Albert Heck
@hecklab.bsky.social
Professor in Biomolecular Mass Spectrometry and Proteomics, Utrecht University, the Netherlands
Congratulations to LS1 grantees @hecklab.bsky.social and Annarita Miccio at @institutimagine.bsky.social , for being awarded ERC POC grants! :)
European Research Council (ERC)@erc.europa.eu · last mo.The round 1 results of the 2026 ERC Proof of Concept Grant call are out! 🎉 182 researchers receive a total of €27.3 million to explore the commercial and societal potential of their ERC-funded findings. Read more 👉 buff.ly/K8GXgbs #ERCPoC #FrontierResearch @scienceinnovation.ec.europa.eu
Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/
Nikolai Slavov@slavov-n.bsky.social · 2y agoWe report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. www.biorxiv.org/content/10.1...
Our article is out in Nature Communications! We identify ATP synthase as a new link between OXPHOS and the TCA cycle, and these interactions are remodelled upon mitochondrial dysfunction. Co-authored with Jelena Misic, @tkadava.bsky.social, @nils-goranlarsson.bsky.social, @hecklab.bsky.social
It was great to have you @asms.org #ASMS2026 in San Diego! Your Plenary Lecture was a great way to end our conference. I hope you didn't mind talking about Science Integrity continuously during the USS Midway tour afterwards with our members. Thanks for discussing this important topic in science.
Elisabeth Bik@elisabethbik.bsky.social · 2mo agoTraveling today to San Diego, to give the closing plenary at the @asms.org #ASMS2026 #MassSpectrometry meeting. I am not aware of a lot of MS fraud, and would have a hard time finding it myself, but hopefully we can learn from each other. This might be my biggest audience ever (7K participants)!
Traveling today to San Diego, to give the closing plenary at the @asms.org #ASMS2026 #MassSpectrometry meeting. I am not aware of a lot of MS fraud, and would have a hard time finding it myself, but hopefully we can learn from each other. This might be my biggest audience ever (7K participants)!
ASMS@asms.org · 2mo agoSafe travels, #TeamMassSpec! We’ll see you this week in San Diego. #ASMS2026
#ASMS2026 Huge congratulations to Albert @hecklab.bsky.social for winning the ASMS John Fenn award for a Distinguished contribution in Mass spectrometry! well-deserved! A truly inspiring talk👍👏✨
The next episode in our quest at @utrechtuniversity.bsky.social to answer "what do we know about your antibodies?" Structural promiscuity in the human circulatory IgA1 clonal repertoire | PNAS www.pnas.org/doi/10.1073/.... Funded by @erc.europa.eu. Congrats to Amber Rolland
Structural promiscuity in the human circulatory IgA1 clonal repertoire | PNAS
Immunoglobulin A (IgA) is the most abundant antibody in humans, with high concentrations in both mucosae/secretions and circulation. While mucosal ...
pnas.org
Congratulations to Albert J.R. Heck, recipient of the 2026 #ASMS John B. Fenn Award for Distinguished Contribution! A leader in the field, his work continues to shape the future of #massspectrometry. We’re excited to celebrate his achievements at #ASMS2026 in San Diego.
A nice Polish - Dutch collaboration with the @iimcb.bsky.social. Congratulations to Mayra Borrero, Vanessa Linke and @tkadava.bsky.social. A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity | Science Advances www.science.org/doi/10.1126/...
A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity
Human TOM complex was revealed as a dynamic hub, with FKBP8 as a human-specific interactor shaping biogenesis.
science.org
We did a plasma proteomics study on dengue disease severity in children with Tineke Cantaert and identified early markers of endothelial and inflammatory activation. Great work by @tshamorkina.bsky.social and Sofia! Thanks to all co-authors @hecklab.bsky.social. www.medrxiv.org/content/10.6...
Host cell remodeling via cyclin dependent kinases drives Ebola virus replication and transcription. www.biorxiv.org/content/10.6... Check out our latest preprint. Great work by @tshamorkina.bsky.social. Thanks to co-authors Danni Snikkers and @hecklab.bsky.social
A nature-inspired ion trap for parallel manipulation of ions on a massive scale | Science Advances www.science.org/doi/10.1126/.... Very nice work by Brian Chait and Andrew Krutchinsky from @rockefeller.edu inspired by parallel sequencing in genomics and other technologies. Congratulations
A nature-inspired ion trap for parallel manipulation of ions on a massive scale
A nature-inspired ion trap enabling massively parallel mass spectrometry.
science.org
Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry: Cell Systems www.cell.com/cell-systems.... How great would it be to sequence proteins without a gene-template! We might be approaching this soon.
Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry
Highly efficient hyperthermal acidic proteases combined with hybrid-fragmentation schemes provide five times more unique peptide reads than trypsin or chymotrypsin, greatly boosting confidence in de n...
cell.com
These HTA proteases from archaea work great for mass spec-based antibody sequencing. Paper out now in final form at Cell Systems. Congrats to @tshamorkina.bsky.social @tkadava.bsky.social @lperezpaneda.bsky.social and @hecklab.bsky.social www.sciencedirect.com/science/arti...
I wonder... 🤔🤔🧪 #chemsky a) what program did the authors use to make the original (left) figure in the paper? Wild guess, ChatGPT b) how such high school science level of disgrace pass peer review in @nature.com? Note this was Fig.4.a NOT in SI www.nature.com/articles/s41...
Got an Orbitrap-based mass spec that couldn’t do STORI/direct mass technology before (any aside from the UHMR and Tribrid Ascend)? This is a cool open-source implementation that even works on an Orbitrap Elite! #teammassspec
Tim Cleland@paleoproteomicist.bsky.social · 7mo agoIntroducing Theropod. A set of python and R tools that I’ve put together to do STORI analysis with an external digital oscilloscope. pubs.acs.org/doi/10.1021/...
A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics | Analytical Chemistry pubs.acs.org/doi/10.1021/.... Making your data better viuable, no matter whether it is "boring" proteomics, or more exciting glycoproteomics, cross-linking mass spectrometry etc.
A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics
Accurate and comprehensive peptide spectrum annotation is a crucial step to interpreting mass spectrometry-based proteomics data. While peak assignment in peptide fragmentation spectra is central to a...
pubs.acs.org
Interested in ultra low input phosphoproteomics? Here we summarised the current considerations and opportunities when working with rare populations of cells. Congrats to @emgaiz.bsky.social! #TeamMassSpec
Communications Biology@commsbio.nature.com · 8mo ago💡New review by @emgaiz.bsky.social & @silviasurinova.bsky.social summarises recent innovations driving low-input phosphoproteomics, focusing on miniaturised workflows, multiplexed labelling, automated enrichment, and acquisition methods for scarce biological material. www.nature.com/articles/s42...
#HUPO2025 interested in #topdownproteomics please come to join us in the Friends of HUPO reception 18:45-19:45 pm Westin Frontenac Ballroom Foyer 😀❄️ @nlkproteomics.bsky.social @proteoforms.bsky.social @jyates.bsky.social @hecklab.bsky.social #teammassspec
Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...
🔬 For more, delve into this paper published in Molecular & Cellular Proteomics ( @asbmbjournals.bsky.social): www.mcponline.org/article/S153.... Congratulations to @tkadava.bsky.social, @hecklab.bsky.social and colleagues on this fascinating work!
Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP
In BriefHere, we used an integrative approach to study key interactions of a spider-like complement inhibitor from human serum, C4b-binding protein (C4BP). We characterized interactions with complemen...
mcponline.org
American Society for Biochemistry and Molecular Biology@asbmb.bsky.social · 9mo ago#Halloween Trivia 🕸️ Did you know human blood contains spider-shaped proteins that help regulate the innate immune response? 🕷️Discover how C4BP uses its eight “legs” to catch proteins and control inflammation: www.asbmb.org/asbmb-.... #Immunology #MolCellProt #MassSpec
For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏 arxiv.org/abs/2508.096...
Thermal Tracks: A Gaussian process-based framework for universal melting curve analysis enabling unconstrained hit identification in thermal proteome profiling experiments
Thermal Tracks is a Python-based statistical framework for analyzing protein thermal stability data that overcomes key limitations of existing thermal proteome profiling (TPP) work-flows. Unlike stand...
arxiv.org
🧵(4/7) 🔬 We have put together a fascinating #Keynote #Speakers team: • Prof. Albert Heck - @hecklab.bsky.social • Dr. Hamish Stewart - @hamishs.bsky.social • Prof. Olga Vitek - @olgavitek.bsky.social l • Prof. Ron M.A. Heeren
My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc
Open Postdoctoral position, faculty mentor Ruth Huttenhain | Office of Postdoctoral Affairs
postdocs.stanford.edu
Having a great time at msandm2025.org with a great bunch of people interesting in visualizing biomolecules, together with my co-chairs @joostsnijder.bsky.social @vixklen.bsky.social & Kyle Fort. Learning so much from all posters & lectures. We thanks all participants for joining us in Utrecht.
We’re hosting the MS+M conference in Utrecht today, lots of great talks ahead at the intersection of mass spec and microscopy. Here’s @hecklab.bsky.social kicking things off.
Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry: Molecular Therapy Nucleic Acids www.cell.com/molecular-th.... Even visualizing > 10 million Da plasmids by the incredible Eduard Ebberink
Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry
Heck and colleagues developed a mass photometry-based method for accurate and fast mass determination of plasmid DNA. Conventional mass photometry methods are not applicable for large DNA particles; h...
cell.com
Preparations in full swing. Exciting program, looking forward to msandm2025.org and welcome our guests in Utrecht to discuss mass spectrometry, atomic force & electron microscopy and single molecule techniques
