Spinoza Award for Chemical Biologist Hermen Overkleeft from Leiden University! We are extremely excited that Hermen Overkleeft from the Leiden Institute of Chemistry and our @led3hub.bsky.social was awarded the highly prestigious Spinoza Award. (1/5) www.universiteitleiden.nl/en/news/2026...

Spinoza Prize for chemical biologist Hermen Overkleeft

Professor of Bio-organic Chemistry Hermen Overkleeft develops innovative methods to study disease processes. This increases our understanding of the human body and enables the development of new medicines. Overkleeft has been awarded the Spinoza Prize: the most prestigious scientific award in the Ne…

universiteitleiden.nl

Amazing news that Hermen Overkleeft of @led3hub.bsky.social and @leidenscience.bsky.social was awarded the Spinoza Award! The Spinoza Award is the highest scientific Award of the Netherlands. www.nwo.nl/en/professor... #ChemBio #ChemSky #Glycotime #DrugDiscovery #Award

Professor Hermen Overkleeft | NWO

Hermen Overkleeft is known worldwide as one of the founders of chemical biology. This is the field that designs molecules to analyse biological processes. As a professor of bio-organic chemistry at th...

nwo.nl

We're excited to share Prof Andrew Roberts AM & Prof Suzanne Cory AC have received prestigious honours from the @ash.hematology.org 👏 The honours recognise their outstanding scientific contributions that continue to transform outcomes for patients worldwide. www.wehi.edu.au/news/prestig...

Thank you @endpts.com for sharing the story about Grace Science, so close to bringing gene therapy to patients with NGly1 disease, hoping for some regulatory flexibility. endpoints.news/grace-scienc...

A father built a gene therapy for his daughter. He says an FDA request is the bottleneck

Grace Science CEO Matt Wilsey says FDA demands could kill its gene therapy for the rare and fatal NGLY1 deficiency by September without new funding or a regulatory break.

endpoints.news

Congratulations to the teams at Palleon and Henlius, first patients dosed with B7H3-targeted sialidase immune therapy for ovarian cancer. Great partnership around glycan editing, an exciting new approach for immune modulation #glycotime www.businesswire.com/news/home/20...

How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇

Check out our latest paper on the ubiquitination of glycogen in cells and tissues! Congratulations to Marco Jochem (@marcojochem.bsky.social) and Simon Cobbold for leading this study and to collaborators @craigagoodman1.bsky.social, @pgregorevic.bsky.social, Kai Hofmann and Thomas Hermanns.

Marco Jochem@marcojochem.bsky.social · 4mo ago

Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...

Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...

Without immediate government support, 10 of Victoria's 14 medical research institutes will be forced to close within 5 years. This would be a devastating outcome for a sector which has contributed greatly to the health and economic prosperity of this country www.theaustralian.com.au/health/ten-v...

Another postdoc position for my lab is now open. This one is for a biochemist/cell biologist who really likes mitochondria and ubiquitin. If this is you, please apply here: www.seek.com.au/job/91277535

Biochemist/Cell Biologist Research Officer Job in Parkville, Melbourne VIC - SEEK

An excellent opportunity is available for a Research Officer / Senior Research Officer to join the Callegari Lab at WEHI.

seek.com.au

"We identified 13 genome-wide significant loci associated with SARS-CoV-2 infection. The strongest signal was a single nucleotide polymorphism in an intron of ST6GAL1 (...) connected to three other associated loci (harboring MUC1, MUC5AC and MUC16)" #glycotime 🧪 www.nature.com/articles/s41...

Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants - Nature Genetics

Genome-wide analyses identify 13 loci associated with susceptibility to infection with SARS-CoV-2 Omicron variants, including variation in ST6GAL1, previously associated with influenza susceptibility,...

nature.com

We integrated experimental and computational approaches to generate a systems-level view of a key post-translational modification, O-GlcNAc. In vivo studies across tissues reveal shared and tissue-specific functions. Congrats to Matt, John, Yao, and the whole team! #NOTISEme bit.ly/3ZgCOBM

Functional analysis of O-GlcNAcylation by networking of OGT interactors and substrates - Nature Chemical Biology

Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activiti...

doi.org

WEHI researchers have helped to engineer an antibody that can clear otherwise lethal multidrug‑resistant Acinetobacter baumannii infections in mice by homing in on the bacterial sugar pseudaminic acid. Brilliant findings, published in Nature Chemical Biology www.wehi.edu.au/news/sugar-m... 🧵1/2

🚨 Our new paper is out today in Nature Chemical Biology: “Pan-specific antibodies to uncover bacterial pseudaminylation” doi.org/10.1038/s415... This is the product of a collaboration between many teams, led by @nickescott.bsky.social, @payneresearch.bsky.social and myself. 1/6

Uncovering bacterial pseudaminylation with pan-specific antibody tools - Nature Chemical Biology

Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recogn...

doi.org

In a new Science study, researchers introduce DrugCLIP, a contrastive learning framework that virtually screens small molecules and protein pockets, analyzing protein-ligand interactions 10 million times faster than most standard molecular docking approaches. https://scim.ag/45FfSj2

Deep contrastive learning enables genome-wide virtual screening

Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugC...

scim.ag

GLYCO-BUILD, an entirely enzymatic approach for the production of N-glycans and N-glycopeptides. www.nature.com/articles/s41...

A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics | Analytical Chemistry pubs.acs.org/doi/10.1021/.... Making your data better viuable, no matter whether it is "boring" proteomics, or more exciting glycoproteomics, cross-linking mass spectrometry etc.

A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics

Accurate and comprehensive peptide spectrum annotation is a crucial step to interpreting mass spectrometry-based proteomics data. While peak assignment in peptide fragmentation spectra is central to a...

pubs.acs.org

🎉 Congratulations to our 2026 AGS EMCR Award winners! 🎉 🏅 Protein Metrics ECR Awardee - Dr Jonathan Du 🏅 SHIMADZU MCR Awardee - Prof Morten Andersen Both awardees are recognised for outstanding contributions to glycoscience 👉 ozglyco.org A huge thanks to our sponsors for supporting these awards 👏

The last chapter from my postdoc days is finally online! We solve structures of the ER membrane O-mannosyltransferase Pmt4 and uncover a functionally important cytosolic binding site for the Dol-P-Man substrate lipid - allosteric regulation or a long sought after Dol-P-Man flippase?? 🔄 rdcu.be/eUJfb

Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions

Nature Biotechnology@natbiotech.nature.com · 8mo ago

Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8

Excited to share a new publication from my PhD labs where we explore a method to improve antibody-mediated protection against herpes simplex virus infections: www.science.org/doi/10.1126/...

Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice

HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.

science.org

The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel... #ChemNobel #Chem #Chemistry #chemsky 🧪

The 2025 chemistry Nobel goes to MOFs

Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks

cen.acs.org

Dear Everyone, I've read the #NHMRC draft strategy and I have notes ... So I'm going to...🧵🤔🧵😱🧵😵‍💫🧵🙏🧵🧵🧵 This is a repost from X because you all need to know! #NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience @nhmrc.bsky.social

Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social chemrxiv.org/engage/chemr...

Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase

O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...

chemrxiv.org

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.09.24.678028 #proteindesign

Beautiful enzyme evolution work by Steve Withers and coworkers 👏 pubs.acs.org/doi/10.1021/...

Reshaping of a Glycoside Hydrolase Active Site through Expression-Compensated Droplet-Based Microfluidic Screening Provides Useful Tools for Glycomics

The glycosylation of proteins endows them with distinct biophysical properties and allows them to play fundamental roles in cellular communication. Much of our understanding of glycoproteins has deriv...

pubs.acs.org

Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works. 🔗 www.wehi.edu.au/news/eureka-...

The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!

Last but most certainly not least, The President’s Innovator Award 2025 goes to Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂