP, Prince of Darkness. Arguably in the Top 5 of most influential artists of my lifetime

Dave Itzkoff@ditzkoff.bsky.social · last yr.

I truly thought this man was going to live forever, somehow. RIP, Ozzy, you were metal incarnate for me. news.sky.com/story/ozzy-o...

Our new AJHG paper is online. We develop a new TWAS tool that uses local-ancestry information to improve power of gene mapping in admixed samples. Lead author Taylor Head (now at MD Anderson) did a phenomenal job spearheading this work!

The American Journal of Human Genetics@ajhgnews.bsky.social · last yr.

🚨New method! 📄CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data 🧑‍🤝‍🧑 @epsteinstatgen.bsky.social @yjingj.bsky.social & co

Incredible GRC Genetics and Genomics conference line-up this year in Portland, Maine (www.grc.org/human-geneti...). With conference-maxxing sessions that run to 9:30pm! Submission deadline is June 8th, conference July 6-11th.

Multiple Postdoc Positions available in Epidemiology, Biostatistics, or Statistical Genetics (deadline April 15) Join an International team at the Pioneer Centre for SMARTbiomed, Aarhus, Denmark! #Postdoc #Epidemiology #StatisticalGenetics #Biostatistics 👉 international.au.dk/about/profil...

Postdocs in Epidemiology or Statistical Genetics at The Pioneer Centre for SMARTbiomed - Vacancy at Aarhus University

Vacancy at Department of Public Health - NCRR - National Centre for Register-based Research, Aarhus University

international.au.dk

Happy Chrismukkah to all the delightful half-half situations (like me)

Accurate.

For those working in pathway and co-expression analysis, check out Andy’s recent preprint describing a more powerful and flexible framework for such studies!

Andrew Bass@ajbass.bsky.social · 2y ago

Differential co-expression arises from shared unmodeled biological variation involving an observed risk factor and an unobserved (or latent) factor. We developed a method to detect such variation in a pathway for general gene expression studies!

We humbly thank the reviewers for their suggestions. We would like to resubmit this improved manuscript for your consideration. #AcademicSky #MedSky

I'm developing a pipeline to call CHIP mutations in UK Biobank using the DNA Nexus RAP that is fast/cheap/reproducible. Initial results are promising; calls looks reasonable and cost to do this across all of UKB is likely < 500$. Feel free to DM if of interest.

Finally a VP who’s had to design a syllabus!

Excited to share our method LIT; a kernel approach to map genetic variants with interaction effects on multiple phenotypes in biobanks. R package implementing the method available on CRAN. Kudos to Andy Bass for leading this work! genomemedicine.biomedcentral.com/articles/10....

Identifying latent genetic interactions in genome-wide association studies using multiple traits - Genome Medicine

The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propose a n...

genomemedicine.biomedcentral.com

CHARLIE BROWN: Can I kick it? LUCY: Yes, you can! CHARLIE BROWN: Can I *kick* it? LUCY: Yes, you can! CHARLIE BROWN: Can I _kick_ it. LUCY: Yes, you can! CHARLIE BROWN: {running toward ball} Well, I’m gone! LUCY: {pulling the ball away} Gone!

Please be sure to check you kid's candy this year. I just found another project I have no time for in a Reese's cup

Preprint is up now www.biorxiv.org/content/10.1...

Trying to be better with sharing work on here 😅 Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠

medRxivpreprint@medrxivpreprint.bsky.social · 3y ago

Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival https://www.medrxiv.org/content/10.1101/2023.10.15.23296448v1

👋 Hi genetics/statgen/gen-epi trainees! 🧬 🧪 If you are interested in reviewing please let me know! We (HGG Advances, eLife) are constantly in need of knowledgeable reviewers and would be more than happy to work with you. Please feel free to email me (or other editors) if you're interested!

Pep and jazz band member Latin Club member who also took Ancient Greek Listened to Rush 24/7. I checked all the boxes

KidzBoptotenlieder@theodramatist.com · 3y ago

I can’t imagine any Bsky early adopter was cool in high school, so what kind of loser were you?

bioRxiv goes big on Bluesky: accounts for all subject categories now available (Please Reskeet) connect.biorxiv.org/news/2023/09...

Introducing some cool work by @ajbass.bsky.social in my lab for detecting genetic variants with interactive effects on phenotypes of interest in biobanks leveraging pleiotropy. Hope you find it interesting!

Andrew Bass@ajbass.bsky.social · 3y ago

A preprint of my first post-doc paper w/ Shijia Bian, Aliza Wingo, Thomas Wingo, David Cutler and @epsteinstatgen.bsky.social is out! www.biorxiv.org/content/10.1...

Just curious; what is the longest wait time anyone has experienced for a desk rejection?

GWAS of antimullerian hormone (AMH) levels in the Finnish population. One of the hits is CHEK2 driven by a loss of function variant that is 4x enriched in Finland. Pujol-Gualdo et al. medRxiv www.medrxiv.org/content/10.1...

My latest cure for writer’s block

@danirabaiotti.bsky.social : could I please be added to the science feed? Thanks so much!

What cheat codes unlock the secret character