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Laurence Ettwiller

@ettwiller.bsky.social

Scientist working at New England Biolabs. Tweets and comments represent my personal opinion and do not necessarily reflect the opinions of New England Biolabs.

45 Posts132 Follower80 Folgt
Gang Fang@gangfang.bsky.social · 3mo ago

Glad that our paper is out today in @cp-cellhostmicrobe.bsky.social A baby received a routine course of amoxicillin. In that infant's #gut 💩, we could see something remarkable, already present **before** the antibiotic arriveda single strain 🦠 of #Akkermansia muciniphila was already running 1/n

Epigenetic phase variation in the gut microbiome enhances bacterial adaptation

Ni et al. show that epigenetic phase variation (ePV)—gene expression changes mediated by bacterial DNA methylation—is prevalent in the human gut microbiome and associated with fluctuating environments...

cell.com

Laurence Ettwiller@ettwiller.bsky.social · 4mo ago

Really nice paper on Mu-encoded Mom enzyme that catalyzes 6-NcmdA by transferring glycine from charged tRNA-Gly to the N6 position of adenine . www.nature.com/articles/s41... Congrats to all authors !

A single viral enzyme drives tRNA-dependent hypermodification of DNA at adenine - Nature Communications

Phages install chemically complex DNA hypermodifications as anti-defense strategies. Here, the authors uncover transfer and rearrangement of glycine on dA driven by Mom, a tRNA-dependent DNA aminoacyl...

nature.com

Oliver Strimpel@geologybites.bsky.social · 11mo ago

🧪⚒️Just released an episode on the dynamics of subduction zones with Claudio Faccenna. Not only do trenches roll back and move laterally, they also advance and flip polarity. But when they penetrate the viscous lower mantle they get locked in place. Enjoy listening!

The figure shows sections of P-wave tomography anomalies along the yellow lines on the map (Fukao & Obayashi, 2013), seismicity (orange dots on profiles; Engdahl et al., 1998), plate velocities (orange vectors; Argus et al., 2011), and volcanoes (cyan inverted triangles; Siebert & Simkin, 2023). The Western Pacific and Japan subduction zones (the two most northerly zones) do not appear to penetrate the lower mantle, unlike those of Indonesia and Kermadec (north of New Zealand). Whether a slab penetrates the lower mantle depends on factors such as the duration of subduction and the angle at which the slab reaches the 660-km discontinuity, with steeper angles favoring descent. Becker, T and Faccenna, C. (2025), Tectonic Geodynamics, Princeton University PressSubduction zones along the west coast of the Americas. In the podcast, Faccenna described how the slab subducting below the Andes has entered the lower mantle where its lateral movement is restricted by the higher viscosity there. The subduction zones beneath northern South America and Central America show evidence of penetration into the lower mantle, reaching depths of 1,300 km or more. By contrast, the younger Caribbean subduction zone does not. Becker, T and Faccenna, C. (2025), Tectonic Geodynamics, Princeton University PressLeft: map showing seafloor ages in the western Pacific. The back-arc basins shown appear mainly as the red and orange regions, i.e., having the youngest ages of 0 and 30 million years. Center: more detailed seafloor age map of the Izu-Bonin-Marianas region. Right: P-wave tomography sections along the green lines labeled A, B, and C, revealing the varying shape of the subduction zone going from north to south. The western Pacific subduction zone is characterized by back-arc extension in the overriding plate that began within the last 30 million years (left panel). Tomography and seismicity data show that along the Izu–Bonin region (section B1–B2), a double subduction system is present, resulting from subduction of both the Pacific Plate (to the east) and the Philippine Plate (to the west). Becker, T and Faccenna, C. (2025), Tectonic Geodynamics, Princeton University PressThe Izu–Mariana subduction system is unique in that the trench is advancing toward the overriding plate (right panel). Bottom left: tomographic section along the red line on the map at right shows the two subducting slabs. Top left: numerical model of single subduction and double subduction. The double subduction simulation replicates quite a few features appearing on the tomographic section, such as the apparent flattening out of the subducting slabs between the depths of 400 and 600 km. In a single-slab system, the trench migrates backward, whereas in a double-slab system, the rear slab drives trench advance. The simulation also reproduces the tomographic section (bottom left, section along the red line on the map at right), which clearly shows the presence of two subducting slabs. Faccenna, C. et al. (2018), Tectonophysics, 746, 229
Stand Up For Science France@standupforscifr.bsky.social · last yr.

#StandUpForScience #Toulouse @sufs-paris-rp.bsky.social @emmanuelleperez.bsky.social "C'est très important d'avoir un lien très fort entre la recherche et la formation, de former à l'esprit scientifique pour se confronter à la complexité du monde d'aujourd'hui" www.francetvinfo.fr/replay-jt/fr...

Le 14h/16h du vendredi 7 mars 2025

Le 14h/16h du vendredi 7 mars 2025. JT franceinfo consultable en ligne en replay pour voir et revoir ce journal télé qui décrypte l'actualité.

francetvinfo.fr

Anna Kuchina@annabiosys.bsky.social · 2y ago

How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.biorxiv.org/content/10.1...

Combinatorial phenotypic landscape enables bacterial resistance to phage infection

Success of phage therapies is limited by bacterial defenses against phages. While a large variety of anti-phage defense mechanisms has been characterized, how expression of these systems is distribute...

biorxiv.org

Zeynep Baharoglu@zeynepbaharoglu.bsky.social · 2y ago

Our paper on 🦠queuosine 34 modification of tRNA tyrosine and antibiotic response is finally out in its final form in @eLife ... and quite different from the preprint version. Many thanks to reviewers, editors and kudos to all authors🙏 elifesciences.org/articles/96317

Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

tRNA Q34 modification impacts tyrosine codon decoding and leads to proteome reprogramming in response to antibiotic stress in Vibrio cholerae.

elifesciences.org